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Vincamine

Name: Vincamine
Brand: TargetMol
SKU: T1286
Price: 40 USD
Availability: InStock
Rating: 5 (10 reviews)

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Catalog No. T1286Cas No. 1617-90-9

Alias Perval, Oxybral, Novicet, Equipur, Devincan, Angiopac

Vincamine (Perval) is a major alkaloid of Vinca minor L., Apocynaceae. It has been used therapeutically as a vasodilator and antihypertensive agent, particularly in cerebrovascular disorders.

Vincamine

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Purity: 98.96%

Catalog No. T1286Alias Perval, Oxybral, Novicet, Equipur, Devincan, AngiopacCas No. 1617-90-9

Vincamine (Perval) is a major alkaloid of Vinca minor L., Apocynaceae. It has been used therapeutically as a vasodilator and antihypertensive agent, particularly in cerebrovascular disorders.

Pack Size	Price	USA Warehouse	Global Warehouse	Quantity
500 mg	$40	In Stock	In Stock
1 g	$56	In Stock	In Stock

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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]

All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.

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Purity:98.96%

Color:White

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COA HNMR HPLC LCMS

Product Introduction

Vincamine AI Summary

Vincamine exhibits a broad spectrum of biological activities. In hypoxia tests, it induced the first gasps in 0.04083 hours after intraperitoneal administration of 20 mg/kg. It demonstrates antimelanogenic activity by reducing intracellular melanin levels in mouse B16 cells, with an IC50 value of 68900.0 nM over 4 days, achieving less than 50% melanin reduction. The compound induces genotoxicity and inhibits ELG1-dependent DNA repair in human embryonic kidney cells at potencies of 16353.5 nM and 14575.0 nM, respectively. It acts as a delayed death inhibitor for the malarial parasite plastid with potencies of 11689.1 nM and 13115.4 nM and shows antagonistic activity towards receptors responsible for Fibrous Dysplasia/McCune-Albright Syndrome with a potency of 31622.8 nM. Additionally, it blocks Ebola virus entry with an AC50 of 8912.5 nM and exhibits high metabolic clearance in human liver microsomes at 66.0 mL·min-1·g-1. In enzyme inhibition assays, Vincamine inhibits electric eel AChE and horse BChE at 7.29% and 3.22%, respectively, at 2 mg/ml. It significantly inhibits fluorescent sodium uptake in OATP1B3 and OATP1B1 transfected cells by 88.88% and 72.87% at 10 µM. It has minimal impact on Vero E6 cell viability when infected with SARS-CoV-2 (inhibition index of 0.1041) but exhibits moderate antiviral activity with IC50 values above 20000.0 nM and 19952.62 nM. The compound also shows inhibitory effects on beta-arrestin 2 recruitment by multiple human receptors, and exhibits cytoprotective activity against STZ-induced apoptosis in rat INS-1 832/13 cells with 63.0% inhibition at 20 µM. Vincamine modulates various cellular targets, inhibiting human KCNH2 (AC50 = 460.0 nM) and displaying activity as both agonist and antagonist on human ADRA1A, CHRM1, TBXA2R, and HTR2B. For other targets like DRD1, SLC6A3, and others, it shows high binding without significant activity within the tested concentration range, maintaining AC50 values above 30000.0 nM. These multifaceted bioactivities highlight its potential for diverse pharmacological applications and necessitate further investigation to elucidate its full therapeutic potential..

Note: Summary generated by AI. Data source: ChEMBL

Bioactivity

Description	Vincamine (Perval) is a major alkaloid of Vinca minor L., Apocynaceae. It has been used therapeutically as a vasodilator and antihypertensive agent, particularly in cerebrovascular disorders.
Synonyms	Perval, Oxybral, Novicet, Equipur, Devincan, Angiopac

Chemical Properties

Molecular Weight	354.44
Formula	C₂₁H₂₆N₂O₃
Cas No.	1617-90-9
Smiles	CCC12CCCN3CCC4=C(C13)N(C1=CC=CC=C41)C(O)(C2)C(=O)OC
Relative Density.	1.1640 g/cm3 (Estimated)

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 1 mg/mL (2.82 mM), Sonication and heating are recommended.

In Vivo Formulation

10% DMSO+40% PEG300+5% Tween 80+45% Saline: 1 mg/mL (2.82 mM), Sonication is recommended.

Please add the solvents sequentially, clarifying the solution as much as possible before adding the next one. Dissolve by heating and/or sonication if necessary. Working solution is recommended to be prepared and used immediately. The formulation provided above is for reference purposes only. In vivo formulations may vary and should be modified based on specific experimental conditions.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	2.8214 mL	14.1068 mL	28.2135 mL	141.0676 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:

For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, TargetMol | Animal experiments

and a total of 10 animals are to be administered, using a formulation of TargetMol | reagent

10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH₂O , the resulting working solution concentration would be 2 mg/mL.

Stock Solution Preparation:

Dissolve 2 mg of the compound in 100 μL DMSO TargetMol | reagent to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.

Preparation of the In Vivo Formulation:

1) Add 100 μL of the DMSO TargetMol | reagent stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.

2) Add 50 μL Tween 80 and mix well until fully clarified.

3) Add 450 μL Saline,PBS or ddH₂O TargetMol | reagent and mix thoroughly until a homogeneous solution is obtained.

This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.

All co-solvents required for this protocol, includingDMSO, PEG300/PEG400, Tween 80, SBE-β-CD, and Corn oil, are available for purchase on the TargetMol website.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc