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YE6144 free base
Catalog No. T215025 Copy Product Info
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YE6144 free base is a selective prototype inhibitor of interferon regulatory factor 5 (IRF5). It has demonstrated the ability to suppress disease progression in mouse models of systemic lupus erythematosus (SLE) and is particularly effective in maintaining remission. This compound can be utilized for SLE research.
YE6144 free base
Copy Product Info🥰Excellent
Catalog No. T215025
YE6144 free base is a selective prototype inhibitor of interferon regulatory factor 5 (IRF5). It has demonstrated the ability to suppress disease progression in mouse models of systemic lupus erythematosus (SLE) and is particularly effective in maintaining remission. This compound can be utilized for SLE research.
YE6144 free base
Cas No. 3065657-01-1
| Pack Size | Price | USA Stock | Global Stock | Quantity |
|---|---|---|---|---|
| 10 mg | Inquiry | 10-14 weeks | 10-14 weeks | |
| 50 mg | Inquiry | 10-14 weeks | 10-14 weeks |
For In stock only · Estimated delivery: USA Stock (1-2 days) Global Stock (5-7 days)
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For research use only—not for human use. No sales to individuals. Use as intended only.
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Product Introduction
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Storage & Solubility Information
| Description | YE6144 free base is a selective prototype inhibitor of interferon regulatory factor 5 (IRF5). It has demonstrated the ability to suppress disease progression in mouse models of systemic lupus erythematosus (SLE) and is particularly effective in maintaining remission. This compound can be utilized for SLE research. |
| In vitro | YE6144 is a free base compound that, at concentrations of 1 or 3 μM for 30 minutes, can inhibit the phosphorylation of IRF5 in human peripheral blood mononuclear cells (PBMC) and mouse spleen cells. Additionally, YE6144 at concentrations ranging from 0 to 10 μM for 30 minutes suppresses the production of type I interferon (IFN) in healthy control (HC) human PBMC, with an IC50 value of approximately 0.09 μM. |
| In vivo | YE6144, as a free base administered via a single subcutaneous injection at 40.0 mg/kg, can inhibit the progression of systemic lupus erythematosus in mice. |
| Molecular Weight | 411.49 |
| Formula | C21H26FN7O |
| Cas No. | 3065657-01-1 |
| Smiles | C(=C/C1=CC=C(N=N1)N2CCOCC2)\C=3C=4C(=CC(F)=C(NC[C@H](CC)N)C4)NN3 |
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year Shipping with blue ice/Shipping at ambient temperature. |
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In Vivo Formulation Calculator (Clear solution)
Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:
For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, and a total of 10 animals are to be administered, using a formulation of 
10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH2O , the resulting working solution concentration would be 2 mg/mL.Stock Solution Preparation:
Dissolve 2 mg of the compound in 100 μL DMSO to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.
Preparation of the In Vivo Formulation:
1) Add 100 μL of the DMSO stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.
2) Add 50 μL Tween 80 and mix well until fully clarified.
3) Add 450 μL Saline,PBS or ddH2O and mix thoroughly until a homogeneous solution is obtained.
This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.
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Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc
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