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ML 190
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Catalog No. T22995Cas No. 1355244-02-8
Alias ML-190
ML 190 is a potent and selective κ opioid receptor (KOR) antagonist (Ki=129 nM), exhibiting an IC50=150 nM in β-arrestin assays, suitable for studying drug addiction.
ML 190
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Purity: 99.88%
Catalog No. T22995Alias ML-190Cas No. 1355244-02-8
ML 190 is a potent and selective κ opioid receptor (KOR) antagonist (Ki=129 nM), exhibiting an IC50=150 nM in β-arrestin assays, suitable for studying drug addiction.
| Pack Size | Price | USA Warehouse | Global Warehouse | Quantity |
|---|---|---|---|---|
| 1 mg | $60 | - | In Stock | |
| 5 mg | $147 | - | In Stock | |
| 10 mg | $228 | - | In Stock | |
| 25 mg | $496 | - | In Stock | |
| 50 mg | $795 | - | In Stock | |
| 100 mg | $1,070 | - | In Stock | |
| 1 mL x 10 mM (in DMSO) | $158 | - | In Stock |
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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]
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Purity:99.88%
Appearance:Solid
Color:Yellow
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Product Introduction
Bioactivity
Chemical Properties
Storage & Solubility Information
| Description | ML 190 is a potent and selective κ opioid receptor (KOR) antagonist (Ki=129 nM), exhibiting an IC50=150 nM in β-arrestin assays, suitable for studying drug addiction. |
| Targets&IC50 | κ opioid receptor:129 nM (EC50), κ opioid receptor:120 nM |
| In vitro | The plasma protein binding rate of ML 190 in Homo sapiens is 93.96% (1 μM) and 88.54% (10 μM), while in mice it is 88.46% (1 μM) and 80.07% (10 μM) respectively. The remaining plasma percentage after 3 hours is 100% in both Homo sapiens and mice. The remaining percentage after 1 hour in liver microsomes is 22.13% in Homo sapiens and 7.34% in mice. The hepatotoxicity LC50 is greater than 50 μM [1]. |
| Synonyms | ML-190 |
| Molecular Weight | 488.58 |
| Formula | C27H32N6O3 |
| Cas No. | 1355244-02-8 |
| Smiles | COc1ccc(cc1)N1CCN(CCCNC(=O)Cn2c3nccc(C)c3n3cccc3c2=O)CC1 |
| Relative Density. | 1.29 g/cm3 (Predicted) |
| Storage | store at low temperature | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature. | ||||||||||||||||||||
| Solubility Information | DMSO: 7.5 mg/mL (15.35 mM), Sonication and heating are recommended. | ||||||||||||||||||||
Solution Preparation Table | |||||||||||||||||||||
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In Vivo Formulation Calculator (Clear solution)
Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:
For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, and a total of 10 animals are to be administered, using a formulation of 
10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH2O , the resulting working solution concentration would be 2 mg/mL.Stock Solution Preparation:
Dissolve 2 mg of the compound in 100 μL DMSO to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.
Preparation of the In Vivo Formulation:
1) Add 100 μL of the DMSO stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.
2) Add 50 μL Tween 80 and mix well until fully clarified.
3) Add 450 μL Saline,PBS or ddH2O and mix thoroughly until a homogeneous solution is obtained.
This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.
Dose Conversion
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Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc
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