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ADAMTS-5-IN-3

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Catalog No. T62282Cas No. 2688733-96-0

ADAMTS-5-IN-3 is a highly efficient inhibitor of ADAMTS-5 and ADAMTS-4, useful for studying diseases mediated by these enzymes.

ADAMTS-5-IN-3

ADAMTS-5-IN-3

😃Good
Catalog No. T62282Cas No. 2688733-96-0
ADAMTS-5-IN-3 is a highly efficient inhibitor of ADAMTS-5 and ADAMTS-4, useful for studying diseases mediated by these enzymes.
Pack SizePriceUSA WarehouseGlobal WarehouseQuantity
25 mg$2,2706-8 weeks6-8 weeks
50 mg$2,9806-8 weeks6-8 weeks
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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]
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Product Introduction

Bioactivity
Description
ADAMTS-5-IN-3 is a highly efficient inhibitor of ADAMTS-5 and ADAMTS-4, useful for studying diseases mediated by these enzymes.
Targets&IC50
ADAMTS-4:12 nM, ADAMTS-5:8 nM
In vitro
ADAMTS-5-IN-3 (compound 37-2) exhibited significant inhibition of ADAMTS-5 and ADAMTS-4 with IC50 values of 8 nM and 12 nM, respectively.[1]
Chemical Properties
Molecular Weight424.32
FormulaC20H23Cl2N3O3
Cas No.2688733-96-0
SmilesC(CC(=O)N1C[C@H](C)C=2C(CC1)=CC(Cl)=C(Cl)C2)[C@@]3(C(=O)NC(=O)N3)[C@H]4CC4
Storage & Solubility Information
Storagekeep away from direct sunlight,store at low temperature | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.
Solubility Information
DMSO: 160 mg/mL (377.07 mM), Sonication is recommended.
In Vivo Formulation
10% DMSO+40% PEG300+5% Tween 80+45% Saline: 5 mg/mL (11.78 mM), Sonication is recommended.
Please add the solvents sequentially, clarifying the solution as much as possible before adding the next one. Dissolve by heating and/or sonication if necessary. Working solution is recommended to be prepared and used immediately. The formulation provided above is for reference purposes only. In vivo formulations may vary and should be modified based on specific experimental conditions.
Solution Preparation Table
DMSO
1mg5mg10mg50mg
1 mM2.3567 mL11.7836 mL23.5671 mL117.8356 mL
5 mM0.4713 mL2.3567 mL4.7134 mL23.5671 mL
10 mM0.2357 mL1.1784 mL2.3567 mL11.7836 mL
20 mM0.1178 mL0.5892 mL1.1784 mL5.8918 mL
50 mM0.0471 mL0.2357 mL0.4713 mL2.3567 mL
100 mM0.0236 mL0.1178 mL0.2357 mL1.1784 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:
TargetMol | Animal experimentsFor example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . TargetMol | Animal experiments A total of 10 animals were administered, and the formula you used is 5% TargetMol | reagent DMSO+30% PEG300+5% Tween 80+60% Saline/PBS/ddH2O. So your working solution concentration is 2 mg/mL。
Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSOTargetMol | reagent (mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.
Preparation method for in vivo formula: Take 50 μL DMSOTargetMol | reagent main solution, add 300 μLPEG300TargetMol | reagent mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLSaline/PBS/ddH2OTargetMol | reagent mix well and clarify
For Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.
All types of co-solvents required for the protocol, such asDMSO, PEG300/ PEG400, Tween 80, SBE-β-CD, corn oil are available for purchase on the TargetMol website with a simple click.
1 Enter information below:
mg/kg
g
μL
2 Enter the in vivo formulation:
% DMSO
%
% Tween 80
% Saline/PBS/ddH2O

Dose Conversion

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Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc
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