Powder: -20°C for 3 years | In solvent: -80°C for 1 year
PD-1/PD-L1-IN-14 (compound 17) is an inhibitor of PD-1/PD-L1 interaction (IC50=27.8 nM). By inhibiting the interaction of PD-1/PD-L1, PD-1/PD-L1-IN-14 promotes dimerization, endocytosis and degradation of PD-L1.
Pack Size | Availability | Price/USD | Quantity |
---|---|---|---|
25 mg | 6-8 weeks | $ 1,520.00 | |
50 mg | 6-8 weeks | $ 1,980.00 | |
100 mg | 6-8 weeks | $ 2,500.00 |
Description | PD-1/PD-L1-IN-14 (compound 17) is an inhibitor of PD-1/PD-L1 interaction (IC50=27.8 nM). By inhibiting the interaction of PD-1/PD-L1, PD-1/PD-L1-IN-14 promotes dimerization, endocytosis and degradation of PD-L1. |
In vitro | Compound 17 (PD-1/PD-L1-IN-14) facilitates the internalization of PD-L1 from the cell surface into the cytosol and triggers its degradation in tumor cells via a lysosome-dependent pathway [1]. |
Molecular Weight | 400.47 |
Formula | C24H24N4O2 |
CAS No. | 2499965-12-5 |
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
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PD-1/PD-L1-IN-14 2499965-12-5 inhibitor inhibit