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3,5-Dimethoxystilbene

Name: 3,5-Dimethoxystilbene
Brand: TargetMol
SKU: TN7115
Price: 35 USD
Availability: InStock
Rating: 5 (10 reviews)

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Catalog No. TN7115Cas No. 21956-56-9

Alias cis-Pinosylvin dimethyl ether

3,5-Dimethoxystilbene (cis-Pinosylvin dimethyl ether) is a natural product isolated from the bark of jack pine (Pinus bunksiuna).

3,5-Dimethoxystilbene

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Purity: 98.39%

Catalog No. TN7115Alias cis-Pinosylvin dimethyl etherCas No. 21956-56-9

3,5-Dimethoxystilbene (cis-Pinosylvin dimethyl ether) is a natural product isolated from the bark of jack pine (Pinus bunksiuna).

Pack Size	Price	USA Warehouse	Global Warehouse
25 mg	$31	-	In Stock
50 mg	Preferential	-	In Stock
1 mL x 10 mM (in DMSO)	$35	-	In Stock

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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]

All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.

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Batch Information

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Purity:98.39%

Appearance:Solid

Color:White

Resource Download

COA HNMR LCMS

Product Introduction

3,5-Dimethoxystilbene AI Summary

3,5-Dimethoxystilbene exhibits a diverse range of bioactivities across various biological assays and targets. It inhibits the production of PGE-2 in LPS-stimulated RAW264.7 cells with an IC50 value of 100.0 nM and has larvicidal activity against Aedes aegypti larvae at a minimum concentration of 3.0 ppm, achieving complete larval mortality within 24 hours. The compound shows antimicrobial activity, though it is not highly effective against certain bacteria strains such as Mycobacterium smegmatis, Escherichia coli, Bacillus cereus, methicillin-resistant Staphylococcus aureus, and Staphylococcus aureus, with MIC values greater than 512.0 ug/mL. 3,5-Dimethoxystilbene also displays potency in several biochemical assays, including inhibition of JMJD2A-Tudor Domain, Nrf2 activation, HP1-beta Chromodomain interactions, polymerase iota, and mammalian selenoprotein thioredoxin reductase 1 (TrxR1). It inhibits Marburg Virus binding or entry into cells and induces DNA re-replication in MCF 10a breast cells and SW480 colon adenocarcinoma cells. Additionally, it modulates PINK1 expression, inhibits the SWI/SNF chromatin remodeling complex, and acts as an agonist of the gsp mutation responsible for Fibrous Dysplasia/McCune-Albright Syndrome. The compound inhibits Electrophorus electricus C2888 AChE with an IC50 value of 9,000.0 nM and exhibits dual activity at human and rat TRPA1 receptors. It acts as an antagonist at human TRPV1 receptors (IC50 > 10,000.0 nM) and also performs as both an agonist (EC50 of 1,700.0 nM, efficacy of 84.1%) and antagonist (IC50 of 3,400.0 nM) at rat TRPA1 receptors. Furthermore, it shows inhibition of TRPA1 activity at 30 µM, preincubated for 6 minutes, resulting in decreased AITC-induced calcium influx, while also inducing calcium influx under similar conditions. Characterized by a log P value of 4.15, 3,5-Dimethoxystilbene has high lipophilicity, which could influence its bioavailability, distribution, and interaction with biological systems..

Note: Summary generated by AI. Data source: ChEMBL

Bioactivity

Description	3,5-Dimethoxystilbene (cis-Pinosylvin dimethyl ether) is a natural product isolated from the bark of jack pine (Pinus bunksiuna).
Synonyms	cis-Pinosylvin dimethyl ether

Chemical Properties

Molecular Weight	240.3
Formula	C₁₆H₁₆O₂
Cas No.	21956-56-9
Smiles	COc1cc(OC)cc(\C=C\c2ccccc2)c1
Relative Density.	1.1228 g/cm3 (Estimated)

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 50 mg/mL (208.07 mM), Sonication is recommended.

In Vivo Formulation

10% DMSO+90% Corn Oil: 2.5 mg/mL (10.4 mM), Sonication is recommended.

Please add the solvents sequentially, clarifying the solution as much as possible before adding the next one. Dissolve by heating and/or sonication if necessary. Working solution is recommended to be prepared and used immediately. The formulation provided above is for reference purposes only. In vivo formulations may vary and should be modified based on specific experimental conditions.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	4.1615 mL	20.8073 mL	41.6146 mL	208.0732 mL
5 mM	0.8323 mL	4.1615 mL	8.3229 mL	41.6146 mL
10 mM	0.4161 mL	2.0807 mL	4.1615 mL	20.8073 mL
20 mM	0.2081 mL	1.0404 mL	2.0807 mL	10.4037 mL
50 mM	0.0832 mL	0.4161 mL	0.8323 mL	4.1615 mL
100 mM	0.0416 mL	0.2081 mL	0.4161 mL	2.0807 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:

For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, TargetMol | Animal experiments

and a total of 10 animals are to be administered, using a formulation of TargetMol | reagent

10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH₂O , the resulting working solution concentration would be 2 mg/mL.

Stock Solution Preparation:

Dissolve 2 mg of the compound in 100 μL DMSO TargetMol | reagent to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.

Preparation of the In Vivo Formulation:

1) Add 100 μL of the DMSO TargetMol | reagent stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.

2) Add 50 μL Tween 80 and mix well until fully clarified.

3) Add 450 μL Saline,PBS or ddH₂O TargetMol | reagent and mix thoroughly until a homogeneous solution is obtained.

This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.

All co-solvents required for this protocol, includingDMSO, PEG300/PEG400, Tween 80, SBE-β-CD, and Corn oil, are available for purchase on the TargetMol website.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc