YAP-TEAD-IN-1 TFA

Name: YAP-TEAD-IN-1 TFA
Brand: TargetMol
SKU: TP2160L
Rating: 4.5 (1 reviews)

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Catalog No. TP2160LCas No. 1659305-79-9

YAP-TEAD-IN-1 TFA, a competitive inhibitor of the YAP–TEAD interaction (IC50: 25 nM), exhibits higher binding affinity to TEAD1 (Kd: 15 nM) compared to YAP (50-171) (Kd: 40 nM).

YAP-TEAD-IN-1 TFA

😃Good

Catalog No. TP2160LCas No. 1659305-79-9

YAP-TEAD-IN-1 TFA, a competitive inhibitor of the YAP–TEAD interaction (IC50: 25 nM), exhibits higher binding affinity to TEAD1 (Kd: 15 nM) compared to YAP (50-171) (Kd: 40 nM).

Pack Size	Price	USA Warehouse	Global Warehouse
1 mg	$150	7-10 days	7-10 days
5 mg	$344	7-10 days	7-10 days
10 mg	$571	7-10 days	7-10 days

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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]

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Product Introduction

Bioactivity

Description	YAP-TEAD-IN-1 TFA, a competitive inhibitor of the YAP–TEAD interaction (IC50: 25 nM), exhibits higher binding affinity to TEAD1 (Kd: 15 nM) compared to YAP (50-171) (Kd: 40 nM).
Targets&IC50	YAP-TEAD:25 nM
In vitro	In a GST pull-down assay, YAP-TEAD-IN-1 (2 μM) is against endogenous YAP binding to GST-TEAD (1209-426), the Kd of His-YAP1209-426 is determined to be 40 nM.

Chemical Properties

Formula	C₉₃H₁₄₄ClN₂₃O₂₁S₂.xC₂HF₃O₂
Cas No.	1659305-79-9
Smiles	C(C(O)=O)(F)(F)F.C(=O)([C@H]1N(C([C@@H](NC(=O)[C@H]2NC(=O)[C@H](CC3=CC=CC=C3)NC(=O)[C@H](CO)NC(=O)[C@H](C)NC(=O)[C@]4(N(C(=O)[C@H](CCCC)NC(=O)[C@H](CCCCN)NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@H](CC(C)C)NC(=O)[C@@H](NC([C@@H](NC(=O)[C@H]5N(C([C@@H](NC(C)=O)C(C)C)=O)CCC5)CC6=CC(Cl)=CC=C6)=O)CCSSC2)CCC4)[H])CCCCN)=O)CCC1)N7[C@H](C(N[C@@H](CCC(O)=O)C(N)=O)=O)CCC7
Relative Density.	1.31g/cm3
Sequence	Ac-Val-Pro-{Phe(3-Cl)}-{Hcy}-Leu-Arg-Lys-{Nle}-Pro-Ala-Ser-Phe-Cys-Lys-Pro-Pro-Glu-NH2 (Disulfide bridge:Hcy4-Cys13)
Sequence Short	Ac-VP-{Phe(3-Cl)}-{Hcy}-LRK-{Nle}-PASFCKPPE-NH2 (Disulfide bridge:Hcy4-Cys13)

Storage & Solubility Information

Storage

keep away from moisture | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

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Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:

For example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . TargetMol | Animal experiments

A total of 10 animals were administered, and the formula you used is 5% TargetMol | reagent

DMSO+30% PEG300+5% Tween 80+60% Saline /PBS/ddH₂O. So your working solution concentration is 2 mg/mL。

Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO TargetMol | reagent

(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.

Preparation method for in vivo formula: Take 50 μL DMSO TargetMol | reagent

main solution, add 300 μLPEG300 TargetMol | reagent

mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLSaline /PBS/ddH₂O TargetMol | reagent

mix well and clarify

For Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.

All types of co-solvents required for the protocol, such asDMSO, PEG300/ PEG400, Tween 80, SBE-β-CD, corn oil are available for purchase on the TargetMol website with a simple click.

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Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc