BMVC

Name: BMVC
Brand: TargetMol
SKU: T10574
Rating: 4.5 (1 reviews)

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Catalog No. T10574Cas No. 627810-06-4

BMVC is a potent G-quadruplex (G4) stabilizer and a selective telomerase inhibitor (IC50: ~0.2 μM) with anticancer activities, and it also inhibits Taq DNA polymerase (IC50: ~2.5 μM).

BMVC

😃Good

Catalog No. T10574Cas No. 627810-06-4

BMVC is a potent G-quadruplex (G4) stabilizer and a selective telomerase inhibitor (IC50: ~0.2 μM) with anticancer activities, and it also inhibits Taq DNA polymerase (IC50: ~2.5 μM).

Pack Size	Price	Availability
25 mg	$916	6-8 weeks
50 mg	$1,190	6-8 weeks
100 mg	$1,860	6-8 weeks

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Product Introduction

Bioactivity

Description	BMVC is a potent G-quadruplex (G4) stabilizer and a selective telomerase inhibitor (IC50: ~0.2 μM) with anticancer activities, and it also inhibits Taq DNA polymerase (IC50: ~2.5 μM).
Targets&IC50	G-quadruplex:~2.5 μM , Telomerase:~0.2 μM
In vitro	BMVC (0.5 μM; 0-18 days; H1299 cells) treatment significantly increases the percentage of sub-G1-phase cells after 18 days, leading to cessation of cell growth and cell death through apoptosis. Long-term BMVC treatment induces senescence, accompanied by progressive telomere shortening and DNA damage foci detection, indicating telomere uncapping [1].
In vivo	The treatment of BMVC (1 mg/kg; i.p.; every 3 day; BALB/cAnN.Cg-Foxn1nu/CrlNarl mice) delays tumorigenic potential of cancer cells in vivo [1].

Chemical Properties

Molecular Weight	657.33
Formula	C₂₈H₂₅I₂N₃
Cas No.	627810-06-4
Relative Density.	no data available

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Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

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Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO TargetMol | reagent

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Preparation method for in vivo formula: Take 50 μL DMSO TargetMol | reagent

main solution, add 300 μLPEG300 TargetMol | reagent

mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLSaline/PBS/ddH₂O TargetMol | reagent

mix well and clarify

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