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DRF-1042

🥰Excellent
Catalog No. T15168Cas No. 200619-13-2

DRF-1042, an orally active camptothecin analog, exhibits anticancer and insecticidal activities by inhibiting DNA topoisomerase I. It has been studied for its efficacy against solid tumors, including prostate and colon cancers.

DRF-1042
Other Forms of DRF-1042:
DRF-1042 HClT15168L
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DRF-1042

🥰Excellent
Purity: 98.34%
Catalog No. T15168Cas No. 200619-13-2
DRF-1042, an orally active camptothecin analog, exhibits anticancer and insecticidal activities by inhibiting DNA topoisomerase I. It has been studied for its efficacy against solid tumors, including prostate and colon cancers.
Pack SizePriceUSA WarehouseGlobal WarehouseQuantity
1 mg$30In StockIn Stock
5 mg$64In StockIn Stock
10 mg$106In StockIn Stock
25 mg$218In StockIn Stock
50 mg$348In StockIn Stock
1 mL x 10 mM (in DMSO)$71In StockIn Stock
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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]
This molecule is a custom-made product. TargetMol has an excellent synthesis team with the experience and capability to provide you with cost-effective products. However, due to objective factors, there is a small probability that the synthesis may not be successful during the R&D process. We appreciate your understanding. If you have any questions, please feel free to contact us. We are committed to serving you wholeheartedly.
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Batch Information

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Purity:98.34%
ee:95.17%
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Product Introduction

Bioactivity
Description
DRF-1042, an orally active camptothecin analog, exhibits anticancer and insecticidal activities by inhibiting DNA topoisomerase I. It has been studied for its efficacy against solid tumors, including prostate and colon cancers.
In vitro
DRF-1042 displays excellent endostatin stability and good in vitro anticancer activity. It confronts a range of human cancer cell lines including multi-drug resistant (MDR) phenotypes [2].
In vivo
DRF-1042 treatment showed adverse myelosuppressive effects in clone formation assays against mouse, canine and human bone marrow cells. This supports the possibility of extending the dosing schedule in experimental and clinical studies [2].
Chemical Properties
Molecular Weight408.4
FormulaC22H20N2O6
Cas No.200619-13-2
SmilesCC[C@@]1(O)C(=O)OCc2c1cc1-c3nc4ccccc4cc3C(OCCO)n1c2=O
Relative Density.1.53 g/cm3 (Predicted)
Storage & Solubility Information
Storagestore under nitrogen | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.
Solubility Information
DMSO: 30 mg/mL (73.46 mM), Sonication is recommended.
In Vivo Formulation
10% DMSO+40% PEG300+5% Tween 80+45% Saline: 2 mg/mL (4.9 mM), Sonication is recommended.
Please add the solvents sequentially, clarifying the solution as much as possible before adding the next one. Dissolve by heating and/or sonication if necessary. Working solution is recommended to be prepared and used immediately. The formulation provided above is for reference purposes only. In vivo formulations may vary and should be modified based on specific experimental conditions.
Solution Preparation Table
DMSO
1mg5mg10mg50mg
1 mM2.4486 mL12.2429 mL24.4858 mL122.4290 mL
5 mM0.4897 mL2.4486 mL4.8972 mL24.4858 mL
10 mM0.2449 mL1.2243 mL2.4486 mL12.2429 mL
20 mM0.1224 mL0.6121 mL1.2243 mL6.1214 mL
50 mM0.0490 mL0.2449 mL0.4897 mL2.4486 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:
TargetMol | Animal experimentsFor example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . TargetMol | Animal experiments A total of 10 animals were administered, and the formula you used is 5% TargetMol | reagent DMSO+30% PEG300+5% Tween 80+60% Saline/PBS/ddH2O. So your working solution concentration is 2 mg/mL。
Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSOTargetMol | reagent (mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.
Preparation method for in vivo formula: Take 50 μL DMSOTargetMol | reagent main solution, add 300 μLPEG300TargetMol | reagent mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLSaline/PBS/ddH2OTargetMol | reagent mix well and clarify
For Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.
All types of co-solvents required for the protocol, such asDMSO, PEG300/ PEG400, Tween 80, SBE-β-CD, corn oil are available for purchase on the TargetMol website with a simple click.
1 Enter information below:
mg/kg
g
μL
2 Enter the in vivo formulation:
% DMSO
%
% Tween 80
% Saline/PBS/ddH2O

Dose Conversion

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Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc

Keywords

TopoDRF-1042DRF1042DRF 1042DNA topoisomerase I
Related Tags: buy DRF-1042 | purchase DRF-1042 | DRF-1042 cost | order DRF-1042 | DRF-1042 chemical structure | DRF-1042 in vivo | DRF-1042 in vitro | DRF-1042 formula | DRF-1042 molecular weight
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