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BAY-524

Name: BAY-524
Brand: TargetMol
SKU: T14505
Price: 93 USD
Availability: InStock
Rating: 5 (10 reviews)

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Catalog No. T14505 Copy Product Info

Purity: 99.57%

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BAY-524 belongs to small molecule inhibitors and is a Bub1 kinase inhibitor (IC50 = 450 nM under 2 mM ATP conditions) with good cell permeability and selectivity. This compound demonstrates antitumor potential and can be used in research on combination anticancer therapy.

Cas No. 1445830-39-6

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Pack Size	Price	USA Stock	Global Stock
1 mg	$93	-	In Stock
5 mg	$196	-	In Stock
10 mg	$331	-	In Stock
25 mg	$535	-	In Stock
50 mg	$732	-	In Stock
100 mg	$990	-	In Stock
1 mL x 10 mM (in DMSO)	$198	-	In Stock

For In stock only · Estimated delivery: USA Stock (1-2 days) Global Stock (5-7 days)

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With extensive experience in compound synthesis, we can provide rapid custom synthesis services for this product according to your research needs.

For research use only—not for human use. No sales to individuals. Use as intended only.

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Purity:99.57%

Appearance:Solid

Color:White

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COA LCMS

Product Introduction

Bioactivity

Description	BAY-524 belongs to small molecule inhibitors and is a Bub1 kinase inhibitor (IC50 = 450 nM under 2 mM ATP conditions) with good cell permeability and selectivity. This compound demonstrates antitumor potential and can be used in research on combination anticancer therapy.
Targets & IC50	Bub1, 2 mM ATP (human):450 nM
In vitro	Methods: Human Bub1 recombinant catalytic domain and various cell models were treated with different concentrations of BAY-524 (0-30 μM) for different durations (1-48 h) to detect kinase activity, Sgo1/Sgo2 localization, chromatid cohesion, chromosomal passenger complex (CPC) localization and activity, centromere binding, spindle assembly checkpoint (SAC) signaling, and cellular sensitivity to low-dose paclitaxel in combination. Results: BAY-524 inhibited the human Bub1 recombinant catalytic domain (IC50 = 450 nM) and specifically inhibited Bub1 kinase; affected Sgo1/Sgo2 localization and chromatid cohesion; influenced CPC localization and activity; produced additive effects on centromere binding; had a minor effect on SAC signaling; and sensitized cells to low-dose paclitaxel. [1]

Chemical Properties

Molecular Weight	482.48
Formula	C₂₄H₂₄F₂N₆O₃
Cas No.	1445830-39-6
Smiles	CCOc1cc(F)c(Cn2nc(c(C)c2OC)-c2ncc(OC)c(Nc3ccncc3)n2)c(F)c1
Relative Density.	1.33 g/cm3 (Predicted)

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 150 mg/mL (310.89 mM), Sonication is recommended.

In Vivo Formulation

10% DMSO+40% PEG300+5% Tween 80+45% Saline: 5 mg/mL (10.36 mM), Sonication is recommended.

Please add the solvents sequentially, clarifying the solution as much as possible before adding the next one. Dissolve by heating and/or sonication if necessary. Working solution is recommended to be prepared and used immediately. The formulation provided above is for reference purposes only. In vivo formulations may vary and should be modified based on specific experimental conditions.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	2.0726 mL	10.3631 mL	20.7262 mL	103.6312 mL
5 mM	0.4145 mL	2.0726 mL	4.1452 mL	20.7262 mL
10 mM	0.2073 mL	1.0363 mL	2.0726 mL	10.3631 mL
20 mM	0.1036 mL	0.5182 mL	1.0363 mL	5.1816 mL
50 mM	0.0415 mL	0.2073 mL	0.4145 mL	2.0726 mL
100 mM	0.0207 mL	0.1036 mL	0.2073 mL	1.0363 mL

Note : The dilution table applies only to solid products. For liquid products, please calculate the stock solution based on the stated concentration and/or density.

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:

For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, TargetMol | Animal experiments

and a total of 10 animals are to be administered, using a formulation of TargetMol | reagent

10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH₂O , the resulting working solution concentration would be 2 mg/mL.

Stock Solution Preparation:

Dissolve 2 mg of the compound in 100 μL DMSO TargetMol | reagent to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.

Preparation of the In Vivo Formulation:

1) Add 100 μL of the DMSO TargetMol | reagent stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.

2) Add 50 μL Tween 80 and mix well until fully clarified.

3) Add 450 μL Saline,PBS or ddH₂O TargetMol | reagent and mix thoroughly until a homogeneous solution is obtained.

This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.

All co-solvents required for this protocol, includingDMSO, PEG300/PEG400, Tween 80, SBE-β-CD, and Corn oil, are available for purchase on the TargetMol website.