Shopping Cart
  • Remove All
  • TargetMol
    Your shopping cart is currently empty

GST

Glutathione S-transferases (GSTs), previously known as ligandins, comprise a family of eukaryotic and prokaryotic phase II metabolic isozymes best known for their ability to catalyze the conjugation of the reduced form of glutathione (GSH) to xenobiotic substrates for the purpose of detoxification.

(-)-Anonaine
TN13931862-41-5In house
(-)-Anonaine can be extracted from several species of Magnoliaceae and Annelidae and has antimalarial, antibacterial, antifungal, antioxidant, anticancer, antidepressant and vasodilatory activities. (-)-Anonaine induces apoptosis in human cervical cancer (HeLa) cells, induces DNA damage and inhibits the growth and migration of human lung cancer h1299 cells through Bax and caspase-dependent pathways.
  • $340
In Stock
Size
QTY
Mithramycin A
T553018378-89-7
Mithramycin A (Plicamycin), a DNA-binding antitumor antibiotic, is a selective specificity protein 1 (Sp1) inhibitor, which inhibits the growth of various cancers by decreasing Sp1 protein. Specificity protein 1 (Sp1) is a zinc-finger transcription factor that regulates multiple cellular functions and promotes tumor progression.
  • $139
In Stock
Size
QTY
NBDHEX
T12189787634-60-0
NBDHEX is a potent inhibitor of glutathione S-transferase P1-1 (GSTP1-1) .
  • $30
In Stock
Size
QTY
TargetMol | Inhibitor Sale
7-Acetoxy-4-methylcoumarin
T70372747-05-9
7-Acetoxy-4-methylcoumarin is a fluorescent substrate for carboxylesterases and acts as an inhibitor of GST, which can be isolated from Trigonella foenum graceum and inhibits AFB1-DNA binding.
  • $29
In Stock
Size
QTY
α-Vitamin E
T164859-02-9
α-Vitamin E (Dexrabeprazole Sodium) is a naturally-occurring form of vitamin E, a fat-soluble vitamin with potent antioxidant properties.
  • $38
In Stock
Size
QTY
TargetMol | Citations Cited
coniferyl ferulate
T3S001263644-62-2
Coniferyl ferulate is a strong inhibitor of glutathione S-transferase (GST) isolated from Radix Angelicae sinensis. It shows strong inhibition of human placental GST (IC50: 0.3 μM). It also reverses multidrug resistance and downregulates P-glycoprotein.
  • $64
In Stock
Size
QTY
GSTO-IN-2
T115041202710-57-3
GSTO-IN-2 is a glutathione S-transferase inhibitor with IC50 values of 1.4 μM for GSTP1-1, 16.3 μM for GSTM1, and 3.6 μM for GSTA2.
  • $599
In Stock
Size
QTY
GSTO1-IN-1
T11505568544-03-6
GSTO1-IN-1 is a potent glutathione S-transferase omega 1 inhibitor (GSTO1) with an IC50 of 31 nM.
  • $30
In Stock
Size
QTY
TargetMol | Inhibitor Sale
TLK117
T8424152684-53-2
TLK117 is an inhibitor of GSTs that reduces the severity of pulmonary fibrosis and can be used to study idiopathic pulmonary fibrosis.
  • $149
In Stock
Size
QTY
Ethacrynic acid
T456458-54-8
Ethacrynic acid (Edecrin) is a nonsulfonamide loop diuretic that inhibits the activity of the Na+ K+ 2Cl- cotransporter NKCC2 in the thick ascending limb of the loop of Henle. It also inhibits glutathione S-transferase and Wnt signalling, producing cytotoxicity in chronic lymphocytic leukaemia cells and other tumour cells.
  • $31
In Stock
Size
QTY
TargetMol | Citations Cited
Seneciphylline
TN1078480-81-9
Seneciphylline, one of the hepatotoxic pyrolizidine alkaloids, has mutagenic activity in Drosophila and their transfer into rat milk.Seneciphylline can significantly increased the activities of epoxide hydrase and glutathione-S-transferase but cause reduc
  • $48
In Stock
Size
QTY
TargetMol | Inhibitor Sale
Trans-Methylisoeugenol
TN51666379-72-2
Trans-Methylisoeugenol is a compound with insecticidal activity isolated from Acorus calamus L. It is a natural food flavor. It is a natural food flavor with anxiolytic and antidepressant properties and moderately reversible inhibition of glutathione S-transferases (GSTs) (0.2 to 5.4 mmol for human GSTs and 0.4 to 4.9 mmol for rat GSTs).
  • $84
In Stock
Size
QTY
Bicyclol
T4121118159-48-1
Bicyclol (SY801)(SY 801) is an anti-hepatitis drug. Oral administration of bicyclol normalizes the elevated serum transaminases (ALT, AST) by 50% in chronic viral hepatitis B and C, and also has a certain level of inhibiting HBV and HCV replication. In combination therapy of bicyclol with interferon alpha, lamivudine and adefovir dipivoxil in HBV or HCV, bicyclol may reduce YMDD mutant and side effects and increase the anti-viral efficacy.
  • $57
In Stock
Size
QTY
TargetMol | Citations Cited
Erucin
T272824430-36-8
Erucin (1-isothiocyanato-4-methylsulfanylbutane) is a dietary isothiocyanate produced by enzymatic hydrolysis of glucoErucin with potential cancer preventive effects, involved in apoptosis and cell cycle blockade through PARP-1 cleavage, p53 and p21,Cyp450, quinone reductase (QR), glutatione transferase (GST) and other pathways.
  • $42
In Stock
Size
QTY
LAS17
T399062362527-67-9
LAS17 is a selective and highly effective inhibitor of glutathione S-transferase Pi (GSTP1), which inhibits GSTP1 activity in vitro in a concentration-dependent manner. LAS17 has anti-tumor activity and inhibits breast cancer cell growth.
  • $249
In Stock
Size
QTY
Clomipramine hydrochloride
T025517321-77-6
Clomipramine hydrochloride (Anafranil) is a tricyclic antidepressant similar to IMIPRAMINE that selectively inhibits the uptake of serotonin in the brain. It is readily absorbed from the gastrointestinal tract and demethylated in the liver to form its primary active metabolite, desmethylclomipramine.
  • $30
In Stock
Size
QTY
Ezatiostat
T5097168682-53-9
Ezatiostat (TER199(free base)) is a tripeptide analog of glutathione that can selectively inhibit GSTP1-1 catalytic activity.
  • $35
In Stock
Size
QTY
Benoxacor
T1980598730-04-2
Benoxacor (BRN-4190275) is an inert agricultural chemical. Benoxacor acts as an herbicide safener to protect crops from herbicide toxicity.
  • $42
In Stock
Size
QTY
α-Angelica lactone
T7995591-12-8
α-Angelica lactone has cardiotonic activity, may exert their effects by providing an increased contraction-dependent calcium pool to be released upon systolic depolarization.
  • $29
Backorder
Size
QTY
Ezatiostat TFA
T5862
Ezatiostat TFA (TLK199) is a liposomal small-molecule glutathione analog inhibitor of glutathione S-transferase (GST) P1-1 with hematopoiesis-stimulating activity.
  • $50
In Stock
Size
QTY
2,2'-Dihydroxy chalcone
TN722415131-80-3
2,2'-Dihydroxy chalcone is a potent inhibitor of β-glucuronidase (IC50=1.6±0.2 μM) and lysozyme (IC50=1.4±0.2 μM) release from rat neutrophils stimulated with fMLP CB.2,2'-Dihydroxy chalcone has inhibitory activity against Escherichia coli, Shigella fowleri, Staphylococcus albicans and Staphylococcus aureus.
  • $82
In Stock
Size
QTY
TargetMol | Inhibitor Sale
GJG057
T2052472761767-18-2
GJG057 is a highly efficient and selective Leukotriene C4 synthase (LTC4S) inhibitor with an IC50 of 44 nM in human whole blood LTC4 release assays and oral activity. It demonstrates anti-inflammatory efficacy in a mouse asthma exacerbation model and can be used for the treatment of allergic inflammation.
  • $168
In Stock
Size
QTY
AZD9898
T143872042347-69-1
AZD9898 is an inhibitor of leukotriene-C4 synthetase with an IC50 of 0.28 nM. AZD9898 can be used in studies about asthma. AZD9898 mitigates the GABA binding and hepatic toxicity signal.
  • $215
In Stock
Size
QTY
Curzerene
T3S054117910-09-7
Curzerene, a sesquiterpene compound derived from the rhizome of Curculigo orchioides Gaertn, possesses potent anti-cancer properties. It is known to induce apoptosis in cells[1] and also suppress the expression of glutathione S-transferase A1 (GSTA1) mRNA and protein.
  • $44
In Stock
Size
QTY
TargetMol | Inhibitor Sale