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Lp-PLA2/PLA2G7 Protein, Human, Recombinant (aa 22-441, His)

Catalog No. TMPJ-00553
Synonyms: PAF Acetylhydrolase, LDL-Associated Phospholipase A2, LDL-PLA(2), gVIIA-PLA2, 1-Alkyl-2-Acetylglycerophosphocholine Esterase, Platelet-Activating Factor Acetylhydrolase, Group-VIIA Phospholipase A2, PAF 2-Ac, 2-Acetyl-1-Alkylglycerophosphocholine Esterase

Platelet-Activating Factor Acetylhydrolase (PAFAH) is a secreted enzyme which belongs to the AB hydrolase superfamily and Lipase family and catalyzes the degradation of platelet-activating factor to biologically inactive products. PAFAH is produced by inflammatory cells and hydrolyzes oxidised phospholipids in LDL. PAFAH has been implicated in the development of atherosclerosis and has also been identified as a marker for cardiac disease. PAFAH might have a major physiologic effect in the presence of inflammatory bodily responses. PAFAH alters the action of PAF by hydrolyzing the sn-2 ester bond to yield the biologically inactive lyso-PAF. PAFAH has specificity for substrates with a short residue at the sn-2 position.

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Lp-PLA2/PLA2G7 Protein, Human, Recombinant (aa 22-441, His)
Pack Size Availability Price/USD Quantity
10 μg 5 days $ 184.00
50 μg 5 days $ 545.00
500 μg 5 days $ 1,900.00
1 mg 5 days $ 2,730.00
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Biological Description
Technical Params
Product Properties
Description Platelet-Activating Factor Acetylhydrolase (PAFAH) is a secreted enzyme which belongs to the AB hydrolase superfamily and Lipase family and catalyzes the degradation of platelet-activating factor to biologically inactive products. PAFAH is produced by inflammatory cells and hydrolyzes oxidised phospholipids in LDL. PAFAH has been implicated in the development of atherosclerosis and has also been identified as a marker for cardiac disease. PAFAH might have a major physiologic effect in the presence of inflammatory bodily responses. PAFAH alters the action of PAF by hydrolyzing the sn-2 ester bond to yield the biologically inactive lyso-PAF. PAFAH has specificity for substrates with a short residue at the sn-2 position.
Species Human
Expression System Human Cells
Tag C-6His
Accession Number AAH38452.1
Synonyms PAF Acetylhydrolase, LDL-Associated Phospholipase A2, LDL-PLA(2), gVIIA-PLA2, 1-Alkyl-2-Acetylglycerophosphocholine Esterase, Platelet-Activating Factor Acetylhydrolase, Group-VIIA Phospholipase A2, PAF 2-Ac, 2-Acetyl-1-Alkylglycerophosphocholine Esterase
Amino Acid Phe22-Asn441
Construction Recombinant Human Platelet-Activating Factor Acetylhydrolase is produced by our Mammalian expression system and the target gene encoding Phe22-Asn441 is expressed with a 6His tag at the C-terminus.
Protein Purity Greater than 90% as determined by reducing SDS-PAGE. (QC verified)
Molecular Weight 50-65 KDa, reducing conditions
Endotoxin Less than 0.1 ng/µg (1 EU/µg) as determined by LAL test.
Formulation Supplied as a 0.2 μm filtered solution of 50mM NaAc, 150mM NaCl, 50% Glycerol, pH5.0.
Stability & Storage

Store at ≤-70°C, stable for 6 months after receipt. Store at ≤-70°C, stable for 3 months under sterile conditions after opening. Please minimize freeze-thaw cycles.

Shipping

The product is shipped on dry ice/polar packs. Upon receipt, store it immediately at the temperature listed below.

Research Background Platelet-Activating Factor Acetylhydrolase (PAFAH) is a secreted enzyme which belongs to the AB hydrolase superfamily and Lipase family and catalyzes the degradation of platelet-activating factor to biologically inactive products. PAFAH is produced by inflammatory cells and hydrolyzes oxidised phospholipids in LDL. PAFAH has been implicated in the development of atherosclerosis and has also been identified as a marker for cardiac disease. PAFAH might have a major physiologic effect in the presence of inflammatory bodily responses. PAFAH alters the action of PAF by hydrolyzing the sn-2 ester bond to yield the biologically inactive lyso-PAF. PAFAH has specificity for substrates with a short residue at the sn-2 position.

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Keywords

Lp-PLA2/PLA2G7 Protein, Human, Recombinant (aa 22-441, His) PAF Acetylhydrolase LDL-Associated Phospholipase A2 LDL-PLA(2) gVIIA-PLA2 1-Alkyl-2-Acetylglycerophosphocholine Esterase Platelet-Activating Factor Acetylhydrolase Group-VIIA Phospholipase A2 PAF 2-Ac 2-Acetyl-1-Alkylglycerophosphocholine Esterase recombinant recombinant-proteins proteins protein

 

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