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Zileuton sodium

Name: Zileuton sodium
Brand: TargetMol
SKU: T21836
Price: 98 USD
Availability: InStock
Rating: 5 (10 reviews)

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Catalog No. T21836Cas No. 118569-21-4

Alias Abbott 64077 sodium, A 64077 sodium

Zileuton sodium is a selective and reversible 5-lipoxygenase (5-LOX) inhibitor that suppresses LTB4 synthesis. It significantly reduces arachidonic acid-induced ear edema in mice (ED50 = 31 mg/kg) and is suitable for inflammation research.

Zileuton sodium

😃Good

Catalog No. T21836Alias Abbott 64077 sodium, A 64077 sodiumCas No. 118569-21-4

Pack Size	Price	USA Warehouse	Global Warehouse	Quantity
5 mg	$98	-	In Stock
10 mg	$155	-	In Stock

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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]

All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.

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Appearance:Solid

Color:Yellow

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COA

Product Introduction

Bioactivity

Description	Zileuton sodium is a selective and reversible 5-lipoxygenase (5-LOX) inhibitor that suppresses LTB4 synthesis. It significantly reduces arachidonic acid-induced ear edema in mice (ED50 = 31 mg/kg) and is suitable for inflammation research.
In vitro	Zileuton sodium inhibits 5-hydroxydocosahexaenoic acid synthesis in rat basophilic leukemia cell 20,000 x g supernatant and rat polymorphonuclear leukocytes (PMNL), with IC50 = 0.5/0.3 mM. It inhibits leukotriene (LT) B4 synthesis in rat PMNL (IC50 = 0.4 μM), human PMNL (IC50 = 0.4 μM), and human whole blood (IC50 = 0.9 μM). Inhibition of human PMNL LTB4 biosynthesis is readily reversed by simple washing procedures [1].
In vivo	Zileuton sodium (1200 mg/kg) inhibited polyp formation in the colon and small intestine of APCΔ468 rats. Zileuton sodium treatment suppressed proliferation rates of non-epithelial cells within polyps and increased apoptosis within polyps, contributing to reduced polyp incidence in the small intestine and colon of Zileuton sodium-fed APCΔ468 mice [4].
Synonyms	Abbott 64077 sodium, A 64077 sodium

Chemical Properties

Molecular Weight	258.27
Formula	C₁₁H₁₁N₂NaO₂S
Cas No.	118569-21-4
Smiles	O=C(N(C(C)C1=CC2=C(C=CC=C2)S1)[O-])N.[Na+]
Relative Density.	no data available

Storage & Solubility Information

Storage

keep away from moisture | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 80 mg/mL (309.75 mM), Sonication is recommended.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	3.8719 mL	19.3596 mL	38.7192 mL	193.5958 mL
5 mM	0.7744 mL	3.8719 mL	7.7438 mL	38.7192 mL
10 mM	0.3872 mL	1.9360 mL	3.8719 mL	19.3596 mL
20 mM	0.1936 mL	0.9680 mL	1.9360 mL	9.6798 mL
50 mM	0.0774 mL	0.3872 mL	0.7744 mL	3.8719 mL
100 mM	0.0387 mL	0.1936 mL	0.3872 mL	1.9360 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:

For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, TargetMol | Animal experiments

and a total of 10 animals are to be administered, using a formulation of TargetMol | reagent

10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH₂O , the resulting working solution concentration would be 2 mg/mL.

Stock Solution Preparation:

Dissolve 2 mg of the compound in 100 μL DMSO TargetMol | reagent to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.

Preparation of the In Vivo Formulation:

1) Add 100 μL of the DMSO TargetMol | reagent stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.

2) Add 50 μL Tween 80 and mix well until fully clarified.

3) Add 450 μL Saline,PBS or ddH₂O TargetMol | reagent and mix thoroughly until a homogeneous solution is obtained.

This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.

All co-solvents required for this protocol, includingDMSO, PEG300/PEG400, Tween 80, SBE-β-CD, and Corn oil, are available for purchase on the TargetMol website.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc