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Anti-virus agent 1

Catalog No. T39335 CAS 1911578-83-0

Synonyms: Anti-virus agent 1, Remdesivir isopropyl ester analog

Anti-virus agent 1 (compound 4i), a phosphoramidate prodrug of GS-5734, exhibits potent antiviral efficacy. It is primarily utilized in the study of coronavirus and Ebola virus (EBOV).

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Anti-virus agent 1, CAS 1911578-83-0

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Biological Description

Chemical Properties

Storage & Solubility Information

Description	Anti-virus agent 1 (compound 4i), a phosphoramidate prodrug of GS-5734, exhibits potent antiviral efficacy. It is primarily utilized in the study of coronavirus and Ebola virus (EBOV).
In vitro	Anti-virus agent 1 (compound 4i) exhibits antiviral properties against EBOV in various cell lines, including HeLa cells [EC 50 =1845 nM], TERT-immortalized human foreskin microvascular endothelial (HMVEC) cells (ATCC-4025) [EC 50 =367 nM], and human macrophages [EC 50 =297 nM]. It possesses a cytotoxic concentration (CC 50) of 21 μM in MT4 cells (human leukemia T-cell)[1].

Synonyms	Anti-virus agent 1, Remdesivir isopropyl ester analog
Molecular Weight	560.504
Formula	C24H29N6O8P
CAS No.	1911578-83-0

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year

References and Literature

1. Dustin Siegel , et al. Discovery and Synthesis of a Phosphoramidate Prodrug of a Pyrrolo[2,1-f][triazin-4-amino] Adenine C-Nucleoside (GS-5734) for the Treatment of Ebola and Emerging Viruses. J Med Chem. 2017 Mar 9;60(5):1648-1661. 2. Michael O' Neil Hanrahan Clarke, et al.Methods for treating arenaviridae and coronaviridae virus infections. US20170071964A1.

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Method for preparing DMSO master liquid: mg drug pre-dissolved in μL DMSO (Master liquid concentration mg/mL)，Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug.

Method for preparing in vivo formulation：Take μL DMSO master liquid, next add μL PEG300， mix and clarify, next add μL Tween 80，mix and clarify, next add μL ddH₂O, mix and clarify.

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Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc.

Keywords

Anti-virus agent 1 1911578-83-0 Anti virus agent 1 Remdesivir isopropyl ester analog Antivirus agent 1 inhibitor inhibit

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