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Mizagliflozin
🥰Excellent
Catalog No. T16083Cas No. 666843-10-3
Alias KGA-3235 free base, GSK-1614235 free base, DSP-3235 free base
Mizagliflozin is an orally active, selective SGLT1 inhibitor with a Ki value of 27 nM for human SGLT1. Mizagliflozin is 303 times more selective for SGLT1 than for SGLT2. Mizagliflozin is an anti-diabetic drug that can improve postprandial blood sugar fluctuations and may have the potential to improve chronic constipation.
Mizagliflozin
🥰Excellent
Purity: 99.67%
Catalog No. T16083Alias KGA-3235 free base, GSK-1614235 free base, DSP-3235 free baseCas No. 666843-10-3
Mizagliflozin is an orally active, selective SGLT1 inhibitor with a Ki value of 27 nM for human SGLT1. Mizagliflozin is 303 times more selective for SGLT1 than for SGLT2. Mizagliflozin is an anti-diabetic drug that can improve postprandial blood sugar fluctuations and may have the potential to improve chronic constipation.
| Pack Size | Price | Availability | Quantity |
|---|---|---|---|
| 1 mg | $64 | In Stock | |
| 2 mg | $93 | In Stock | |
| 5 mg | $155 | In Stock | |
| 10 mg | $248 | In Stock | |
| 25 mg | $492 | In Stock | |
| 50 mg | $713 | In Stock | |
| 100 mg | $987 | In Stock | |
| 200 mg | $1,380 | In Stock | |
| 1 mL x 10 mM (in DMSO) | $193 | In Stock |
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Purity:99.67%
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Product Introduction
Bioactivity
Chemical Properties
| Description | Mizagliflozin is an orally active, selective SGLT1 inhibitor with a Ki value of 27 nM for human SGLT1. Mizagliflozin is 303 times more selective for SGLT1 than for SGLT2. Mizagliflozin is an anti-diabetic drug that can improve postprandial blood sugar fluctuations and may have the potential to improve chronic constipation. |
| Targets&IC50 | SGLT2 (human):8170 nM(ki), SGLT1 (human):(ki)27 nM |
| In vivo | METHODS: Mizagliflozin (GSK-1614235 free base) (0.3 mg/kg, intravenous administration) and oral administration (3 mg/kg, oral administration) were administered to rats to study its pharmacokinetics and metabolite profile. RESULTS Mizagliflozin had different half-lives in rats (0.23 and 1.14 hours, respectively) depending on the administration route; the absolute bioavailability was only 0.02%; after oral administration, Mizagliflozin was mainly metabolized to its aglycone KP232 in the intestine. [2] |
| Synonyms | KGA-3235 free base, GSK-1614235 free base, DSP-3235 free base |
| Molecular Weight | 564.67 |
| Formula | C28H44N4O8 |
| Cas No. | 666843-10-3 |
| Smiles | CC(C)c1[nH]nc(O[C@@H]2O[C@H](CO)[C@@H](O)[C@H](O)[C@H]2O)c1Cc1ccc(OCCCNCC(C)(C)C(N)=O)cc1C |
| Relative Density. | 1.274 g/cm3 (Predicted) |
| Color | White |
| Appearance | Solid |
Storage & Solubility Information
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature. | |||||||||||||||||||||||||||||||||||
| Solubility Information | Methanol: 250 mg/mL (442.74 mM), Sonication is recommended. DMSO: 100 mg/mL (177.09 mM), Sonication is recommended. | |||||||||||||||||||||||||||||||||||
Solution Preparation Table | ||||||||||||||||||||||||||||||||||||
DMSO/Methanol
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In Vivo Formulation Calculator (Clear solution)
Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:
For example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . A total of 10 animals were administered, and the formula you used is 5% 
DMSO+30% PEG300+5% Tween 80+60% Saline/PBS/ddH2O. So your working solution concentration is 2 mg/mL。Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO (mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.
(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.Preparation method for in vivo formula: Take 50 μL DMSO main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLSaline/PBS/ddH2O mix well and clarify
main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLSaline/PBS/ddH2O mix well and clarifyFor Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.
Dose Conversion
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Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc
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