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N-Butanoyl-L-homoserine lactone

🥰Excellent
Catalog No. T18408Cas No. 67605-85-0
Alias N-Butyryl-L-homoserine lactone, C4-HSL

N-Butanoyl-L-homoserine lactone (C4-HSL) is a cleavable ADC linker used in the synthesis of antibody-drug conjugates (ADCs). It exhibits antibacterial activity and is employed in antibacterial biofilm[1].

N-Butanoyl-L-homoserine lactone
Other Forms of N-Butanoyl-L-homoserine lactone:
N-Butanoyl-DL-homoserine lactoneT1378898426-48-3
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N-Butanoyl-L-homoserine lactone

🥰Excellent
Purity: 99.43%
Catalog No. T18408Alias N-Butyryl-L-homoserine lactone, C4-HSLCas No. 67605-85-0
N-Butanoyl-L-homoserine lactone (C4-HSL) is a cleavable ADC linker used in the synthesis of antibody-drug conjugates (ADCs). It exhibits antibacterial activity and is employed in antibacterial biofilm[1].
Pack SizePriceAvailabilityQuantity
25 mg$29In Stock
50 mgPreferentialIn Stock
1 mL x 10 mM (in DMSO)$39In Stock
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Batch Information

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Purity:99.43%
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COA HPLC HNMR

Product Introduction

Bioactivity
Description
N-Butanoyl-L-homoserine lactone (C4-HSL) is a cleavable ADC linker used in the synthesis of antibody-drug conjugates (ADCs). It exhibits antibacterial activity and is employed in antibacterial biofilm[1].
In vitro
ADCs are comprised of an antibody to which is attached an ADC cytotoxin through an ADC linker.
SynonymsN-Butyryl-L-homoserine lactone, C4-HSL
Chemical Properties
Molecular Weight171.19
FormulaC8H13NO3
Cas No.67605-85-0
SmilesCCCC(=O)N[C@H]1CCOC1=O
Relative Density.1.13
Storage & Solubility Information
StoragePowder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.
Solubility Information
DMSO: 30 mg/mL (175.24 mM), Sonication is recommended.
H2O: 30 mg/mL (175.24 mM), Sonication is recommended.
Solution Preparation Table
DMSO/H2O
1mg5mg10mg50mg
1 mM5.8415 mL29.2073 mL58.4146 mL292.0731 mL
5 mM1.1683 mL5.8415 mL11.6829 mL58.4146 mL
10 mM0.5841 mL2.9207 mL5.8415 mL29.2073 mL
20 mM0.2921 mL1.4604 mL2.9207 mL14.6037 mL
50 mM0.1168 mL0.5841 mL1.1683 mL5.8415 mL
100 mM0.0584 mL0.2921 mL0.5841 mL2.9207 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:
TargetMol | Animal experimentsFor example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . TargetMol | Animal experiments A total of 10 animals were administered, and the formula you used is 5% TargetMol | reagent DMSO+30% PEG300+5% Tween 80+60% Saline/PBS/ddH2O. So your working solution concentration is 2 mg/mL。
Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSOTargetMol | reagent (mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.
Preparation method for in vivo formula: Take 50 μL DMSOTargetMol | reagent main solution, add 300 μLPEG300TargetMol | reagent mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLSaline/PBS/ddH2OTargetMol | reagent mix well and clarify
For Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.
All types of co-solvents required for the protocol, such asDMSO, PEG300/ PEG400, Tween 80, SBE-β-CD, corn oil are available for purchase on the TargetMol website with a simple click.
1 Enter information below:
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2 Enter the in vivo formulation:
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Keywords

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