Shopping Cart

Remove All
Your shopping cart is currently empty

Proceed to checkout Continue shopping

ADAMTS-5-IN-3

Name: ADAMTS-5-IN-3
Brand: TargetMol
SKU: T62282
Rating: 4.5 (1 reviews)

😃Good

Catalog No. T62282Cas No. 2688733-96-0

ADAMTS-5-IN-3 is a highly efficient inhibitor of ADAMTS-5 and ADAMTS-4, useful for studying diseases mediated by these enzymes.

ADAMTS-5-IN-3

😃Good

Catalog No. T62282Cas No. 2688733-96-0

ADAMTS-5-IN-3 is a highly efficient inhibitor of ADAMTS-5 and ADAMTS-4, useful for studying diseases mediated by these enzymes.

Pack Size	Price	Availability	Quantity
25 mg	$2,270	6-8 weeks
50 mg	$2,980	6-8 weeks

Add to Cart

Add to Quotation

Bulk & Custom

All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.

Questions

Batch Information

Select Batch

Resource Download

COA

Product Introduction

Bioactivity

Description	ADAMTS-5-IN-3 is a highly efficient inhibitor of ADAMTS-5 and ADAMTS-4, useful for studying diseases mediated by these enzymes.
Targets&IC50	ADAMTS-4:12 nM, ADAMTS-5:8 nM
In vitro	ADAMTS-5-IN-3 (compound 37-2) exhibited significant inhibition of ADAMTS-5 and ADAMTS-4 with IC50 values of 8 nM and 12 nM, respectively.[1]

Chemical Properties

Molecular Weight	424.32
Formula	C₂₀H₂₃Cl₂N₃O₃
Cas No.	2688733-96-0
Smiles	C(CC(=O)N1C[C@H](C)C=2C(CC1)=CC(Cl)=C(Cl)C2)[C@@]3(C(=O)NC(=O)N3)[C@H]4CC4

Storage & Solubility Information

Storage

keep away from direct sunlight,store at low temperature | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 160 mg/mL (377.07 mM), Sonication is recommended.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	2.3567 mL	11.7836 mL	23.5671 mL	117.8356 mL
5 mM	0.4713 mL	2.3567 mL	4.7134 mL	23.5671 mL
10 mM	0.2357 mL	1.1784 mL	2.3567 mL	11.7836 mL
20 mM	0.1178 mL	0.5892 mL	1.1784 mL	5.8918 mL
50 mM	0.0471 mL	0.2357 mL	0.4713 mL	2.3567 mL
100 mM	0.0236 mL	0.1178 mL	0.2357 mL	1.1784 mL

Calculator

Molarity Calculator
Dilution Calculator
Reconstitution Calculator
Molecular Weight Calculator

In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:

For example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . TargetMol | Animal experiments

A total of 10 animals were administered, and the formula you used is 5% TargetMol | reagent

DMSO+30% PEG300+5% Tween 80+60% Saline/PBS/ddH₂O. So your working solution concentration is 2 mg/mL。

Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO TargetMol | reagent

(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.

Preparation method for in vivo formula: Take 50 μL DMSO TargetMol | reagent

main solution, add 300 μLPEG300 TargetMol | reagent

mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLSaline/PBS/ddH₂O TargetMol | reagent

mix well and clarify

For Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.

All types of co-solvents required for the protocol, such asDMSO, PEG300/ PEG400, Tween 80, SBE-β-CD, corn oil are available for purchase on the TargetMol website with a simple click.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Sci Citations

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc