Shopping Cart

Remove All
Your shopping cart is currently empty

Oxyphenbutazone

Name: Oxyphenbutazone
Brand: TargetMol
SKU: T16419
Price: 45 USD
Availability: InStock
Rating: 5 (10 reviews)

🥰Excellent

Catalog No. T16419Cas No. 129-20-4

Oxyphenbutazone is an active metabolite of Phenylbutazone, an orally active COX inhibitor with antimicrobial and anti-inflammatory activity, selectively kills non-replicating Mycobacterium tuberculosis, and induces bone marrow failure.

Oxyphenbutazone

🥰Excellent

Purity: 99.88%

Catalog No. T16419Cas No. 129-20-4

Pack Size	Price	Availability
2 mg	$45	In Stock
5 mg	$72	In Stock
10 mg	$108	In Stock
25 mg	$183	In Stock
50 mg	$275	In Stock
100 mg	$413	In Stock
1 mL x 10 mM (in DMSO)	$119	In Stock

Add to Cart

Add to Quotation

Bulk & Custom

All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.

Questions

Batch Information

Select Batch

Purity:99.88%

Resource Download

COA HNMR LCMS

Product Introduction

Bioactivity

Description	Oxyphenbutazone is an active metabolite of Phenylbutazone, an orally active COX inhibitor with antimicrobial and anti-inflammatory activity, selectively kills non-replicating Mycobacterium tuberculosis, and induces bone marrow failure.
In vitro	Oxyphenbutazone enhances the anticancer effect of methotrexate (MTX) in Hep3B cells with hepatocyte repair. In Hep3B cells, 2.5-7.5 µM Oxyphenbutazone, treated for 48 hours, exhibited significant cytotoxicity when combined with MTX (0.25-1.0 µM). [1]
In vivo	In combination with MTX (5.0 or 2.5 mg/kg/week , intraperitoneal injection), Oxyphenbutazone (70 mg/kg/week, orally, in two divided doses, for 13 weeks of treatment) showed potential anticancer activity. [1]

Chemical Properties

Molecular Weight	324.37
Formula	C₁₉H₂₀N₂O₃
Cas No.	129-20-4
Smiles	O=C1N(C=2C=CC=CC2)N(C3=CC=C(O)C=C3)C(=O)C1CCCC
Relative Density.	1.241g/cm3

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 80 mg/mL (246.63 mM), Sonication is recommended.

In Vivo Formulation

10% DMSO+40% PEG300+5% Tween 80+45% Saline: 3.3 mg/mL (10.17 mM), Sonication is recommended.

Please add the solvents sequentially, clarifying the solution as much as possible before adding the next one. Dissolve by heating and/or sonication if necessary. Working solution is recommended to be prepared and used immediately. The formulation provided above is for reference purposes only. In vivo formulations may vary and should be modified based on specific experimental conditions.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	3.0829 mL	15.4145 mL	30.8290 mL	154.1450 mL
5 mM	0.6166 mL	3.0829 mL	6.1658 mL	30.8290 mL
10 mM	0.3083 mL	1.5414 mL	3.0829 mL	15.4145 mL
20 mM	0.1541 mL	0.7707 mL	1.5414 mL	7.7072 mL
50 mM	0.0617 mL	0.3083 mL	0.6166 mL	3.0829 mL
100 mM	0.0308 mL	0.1541 mL	0.3083 mL	1.5414 mL

Calculator

Molarity Calculator
Dilution Calculator
Reconstitution Calculator
Molecular Weight Calculator

In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:

For example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . TargetMol | Animal experiments

A total of 10 animals were administered, and the formula you used is 5% TargetMol | reagent

DMSO+30% PEG300+5% Tween 80+60% Saline/PBS/ddH₂O. So your working solution concentration is 2 mg/mL。

Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO TargetMol | reagent

(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.

Preparation method for in vivo formula: Take 50 μL DMSO TargetMol | reagent

main solution, add 300 μLPEG300 TargetMol | reagent

mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLSaline/PBS/ddH₂O TargetMol | reagent

mix well and clarify

For Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.

All types of co-solvents required for the protocol, such asDMSO, PEG300/ PEG400, Tween 80, SBE-β-CD, corn oil are available for purchase on the TargetMol website with a simple click.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Sci Citations

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc