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Nalidixic acid

Name: Nalidixic acid
Brand: TargetMol
SKU: T0909
Price: 30 USD
Availability: InStock
Rating: 5 (10 reviews)

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Catalog No. T0909Cas No. 389-08-2

Alias NSC-82174

Nalidixic acid (NSC-82174) is a synthetic 1, 8-naphthyridine antimicrobial agent with a limited bacteriocidal spectrum. It is an inhibitor of the A subunit of bacterial DNA GYRASE.

Nalidixic acid

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Purity: 99.95%

Catalog No. T0909Alias NSC-82174Cas No. 389-08-2

Nalidixic acid (NSC-82174) is a synthetic 1, 8-naphthyridine antimicrobial agent with a limited bacteriocidal spectrum. It is an inhibitor of the A subunit of bacterial DNA GYRASE.

Pack Size	Price	USA Warehouse	Global Warehouse	Quantity
5 g	$30	-	In Stock
1 mL x 10 mM (in DMSO)	$32	In Stock	In Stock

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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]

All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.

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Purity:99.95%

Color:White

Resource Download

COA HNMR HPLC

Product Introduction

Nalidixic acid AI Summary

Nalidixic acid is a potential antibacterial agent exhibiting a broad spectrum of activity against various gram-negative and gram-positive bacteria. It demonstrates notable efficacy against Escherichia coli by inhibiting DNA gyrase supercoiling with an IC50 value of 52.0 µg/mL and moderate to low MIC values ranging from 1.0 µg/mL to >256.0 µg/mL depending on the strain and resistance profile. Its antibacterial activity extends to pathogens such as Klebsiella pneumoniae, Proteus mirabilis, Staphylococcus aureus, Pseudomonas aeruginosa, and others, with varying MIC values. Nalidixic acid also shows efficacy in mouse models of lethal infections caused by Escherichia coli and Streptococcus aureus, indicating its potential for therapeutic applications. Additionally, it inhibits Bacillus subtilis topoisomerase 4 with an IC50 of 34.6 µg/mL and exhibits dose-dependent antimicrobial effects against Vibrio splendidus and other bacteria harboring resistance determinants. Its broad activity spectrum and efficacy in inhibiting DNA gyrase and topoisomerases highlight its promise as a potent antibacterial agent..

Note: Summary generated by AI. Data source: ChEMBL

Bioactivity

Description	Nalidixic acid (NSC-82174) is a synthetic 1, 8-naphthyridine antimicrobial agent with a limited bacteriocidal spectrum. It is an inhibitor of the A subunit of bacterial DNA GYRASE.
Synonyms	NSC-82174

Chemical Properties

Molecular Weight	232.24
Formula	C₁₂H₁₂N₂O₃
Cas No.	389-08-2
Smiles	CCN1C=C(C(O)=O)C(=O)C2=CC=C(C)N=C12
Relative Density.	1.331 g/cm3

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

H2O: < 1 mg/mL (insoluble or slightly soluble)

Ethanol: < 1 mg/mL (insoluble or slightly soluble)

DMSO: 5.63 mg/mL (24.24 mM), Sonication is recommended.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	4.3059 mL	21.5295 mL	43.0589 mL	215.2945 mL
5 mM	0.8612 mL	4.3059 mL	8.6118 mL	43.0589 mL
10 mM	0.4306 mL	2.1529 mL	4.3059 mL	21.5295 mL
20 mM	0.2153 mL	1.0765 mL	2.1529 mL	10.7647 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:

For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, TargetMol | Animal experiments

and a total of 10 animals are to be administered, using a formulation of TargetMol | reagent

10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH₂O , the resulting working solution concentration would be 2 mg/mL.

Stock Solution Preparation:

Dissolve 2 mg of the compound in 100 μL DMSO TargetMol | reagent to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.

Preparation of the In Vivo Formulation:

1) Add 100 μL of the DMSO TargetMol | reagent stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.

2) Add 50 μL Tween 80 and mix well until fully clarified.

3) Add 450 μL Saline,PBS or ddH₂O TargetMol | reagent and mix thoroughly until a homogeneous solution is obtained.

This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.

All co-solvents required for this protocol, includingDMSO, PEG300/PEG400, Tween 80, SBE-β-CD, and Corn oil, are available for purchase on the TargetMol website.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc