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FATP1-IN-1

Name: FATP1-IN-1
Brand: TargetMol
SKU: T38905
Price: 79 USD
Availability: InStock
Rating: 5 (10 reviews)

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Catalog No. T38905Cas No. 1431945-95-7

Alias FATP1-IN-1

FATP1-IN-1 is a potent inhibitor of fatty acid transport protein 1 (FATP1). It effectively inhibits the activity of recombinant human or mouse acyl-CoA synthetase, which is essential for the function of FATP1. The inhibition is characterized by IC50 values of 0.046 μM for human FATP1 and 0.60 μM for mouse FATP1.

FATP1-IN-1

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Purity: 99.83%

Catalog No. T38905Alias FATP1-IN-1Cas No. 1431945-95-7

Pack Size	Price	USA Warehouse	Global Warehouse
1 mg	$79	In Stock	In Stock
5 mg	$198	In Stock	In Stock
10 mg	$328	In Stock	In Stock
25 mg	$562	In Stock	In Stock
50 mg	$786	In Stock	In Stock
100 mg	$1,090	-	In Stock
1 mL x 10 mM (in DMSO)	$226	In Stock	In Stock

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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]

All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.

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Purity:99.83%

Appearance:Solid

Color:White

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COA LCMS HNMR

Product Introduction

Bioactivity

Description	FATP1-IN-1 is a potent inhibitor of fatty acid transport protein 1 (FATP1). It effectively inhibits the activity of recombinant human or mouse acyl-CoA synthetase, which is essential for the function of FATP1. The inhibition is characterized by IC50 values of 0.046 μM for human FATP1 and 0.60 μM for mouse FATP1.
In vivo	FATP1-IN-1 administered orally (p.o.) at a dosage of 10 mg/kg demonstrated pharmacokinetic parameters with a maximum concentration (C max) of 5.5 μg/mL, an area under the curve (AUC) of 36 μg h/mL, and a time to reach maximum concentration (T max) of 0.33 hours. These results were attained in a mouse plasma [1] model and surpassed the IC 50 value of 0.22 μM for mice, without accounting for plasma protein binding.
Synonyms	FATP1-IN-1

Chemical Properties

Molecular Weight	375.46
Formula	C₁₈H₂₂FN₅OS
Cas No.	1431945-95-7
Smiles	Fc1ccc(nc1)N1CCN(CC(=O)Nc2nc3CCCCc3s2)CC1
Relative Density.	1.349 g/cm3 (Predicted)

Storage & Solubility Information

Storage

In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 56.2 mg/mL (149.68 mM), Sonication is recommended.

In Vivo Formulation

10% DMSO+40% PEG300+5% Tween 80+45% Saline: 2 mg/mL (5.33 mM), Sonication is recommended.

Please add the solvents sequentially, clarifying the solution as much as possible before adding the next one. Dissolve by heating and/or sonication if necessary. Working solution is recommended to be prepared and used immediately. The formulation provided above is for reference purposes only. In vivo formulations may vary and should be modified based on specific experimental conditions.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	2.6634 mL	13.3170 mL	26.6340 mL	133.1700 mL
5 mM	0.5327 mL	2.6634 mL	5.3268 mL	26.6340 mL
10 mM	0.2663 mL	1.3317 mL	2.6634 mL	13.3170 mL
20 mM	0.1332 mL	0.6658 mL	1.3317 mL	6.6585 mL
50 mM	0.0533 mL	0.2663 mL	0.5327 mL	2.6634 mL
100 mM	0.0266 mL	0.1332 mL	0.2663 mL	1.3317 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:

For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, TargetMol | Animal experiments

and a total of 10 animals are to be administered, using a formulation of TargetMol | reagent

10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH₂O , the resulting working solution concentration would be 2 mg/mL.

Stock Solution Preparation:

Dissolve 2 mg of the compound in 100 μL DMSO TargetMol | reagent to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.

Preparation of the In Vivo Formulation:

1) Add 100 μL of the DMSO TargetMol | reagent stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.

2) Add 50 μL Tween 80 and mix well until fully clarified.

3) Add 450 μL Saline,PBS or ddH₂O TargetMol | reagent and mix thoroughly until a homogeneous solution is obtained.

This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.

All co-solvents required for this protocol, includingDMSO, PEG300/PEG400, Tween 80, SBE-β-CD, and Corn oil, are available for purchase on the TargetMol website.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc