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GST

Glutathione S-transferases (GSTs), previously known as ligandins, comprise a family of eukaryotic and prokaryotic phase II metabolic isozymes best known for their ability to catalyze the conjugation of the reduced form of glutathione (GSH) to xenobiotic substrates for the purpose of detoxification.

  • 7-Acetoxy-4-methylcoumarin
    T70372747-05-9
    7-Acetoxy-4-methylcoumarin is a fluorescent substrate for carboxylesterases and acts as an inhibitor of GST, which can be isolated from Trigonella foenum graceum and inhibits AFB1-DNA binding.
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  • α-Vitamin E
    T164859-02-9
    α-Vitamin E (Dexrabeprazole Sodium) is a naturally-occurring form of vitamin E, a fat-soluble vitamin with potent antioxidant properties.
    • $38
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  • Ezatiostat TFA
    T5862
    Ezatiostat TFA (TLK199) is a liposomal small-molecule glutathione analog inhibitor of glutathione S-transferase (GST) P1-1 with hematopoiesis-stimulating activity.
    • $50
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  • Trans-Methylisoeugenol
    TN51666379-72-2
    Trans-Methylisoeugenol is a compound with insecticidal activity isolated from Acorus calamus L. It is a natural food flavor. It is a natural food flavor with anxiolytic and antidepressant properties and moderately reversible inhibition of glutathione S-transferases (GSTs) (0.2 to 5.4 mmol for human GSTs and 0.4 to 4.9 mmol for rat GSTs).
    • $84
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  • Ethacrynic acid
    T456458-54-8
    Ethacrynic acid (Edecrin) is a nonsulfonamide loop diuretic that inhibits the activity of the Na+/K+/2Cl- cotransporter NKCC2 in the thick ascending limb of the loop of Henle. It also inhibits glutathione S-transferase and Wnt signalling, producing cytotoxicity in chronic lymphocytic leukaemia cells and other tumour cells.
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  • GSTO-IN-2
    T115041202710-57-3
    GSTO-IN-2 is a glutathione S-transferase (GST) inhibitor that inhibits GSTA2, GSTM1, and GSTP1-1, and can be used for tumor research.
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  • α-Angelica lactone
    T7995591-12-8
    α-Angelica lactone has cardiotonic activity, may exert their effects by providing an increased contraction-dependent calcium pool to be released upon systolic depolarization.
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  • Ezatiostat
    T5097168682-53-9
    Ezatiostat (TER199(free base)) is a tripeptide analog of glutathione that can selectively inhibit GSTP1-1 catalytic activity.
    • $31
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  • Seneciphylline
    TN1078480-81-9
    Seneciphylline, one of the hepatotoxic pyrolizidine alkaloids, has mutagenic activity in Drosophila and their transfer into rat milk.Seneciphylline can significantly increased the activities of epoxide hydrase and glutathione-S-transferase but cause reduc
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  • coniferyl ferulate
    T3S001263644-62-2
    Coniferyl ferulate is a strong inhibitor of glutathione S-transferase (GST) isolated from Radix Angelicae sinensis. It shows strong inhibition of human placental GST (IC50: 0.3 μM). It also reverses multidrug resistance and downregulates P-glycoprotein.
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  • Clomipramine hydrochloride
    T025517321-77-6
    Clomipramine hydrochloride (Anafranil) is a tricyclic antidepressant similar to IMIPRAMINE that selectively inhibits the uptake of serotonin in the brain. It is readily absorbed from the gastrointestinal tract and demethylated in the liver to form its primary active metabolite, desmethylclomipramine.
    • $32
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  • GSTO1-IN-1
    T11505568544-03-6
    GSTO1-IN-1 is a potent glutathione S-transferase omega 1 inhibitor (GSTO1; IC50: 31 nM).
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  • Curzerene
    T3S054117910-09-7
    Curzerene, a sesquiterpene compound derived from the rhizome of Curculigo orchioides Gaertn, possesses potent anti-cancer properties. It is known to induce apoptosis in cells[1] and also suppress the expression of glutathione S-transferase A1 (GSTA1) mRNA and protein.
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