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PB1

Name: PB1
Brand: TargetMol
SKU: T35888
Rating: 4.5 (1 reviews)

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Catalog No. T35888Cas No. 188714-28-5

PB1 is a highly-effective intracellular disulfide reducing agent with notable attributes such as excellent cell permeability, the capacity to generate a substantial intracellular concentration gradient, and remarkable stability. It serves as a borane-protected TCEP (tris(2-carboxyethyl)phosphine) analogue. PB1 demonstrates the potential to enhance the survival of retinal ganglion cells following axotomy in vitro at concentrations in the nanomolar and picomolar range. Consequently, PB1 has proven instrumental in the study of neuroprotective properties[1][2][3].

PB1

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Catalog No. T35888Cas No. 188714-28-5

Pack Size	Price	USA Warehouse	Global Warehouse
5 mg	$376	6-8 weeks	6-8 weeks
25 mg	$1,140	6-8 weeks	6-8 weeks
50 mg	$1,490	6-8 weeks	6-8 weeks
100 mg	$2,360	6-8 weeks	6-8 weeks
1 mL x 10 mM (in DMSO)	$345	6-8 weeks	6-8 weeks

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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]

All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.

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Product Introduction

Bioactivity

Description	PB1 is a highly-effective intracellular disulfide reducing agent with notable attributes such as excellent cell permeability, the capacity to generate a substantial intracellular concentration gradient, and remarkable stability. It serves as a borane-protected TCEP (tris(2-carboxyethyl)phosphine) analogue. PB1 demonstrates the potential to enhance the survival of retinal ganglion cells following axotomy in vitro at concentrations in the nanomolar and picomolar range. Consequently, PB1 has proven instrumental in the study of neuroprotective properties[1][2][3].
In vitro	PB1 significantly enhances the activation of the BDNF effector ERK1/2 and supports RGC survival [1].
In vivo	PB1 (150 μM; intraocular injection; 1 week) attenuates the loss of both retinal ganglion cells (RGC) soma and axons in experimental glaucoma[1]. PB1 single dose limits the biological activity in vivo. PB1 (0.001~100 μM; 72 hours) effectively rescues acutely axotomized retinal ganglion cells[1][2].

Chemical Properties

Molecular Weight	296.11
Formula	C₁₄H₂₂BO₄P
Cas No.	188714-28-5
Smiles	[P](CCC(OC)=O)(CCC(OC)=O)([B+3]([H-])([H-])[H-])C1=CC=CC=C1

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 100 mg/mL (337.71 mM), Sonication is recommended.

In Vivo Formulation

10% DMSO+40% PEG300+5% Tween-80+45% Saline: 3.3 mg/mL (11.14 mM), Sonication is recommended.

Please add the solvents sequentially, clarifying the solution as much as possible before adding the next one. Dissolve by heating and/or sonication if necessary. Working solution is recommended to be prepared and used immediately. The formulation provided above is for reference purposes only. In vivo formulations may vary and should be modified based on specific experimental conditions.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	3.3771 mL	16.8856 mL	33.7712 mL	168.8562 mL
5 mM	0.6754 mL	3.3771 mL	6.7542 mL	33.7712 mL
10 mM	0.3377 mL	1.6886 mL	3.3771 mL	16.8856 mL
20 mM	0.1689 mL	0.8443 mL	1.6886 mL	8.4428 mL
50 mM	0.0675 mL	0.3377 mL	0.6754 mL	3.3771 mL
100 mM	0.0338 mL	0.1689 mL	0.3377 mL	1.6886 mL

Calculator

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:

For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, TargetMol | Animal experiments

and a total of 10 animals are to be administered, using a formulation of TargetMol | reagent

10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH₂O , the resulting working solution concentration would be 2 mg/mL.

Stock Solution Preparation:

Dissolve 2 mg of the compound in 100 μL DMSO TargetMol | reagent to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.

Preparation of the In Vivo Formulation:

1) Add 100 μL of the DMSO TargetMol | reagent stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.

2) Add 50 μL Tween 80 and mix well until fully clarified.

3) Add 450 μL Saline,PBS or ddH₂O TargetMol | reagent and mix thoroughly until a homogeneous solution is obtained.

This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.

All co-solvents required for this protocol, includingDMSO, PEG300/PEG400, Tween 80, SBE-β-CD, and Corn oil, are available for purchase on the TargetMol website.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc

Keywords

PB-1PB1PB 1

PB1

PB1

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