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SQ109

Name: SQ109
Brand: TargetMol
SKU: T16925
Price: 50 USD
Availability: InStock
Rating: 5 (10 reviews)

(Synonyms: NSC 722041) Copy Product Info

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Synonyms: NSC 722041

Catalog No. T16925 Copy Product Info

Purity: 99.91%

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SQ109 (NSC 722041) is an ethambutol (EMB) derivative and a specific inhibitor of MmpL3, exhibiting potent anti-Mycobacterium tuberculosis activity. SQ109 effectively inhibits the adult stage of the parasite Trypanosoma and kills cells, with an IC50 of 50 ± 8 nM. SQ109 can be used in tuberculosis and antiparasitic research.

Cas No. 502487-67-4

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Pack Size	Price	USA Stock	Global Stock
1 mg	$50	-	In Stock
5 mg	$118	In Stock	In Stock
10 mg	$182	In Stock	In Stock
25 mg	$367	In Stock	In Stock
50 mg	$548	In Stock	In Stock
100 mg	$828	In Stock	In Stock
1 mL x 10 mM (in DMSO)	$128	-	In Stock

For In stock only · Estimated delivery: USA Stock (1-2 days) Global Stock (5-7 days)

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For research use only—not for human use. No sales to individuals. Use as intended only.

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Purity:99.91%

Appearance:Viscous

Color:Transparent to Yellow

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COA LCMS HNMR

Product Introduction

Bioactivity

Description	SQ109 (NSC 722041) is an ethambutol (EMB) derivative and a specific inhibitor of MmpL3, exhibiting potent anti-Mycobacterium tuberculosis activity. SQ109 effectively inhibits the adult stage of the parasite Trypanosoma and kills cells, with an IC50 of 50 ± 8 nM. SQ109 can be used in tuberculosis and antiparasitic research.
Targets & IC50	CYP142:52 ± 11 µM (Kd), ferredoxin (Trichomonas vaginalis):3.15 µM, CYP125:41 ± 3 µM (Kd), Parasite:50 nM (trypomastigote cell), CYP124:3.4 ± 0.3 µM (Kd)
In vitro	Methods: Peritoneal macrophages from mice were infected with M.tb H37Rv (MOI 1:10). After infection, cells were treated with SQ109 (5 μM, 10 μM) for 24 hours, lysed, and plated for CFU counting. Results: SQ109 concentration-dependently reduced intracellular viable bacteria, confirming its ability to enhance macrophage killing of M.tb. [1]
In vivo	Methods: C57BL/6J mice were aerosol-inoculated with a low dose of M.tb H37Rv (110 CFU/lung). Starting on day 15 post-infection, SQ109 (10 mg/kg body weight) was administered via intraperitoneal injection daily until the euthanasia time points (days 22 and 35 post-infection). Results: SQ109 significantly reduced bacterial load in lungs and spleen. Lung histopathology revealed decreased inflammatory and necrotic lesions. [1] Methods: New Zealand White rabbits were infected with M.tb H37Rv to form humanized tuberculous granulomas with cellular margins and caseous necrosis cores. SQ109 was administered at 40 mg/kg daily for 7 consecutive days. Plasma, lung tissue, isolated cellular lesion areas, and caseous necrosis foci were collected for drug concentration measurement. Results: SQ109 accumulates extensively in lung tissue and areas of cellular lesions, with a penetration coefficient >1000. Passive diffusion is slow in caseous necrosis lesions, and drug concentrations are low, suggesting that several weeks of administration are required to achieve steady state.[2]
Synonyms	NSC 722041

Chemical Properties

Molecular Weight	330.55
Formula	C₂₂H₃₈N₂
Cas No.	502487-67-4
Smiles	CC(C)=CCC\C(C)=C\CNCCNC1C2CC3CC(C2)CC1C3
Relative Density.	0.97 g/cm3 (Predicted)

Storage & Solubility Information

Storage

Pure form: -20°C for 3 years | In solvent: -80°C for 1 year Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 21 mg/mL (63.53 mM), Sonication is recommended.

In Vivo Formulation

10% DMSO+40% PEG300+5% Tween 80+45% Saline: 2 mg/mL (6.05 mM), Sonication is recommended.

Please add the solvents sequentially, clarifying the solution as much as possible before adding the next one. Dissolve by heating and/or sonication if necessary. Working solution is recommended to be prepared and used immediately. The formulation provided above is for reference purposes only. In vivo formulations may vary and should be modified based on specific experimental conditions.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	3.0253 mL	15.1263 mL	30.2526 mL	151.2630 mL
5 mM	0.6051 mL	3.0253 mL	6.0505 mL	30.2526 mL
10 mM	0.3025 mL	1.5126 mL	3.0253 mL	15.1263 mL
20 mM	0.1513 mL	0.7563 mL	1.5126 mL	7.5632 mL
50 mM	0.0605 mL	0.3025 mL	0.6051 mL	3.0253 mL

Note : The dilution table applies only to solid products. For liquid products, please calculate the stock solution based on the stated concentration and/or density.

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:

For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, TargetMol | Animal experiments

and a total of 10 animals are to be administered, using a formulation of TargetMol | reagent

10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH₂O , the resulting working solution concentration would be 2 mg/mL.

Stock Solution Preparation:

Dissolve 2 mg of the compound in 100 μL DMSO TargetMol | reagent to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.

Preparation of the In Vivo Formulation:

1) Add 100 μL of the DMSO TargetMol | reagent stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.

2) Add 50 μL Tween 80 and mix well until fully clarified.

3) Add 450 μL Saline,PBS or ddH₂O TargetMol | reagent and mix thoroughly until a homogeneous solution is obtained.

This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.

All co-solvents required for this protocol, includingDMSO, PEG300/PEG400, Tween 80, SBE-β-CD, and Corn oil, are available for purchase on the TargetMol website.