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ML 190
🥰Excellent
Catalog No. T22995Cas No. 1355244-02-8
Alias ML-190
ML 190 is a potent and selective κ opioid receptor (KOR) antagonist (Ki=129 nM), exhibiting an IC50=150 nM in β-arrestin assays, suitable for studying drug addiction.
ML 190
🥰Excellent
Purity: 99.88%
Catalog No. T22995Alias ML-190Cas No. 1355244-02-8
ML 190 is a potent and selective κ opioid receptor (KOR) antagonist (Ki=129 nM), exhibiting an IC50=150 nM in β-arrestin assays, suitable for studying drug addiction.
| Pack Size | Price | USA Warehouse | Global Warehouse | Quantity |
|---|---|---|---|---|
| 1 mg | $60 | - | In Stock | |
| 5 mg | $147 | - | In Stock | |
| 10 mg | $228 | - | In Stock | |
| 25 mg | $496 | - | In Stock | |
| 50 mg | $795 | - | In Stock | |
| 100 mg | $1,070 | - | In Stock | |
| 1 mL x 10 mM (in DMSO) | $158 | - | In Stock |
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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]
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Purity:99.88%
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Product Introduction
Bioactivity
Chemical Properties
| Description | ML 190 is a potent and selective κ opioid receptor (KOR) antagonist (Ki=129 nM), exhibiting an IC50=150 nM in β-arrestin assays, suitable for studying drug addiction. |
| Targets&IC50 | κ opioid receptor:120 nM, κ opioid receptor:129 nM (EC50) |
| In vitro | The plasma protein binding rate of ML 190 in Homo sapiens is 93.96% (1 μM) and 88.54% (10 μM), while in mice it is 88.46% (1 μM) and 80.07% (10 μM) respectively. The remaining plasma percentage after 3 hours is 100% in both Homo sapiens and mice. The remaining percentage after 1 hour in liver microsomes is 22.13% in Homo sapiens and 7.34% in mice. The hepatotoxicity LC50 is greater than 50 μM [1]. |
| Synonyms | ML-190 |
| Molecular Weight | 488.58 |
| Formula | C27H32N6O3 |
| Cas No. | 1355244-02-8 |
| Smiles | COc1ccc(cc1)N1CCN(CCCNC(=O)Cn2c3nccc(C)c3n3cccc3c2=O)CC1 |
| Relative Density. | 1.29 g/cm3 (Predicted) |
| Color | Yellow |
| Appearance | Solid |
Storage & Solubility Information
| Storage | store at low temperature | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature. | ||||||||||||||||||||
| Solubility Information | DMSO: 7.5 mg/mL (15.35 mM), Sonication and heating are recommended. | ||||||||||||||||||||
Solution Preparation Table | |||||||||||||||||||||
DMSO
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In Vivo Formulation Calculator (Clear solution)
Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:
For example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . A total of 10 animals were administered, and the formula you used is 5% 
DMSO+30% PEG300+5% Tween 80+60% Saline/PBS/ddH2O. So your working solution concentration is 2 mg/mL。Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO (mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.
(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.Preparation method for in vivo formula: Take 50 μL DMSO main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLSaline/PBS/ddH2O mix well and clarify
main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLSaline/PBS/ddH2O mix well and clarifyFor Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.
Dose Conversion
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Tech Support
Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc
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