Shopping Cart
Remove All
Your shopping cart is currently empty
Ferroptosis inducer-11
Catalog No. T213129 Copy Product Info
🥰Excellent
Ferroptosisinducer-11 is an agent that induces ferroptosis, exhibiting significant cytotoxicity against HCT-116, NCM-60, and HT-29 cells with IC50 values of 0.43 μM, 3.14 μM, and 0.48 μM, respectively. It potently inhibits GPX4 enzyme activity with an IC50 of 1.86 μM. This compound induces ferroptosis and increases lipid ROS, malondialdehyde (MDA), and Fe2+ levels in colon cancer cells while reducing glutathione (GSH) levels. Ferroptosisinducer-11 is useful for colon cancer research.
Ferroptosis inducer-11
Copy Product Info🥰Excellent
Catalog No. T213129
Ferroptosisinducer-11 is an agent that induces ferroptosis, exhibiting significant cytotoxicity against HCT-116, NCM-60, and HT-29 cells with IC50 values of 0.43 μM, 3.14 μM, and 0.48 μM, respectively. It potently inhibits GPX4 enzyme activity with an IC50 of 1.86 μM. This compound induces ferroptosis and increases lipid ROS, malondialdehyde (MDA), and Fe2+ levels in colon cancer cells while reducing glutathione (GSH) levels. Ferroptosisinducer-11 is useful for colon cancer research.
Ferroptosis inducer-11
| Pack Size | Price | USA Stock | Global Stock | Quantity |
|---|---|---|---|---|
| 10 mg | Inquiry | Inquiry | Inquiry | |
| 50 mg | Inquiry | Inquiry | Inquiry |
For In stock only · Estimated delivery: USA Stock (1-2 days) Global Stock (5-7 days)
Add to Quotation
For research use only—not for human use. No sales to individuals. Use as intended only.
Resource Download
Product Introduction
Bioactivity
Chemical Properties
Storage & Solubility Information
| Description | Ferroptosisinducer-11 is an agent that induces ferroptosis, exhibiting significant cytotoxicity against HCT-116, NCM-60, and HT-29 cells with IC50 values of 0.43 μM, 3.14 μM, and 0.48 μM, respectively. It potently inhibits GPX4 enzyme activity with an IC50 of 1.86 μM. This compound induces ferroptosis and increases lipid ROS, malondialdehyde (MDA), and Fe2+ levels in colon cancer cells while reducing glutathione (GSH) levels. Ferroptosisinducer-11 is useful for colon cancer research. |
| Targets&IC50 | GPX4:1.86 μM |
| In vitro | Ferroptosis inducer-11 (Compound 30) demonstrates significant inhibitory activity on colony formation in HCT-116 colon cancer cells at concentrations of 0.25-1 μM over 24 hours. It exhibits potent cytotoxicity against HCT-116, NCM-60, and HT-29 cells, with IC 50 values of 0.43 μM, 3.14 μM, and 0.48 μM, respectively. In HCT-116 cells, Ferroptosis inducer-11 significantly increases lipid ROS levels in a time- and dose-dependent manner at 0.25-1 μM for 6-24 hours. It also elevates MDA levels, raises intracellular Fe 2+ levels, and decreases GSH levels in a dose-dependent manner at 0.25-1 μM over 12 hours. This compound strongly inhibits GPX4 with an IC 50 value of 1.86 μM and downregulates GPX4 protein expression in a time- and dose-dependent manner at 0.25-1 μM for 6-24 hours in HCT-116 cells. |
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year Shipping with blue ice/Shipping at ambient temperature. |
Citations
Calculator
In Vivo Formulation Calculator (Clear solution)
Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:
For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, and a total of 10 animals are to be administered, using a formulation of 
10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH2O , the resulting working solution concentration would be 2 mg/mL.Stock Solution Preparation:
Dissolve 2 mg of the compound in 100 μL DMSO to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.
Preparation of the In Vivo Formulation:
1) Add 100 μL of the DMSO stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.
2) Add 50 μL Tween 80 and mix well until fully clarified.
3) Add 450 μL Saline,PBS or ddH2O and mix thoroughly until a homogeneous solution is obtained.
This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.
Dose Conversion
You can also refer to dose conversion for different animals. More Dose Conversion
Tech Support
Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc
Preview
Related Tags: buy Ferroptosis inducer-11 | purchase Ferroptosis inducer-11 | Ferroptosis inducer-11 cost | order Ferroptosis inducer-11 | Ferroptosis inducer-11 in vitro
Generate Quote
Catalog No.: Cas No.:
Add
| Size | Quantity | Unit Price | Amount | Operation |
|---|
Generate Quote
- TOP
Feedback
Hello! How can I help you today? 
Copyright © 2015-2026 TargetMol Chemicals Inc. All Rights Reserved.