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FEN1-IN-4

🥰Excellent
Catalog No. T8545Cas No. 1995893-58-7
Alias FEN1 Inhibitor C2

FEN1-IN-4 (FEN1 Inhibitor C2) is an inhibitor of human flap endonuclease-1 (hFEN1)

FEN1-IN-4

FEN1-IN-4

🥰Excellent
Purity: 98.24%
Catalog No. T8545Alias FEN1 Inhibitor C2Cas No. 1995893-58-7
FEN1-IN-4 (FEN1 Inhibitor C2) is an inhibitor of human flap endonuclease-1 (hFEN1)
Pack SizePriceUSA WarehouseGlobal WarehouseQuantity
1 mg$40In StockIn Stock
2 mg$57In StockIn Stock
5 mg$89In StockIn Stock
10 mg$143In StockIn Stock
25 mg$253In StockIn Stock
50 mg$397In StockIn Stock
100 mg$613In StockIn Stock
1 mL x 10 mM (in DMSO)$98In StockIn Stock
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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]
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Purity:98.24%
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Product Introduction

Bioactivity
Description
FEN1-IN-4 (FEN1 Inhibitor C2) is an inhibitor of human flap endonuclease-1 (hFEN1)
In vitro
FEN1 Inhibitor C2 inhibition selectively impairs proliferation of colon cancer cells deficient in Cdc4 and Mre11a, both frequently mutated in colorectal cancers.?FEN1 has also emerged as a potential chemosensitizing target due to its role in LP-BER since it is critical for repair of MMS (methyl methanesulfonate)-induced alkylation damage, and its knockdown or inhibition increases sensitivity to TMZ (temozolomide) in glioblastoma and colorectal cancer cell lines.
SynonymsFEN1 Inhibitor C2
Chemical Properties
Molecular Weight232.24
FormulaC12H12N2O3
Cas No.1995893-58-7
SmilesOn1c(=O)n(CC2CC2)c2ccccc2c1=O
Relative Density.no data available
Storage & Solubility Information
StoragePowder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.
Solubility Information
DMSO: 100 mg/mL (430.59 mM), Sonication is recommended.
In Vivo Formulation
10% DMSO+40% PEG300+5% Tween 80+45% Saline: 4 mg/mL (17.22 mM), Sonication is recommended.
Please add the solvents sequentially, clarifying the solution as much as possible before adding the next one. Dissolve by heating and/or sonication if necessary. Working solution is recommended to be prepared and used immediately. The formulation provided above is for reference purposes only. In vivo formulations may vary and should be modified based on specific experimental conditions.
Solution Preparation Table
DMSO
1mg5mg10mg50mg
1 mM4.3059 mL21.5295 mL43.0589 mL215.2945 mL
5 mM0.8612 mL4.3059 mL8.6118 mL43.0589 mL
10 mM0.4306 mL2.1529 mL4.3059 mL21.5295 mL
20 mM0.2153 mL1.0765 mL2.1529 mL10.7647 mL
50 mM0.0861 mL0.4306 mL0.8612 mL4.3059 mL
100 mM0.0431 mL0.2153 mL0.4306 mL2.1529 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:
TargetMol | Animal experimentsFor example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . TargetMol | Animal experiments A total of 10 animals were administered, and the formula you used is 5% TargetMol | reagent DMSO+30% PEG300+5% Tween 80+60% Saline/PBS/ddH2O. So your working solution concentration is 2 mg/mL。
Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSOTargetMol | reagent (mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.
Preparation method for in vivo formula: Take 50 μL DMSOTargetMol | reagent main solution, add 300 μLPEG300TargetMol | reagent mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLSaline/PBS/ddH2OTargetMol | reagent mix well and clarify
For Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.
All types of co-solvents required for the protocol, such asDMSO, PEG300/ PEG400, Tween 80, SBE-β-CD, corn oil are available for purchase on the TargetMol website with a simple click.
1 Enter information below:
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2 Enter the in vivo formulation:
% DMSO
%
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Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc

Keywords

InhibitorinhibithumanhFEN1glioblastomaflapFEN1-IN-4FEN-1-IN-4FEN1IN4FEN1 IN 4endonucleasecolorectalcoloncellscancer
Related Tags: buy FEN1-IN-4 | purchase FEN1-IN-4 | FEN1-IN-4 cost | order FEN1-IN-4 | FEN1-IN-4 chemical structure | FEN1-IN-4 in vitro | FEN1-IN-4 formula | FEN1-IN-4 molecular weight
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