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Anti-Jagged 1 Antibody-PE (7Z938)
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Catalog No. TMAY-01963P
Alias JAGL1, Jagged 1, HJ1, CD339, AWS, AHD, AGS
Anti-Jagged 1 Antibody-PE (7Z938) is a PE-conjugated Mouse antibody targeting Jagged 1. Anti-Jagged 1 Antibody-PE (7Z938) can be used in FCM.
Anti-Jagged 1 Antibody-PE (7Z938)
Anti-Jagged 1 Antibody-PE (7Z938)
😃Good
Catalog No. TMAY-01963PAlias JAGL1, Jagged 1, HJ1, CD339, AWS, AHD, AGS
Anti-Jagged 1 Antibody-PE (7Z938) is a PE-conjugated Mouse antibody targeting Jagged 1. Anti-Jagged 1 Antibody-PE (7Z938) can be used in FCM.
| Pack Size | Price | Availability | Quantity |
|---|---|---|---|
| 25 T | $81 | 7-10 days | |
| 100 T | $104 | 7-10 days |
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Product Introduction
Bioactivity
Related Conjugates and Formulations
Antigen Details
Chemical Properties
| Description | Antibody Type: Mouse Monoclonal Application: FCM Reactivity: Human |
| Alias | JAGL1, Jagged 1, HJ1, CD339, AWS, AHD, AGS |
| Ig Type | Mouse IgG2a |
| Clone | 7Z938 |
| Reactivity | Human |
| Verified Activity | Profile of anti-JAG1(CD339) reactivity on HepG2 cells analyzed by flow cytometry. |
| Application | FCM |
| Recommended Dose | 5 μl/Test, 0.1 mg/ml |
| Antibody Type | Monoclonal |
| Host Species | Mouse |
| Construction | This antibody was produced from a hybridoma resulting from the fusion of a mouse myeloma with B cells obtained from a mouse immunized with purified, recombinant Human JAG1 / Jagged 1 (rh JAG1 / Jagged 1; TMPY-01475; NP_000205.1; Met1-Ser1046) and conjugated with PE under optimum conditions, the unreacted PE was removed. |
| Purification | Protein A |
| Appearance | Liquid |
| Formulation | PBS solution containing 0.5% BSA and 0.03%ProClin300 |
| Research Background | Protein Jagged 1, also known as JAG1, JAGL1, and CD339, is a single-pass type I membrane protein that contains 1 DSL domain and 15 EGF-like domains. JAG1/Jagged 1 is widely expressed in adult and fetal tissues. The expression of JAG1/Jagged 1 is up-regulated in cervical squamous cell carcinoma. JAG1/Jagged 1 is also expressed in bone marrow cell line HS-27a which supports the long-term maintenance of immature progenitor cells. JAG1/Jagged 1 is a ligand for multiple Notch receptors. It is involved in the mediation of Notch signaling. JAG1/Jagged 1 may be involved in cell-fate decisions during hematopoiesis. JAG1/Jagged 1 seems to be involved in the early and late stages of mammalian cardiovascular development. It inhibits myoblast differentiation and enhances fibroblast growth factor-induced angiogenesis. Defects in JAG1/Jagged 1 are the cause of Alagille syndrome type 1 (ALGS1). Alagille syndrome is an autosomal dominant multisystem disorder defined clinically by hepatic bile duct paucity and cholestasis in association with cardiac, skeletal, and ophthalmologic manifestations. Defects in JAG1/Jagged 1 are also a cause of tetralogy of Fallot (TOF). TOF is a congenital heart anomaly that consists of pulmonary stenosis, ventricular septal defect, dextroposition of the aorta (aorta is on the right side instead of the left), and hypertrophy of the right ventricle. This condition results in a blue baby at birth due to inadequate oxygenation. |
| Conjucates | PE |
| Immunogen | Recombinant Protein: Human JAG1 / Jagged 1 protein (TMPY-01475) |
| Antigen Species | Human |
| Biology Area | Notch Pathway |
Stability & Storage
| Stability & Storage | Store at 2°C-8°C for 12 months, do not freeze. Keep away from direct sunlight. |
| Transport | Shipping with blue ice. |
Sci Citations
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Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc
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