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LeuRS-IN-1
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Catalog No. T38775Cas No. 1364914-72-6
LeuRS-IN-1 is an orally active and potent Mycobacterium tuberculosis leucyl-tRNA synthetase inhibitor with anti-leukemic and anti-malarial activity, inhibits M.tb LeuRS, inhibits HepG2 protein synthesis, and can be used in leukemia research.
LeuRS-IN-1
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Catalog No. T38775Cas No. 1364914-72-6
LeuRS-IN-1 is an orally active and potent Mycobacterium tuberculosis leucyl-tRNA synthetase inhibitor with anti-leukemic and anti-malarial activity, inhibits M.tb LeuRS, inhibits HepG2 protein synthesis, and can be used in leukemia research.
| Pack Size | Price | USA Warehouse | Global Warehouse | Quantity |
|---|---|---|---|---|
| 5 mg | $1,370 | 1-2 weeks | 1-2 weeks |
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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]
This molecule is a custom-made product. TargetMol has an excellent synthesis team with the experience and capability to provide you with cost-effective products.However, due to objective factors, there is a small probability that the synthesis may not be successful during the R&D process. We appreciate your understanding.If you have any questions, please feel free to contact us. We are committed to serving you wholeheartedly.
All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.
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Product Introduction
Bioactivity
Chemical Properties
Storage & Solubility Information
| Description | LeuRS-IN-1 is an orally active and potent Mycobacterium tuberculosis leucyl-tRNA synthetase inhibitor with anti-leukemic and anti-malarial activity, inhibits M.tb LeuRS, inhibits HepG2 protein synthesis, and can be used in leukemia research. |
| Targets&IC50 | HepG2 cells:65.8 μM (toxicity EC50), HepG2 protein synthesis:38.8 μM, HepG2 protein synthesis:19.6 μM (EC50), LeuRS (Mtb):0.06 μM, LeuRS (Mtb):0.075 μM (Kd) |
| In vitro | LeuRS-IN-1 showed high inhibitory activity against leucyl tRNA synthetase of Mycobacterium tuberculosis (M.tb) with IC50 and Kd values of 0.06 μM and 0.075 μM, respectively, and a MIC of 0.02 μg/mL against M.tb H37Rv strain. [1] LeuRS-IN-1 was less effective in inhibiting human cytoplasmic LeuRS and HepG2 protein synthesis, with IC50 and EC50 values of 38.8 μM and 19.6 μM, respectively, and the toxicity EC50 of LeuRS-IN-1 in HepG2 cells was 65.8 μM (48 h). [2] |
| In vivo | In animal experiments, LeuRS-IN-1 administered orally at 100 mg/kg per day for 14 consecutive days reduced the lung colony units of acute tuberculosis mice, while 33 mg/kg administered orally 5 days per week for 4 consecutive weeks reduced the lung and spleen colony units of chronic tuberculosis mice. [1] |
| Molecular Weight | 241.48 |
| Formula | C10H13BClNO3 |
| Cas No. | 1364914-72-6 |
| Smiles | O(CC)C1=C2C([C@@H](CN)OB2O)=C(Cl)C=C1 |
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature. |
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In Vivo Formulation Calculator (Clear solution)
Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:
For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, and a total of 10 animals are to be administered, using a formulation of 
10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH2O , the resulting working solution concentration would be 2 mg/mL.Stock Solution Preparation:
Dissolve 2 mg of the compound in 100 μL DMSO to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.
Preparation of the In Vivo Formulation:
1) Add 100 μL of the DMSO stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.
2) Add 50 μL Tween 80 and mix well until fully clarified.
3) Add 450 μL Saline,PBS or ddH2O and mix thoroughly until a homogeneous solution is obtained.
This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.
Dose Conversion
You can also refer to dose conversion for different animals. More Dose Conversion
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Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc
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