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1-Naphthohydroxamic acid

Name: 1-Naphthohydroxamic acid
Brand: TargetMol
SKU: T13996
Price: 29 USD
Availability: InStock
Rating: 5 (10 reviews)

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Catalog No. T13996Cas No. 6953-61-3

1-Naphthohydroxamic acid (Compound 2) is a potent and selective HDAC8 inhibitor with an IC50 of 14 μM, demonstrating greater selectivity for HDAC8 than class I HDAC1 and class II HDAC6 (IC50 >100 μM). It does not increase global histone H4 acetylation or reduce total intracellular HDAC activity but can induce tubulin acetylation[1][2].

1-Naphthohydroxamic acid

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Purity: 99.19%

Catalog No. T13996Cas No. 6953-61-3

Pack Size	Price	USA Warehouse	Global Warehouse
5 mg	$29	In Stock	In Stock
10 mg	$58	In Stock	In Stock
25 mg	$116	In Stock	In Stock
50 mg	$223	In Stock	In Stock
100 mg	$333	In Stock	In Stock
200 mg	$478	In Stock	In Stock
1 mL x 10 mM (in DMSO)	$34	In Stock	In Stock

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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]

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Batch Information

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Purity:99.19%

Appearance:Solid

Color:White

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COA HNMR LCMS

Product Introduction

Bioactivity

Description	1-Naphthohydroxamic acid (Compound 2) is a potent and selective HDAC8 inhibitor with an IC50 of 14 μM, demonstrating greater selectivity for HDAC8 than class I HDAC1 and class II HDAC6 (IC50 >100 μM). It does not increase global histone H4 acetylation or reduce total intracellular HDAC activity but can induce tubulin acetylation[1][2].
Targets&IC50	HDAC8:14 μM, HDAC1:>100 μM, HDAC6:>100 μM
In vitro	1-Naphthohydroxamic acid (compound 2; 20-40 μM; 0-144 hours; BE(2)-C, SK-N-BE(2), and SH-SY5Y cells) reduces cell numbers in a concentration-dependent manner [2]. It decreases clone formation in soft agar in a similar manner [2]. In HeLa and HEK293 cells treated with 1-Naphthohydroxamic acid (compound 2; 0.8 μM, 4 μM, 20 μM, or 100 μM), only tubulin becomes hyperacetylated [1]. At concentrations within its in vitro IC50 against HDAC8, 1-Naphthohydroxamic acid (compound 2) reduces cell density and induces outgrowth of neurofilament-positive neurite-like structures.
In vivo	1-Naphthohydroxamic acid has the maximum tolerable doses at 50?mg/kg per day. At these concentrations, neither body weight nor blood parameters are critically changed[3]. Dose-limiting toxicities (DLTs) of 1-Naphthohydroxamic acid (compound 2; 0-40 mg/kg; intraperitoneal injection; daily; for 10 day; NMRI Foxn1 nude mice) include weight loss and signs of liver toxicity, as evidenced by elevated plasma liver enzymes and detection of necrotic areas on histological liver examination. Pharmacokinetic studies after intraperitoneal administration of the inhibitors identified the half-life of 1-Naphthohydroxamic acid to be ~15?min, with a plasma peak concentration of ~30?μM[3].

Chemical Properties

Molecular Weight	187.19
Formula	C₁₁H₉NO₂
Cas No.	6953-61-3
Smiles	ONC(=O)c1cccc2ccccc12
Relative Density.	1.291g/cm3

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 125 mg/mL (667.77 mM), Sonication is recommended.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	5.3422 mL	26.7108 mL	53.4217 mL	267.1083 mL
5 mM	1.0684 mL	5.3422 mL	10.6843 mL	53.4217 mL
10 mM	0.5342 mL	2.6711 mL	5.3422 mL	26.7108 mL
20 mM	0.2671 mL	1.3355 mL	2.6711 mL	13.3554 mL
50 mM	0.1068 mL	0.5342 mL	1.0684 mL	5.3422 mL
100 mM	0.0534 mL	0.2671 mL	0.5342 mL	2.6711 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:

For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, TargetMol | Animal experiments

and a total of 10 animals are to be administered, using a formulation of TargetMol | reagent

10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH₂O , the resulting working solution concentration would be 2 mg/mL.

Stock Solution Preparation:

Dissolve 2 mg of the compound in 100 μL DMSO TargetMol | reagent to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.

Preparation of the In Vivo Formulation:

1) Add 100 μL of the DMSO TargetMol | reagent stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.

2) Add 50 μL Tween 80 and mix well until fully clarified.

3) Add 450 μL Saline,PBS or ddH₂O TargetMol | reagent and mix thoroughly until a homogeneous solution is obtained.

This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.

All co-solvents required for this protocol, includingDMSO, PEG300/PEG400, Tween 80, SBE-β-CD, and Corn oil, are available for purchase on the TargetMol website.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc