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Anti-C9orf72 Monoclonal Antibody (1M713)
(Synonyms: FTDALS1, FTDALS, DENNL72, DENND9, ALSFTD) Copy Product Info
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Synonyms: FTDALS1, FTDALS, DENNL72, DENND9, ALSFTD
Catalog No. TMAT-0197 Copy Product Info
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Anti-C9orf72 Monoclonal Antibody (1M713) is a Mouse antibody targeting C9orf72. Anti-C9orf72 Monoclonal Antibody (1M713) can be used in WB,IHC,IF,FCM.
Anti-C9orf72 Monoclonal Antibody
(1M713)
| Pack Size | Price | USA Stock | Global Stock | Quantity |
|---|---|---|---|---|
| 20 µL | Inquiry | 7-10 days | 7-10 days | |
| 50 µL | Inquiry | 7-10 days | 7-10 days | |
| 100 µL | Inquiry | 7-10 days | 7-10 days |
For In stock only · Estimated delivery: USA Stock (1-2 days) Global Stock (5-7 days)
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For research use only—not for human use. No sales to individuals. Use as intended only.
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Product Introduction
Bioactivity
Related Conjugates and Formulations
Antigen Details
Stability & Storage
| Description | Anti-C9orf72 Monoclonal Antibody (1M713) is a Mouse antibody targeting C9orf72. Anti-C9orf72 Monoclonal Antibody (1M713) can be used in WB,IHC,IF,FCM. |
| Synonyms | FTDALS1, FTDALS, DENNL72, DENND9, ALSFTD |
| Ig Type | IgG2b |
| Clone | 1M713 |
| Reactivity | Human, Mouse, Monkey, Rat |
| Application | |
| Recommended Dose | WB: 1/500-1/2000; IHC: 1/200-1/1000; IF: 1/200-1/1000; FCM: 1/200-1/400 |
| Antibody Type | Monoclonal |
| Host Species | Mouse |
| Construction | Hybridoma Monoclonal Antibody |
| Purification | Purified by protein A or protein G |
| Appearance | Liquid |
| Formulation | PBS with 0.05% sodium azide |
| Concentration | 1 mg/ml |
| Research Background | The protein encoded by this gene plays an important role in the regulation of endosomal trafficking, and has been shown to interact with Rab proteins that are involved in autophagy and endocytic transport. Expansion of a GGGGCC repeat from 2-22 copies to 700-1600 copies in the intronic sequence between alternate 5' exons in transcripts from this gene is associated with 9p-linked ALS (amyotrophic lateral sclerosis) and FTD (frontotemporal dementia) (PMID: 21944778, 21944779). Studies suggest that hexanucleotide expansions could result in the selective stabilization of repeat-containing pre-mRNA, and the accumulation of insoluble dipeptide repeat protein aggregates that could be pathogenic in FTD-ALS patients (PMID: 23393093). Alternative splicing results in multiple transcript variants encoding different isoforms. |
| Conjucates | Unconjugated |
| Immunogen | Purified recombinant fragment of human C9orf72 (AA: 110-199) expressed in E. Coli. |
| Antigen Species | Human |
| Gene Name | C9orf72 |
| Gene ID | |
| Protein Name | Guanine nucleotide exchange C9orf72 |
| Uniprot ID |
| Stability & Storage | Store at -20°C or -80°C for 12 months. Avoid repeated freeze-thaw cycles. |
| Transport | Shipping with blue ice. |
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