9A1P9

Name: 9A1P9
Brand: TargetMol
SKU: T84640
Rating: 4.5 (1 reviews)

(Synonyms: 9A1P9) Copy Product Info

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Synonyms: 9A1P9

Catalog No. T84640 Copy Product Info

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9A1P9 is a multi-tailed ionizable cationic lipid featuring multiple hydrophobic chains and a protonatable headgroup. Under acidic conditions, 9A1P9 enhances electrostatic interactions with nucleic acids, promotes endosomal escape, and improves intracellular mRNA delivery efficiency. 9A1P9 is commonly used in the construction of lipid nanoparticle (LNP) systems and in delivery mechanism studies.

Cas No. 2760467-57-8

Pack Size	Price	USA Stock	Global Stock	Quantity
1 mg	$162	8-10 weeks	8-10 weeks
5 mg (20.34 mM * 500 μL in Ethanol)	$392	-	In Stock

For In stock only · Estimated delivery: USA Stock (1-2 days) Global Stock (5-7 days)

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For research use only—not for human use. No sales to individuals. Use as intended only.

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Appearance:Liquid

Color:Transparent

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Product Introduction

Bioactivity

Description	9A1P9 is a multi-tailed ionizable cationic lipid featuring multiple hydrophobic chains and a protonatable headgroup. Under acidic conditions, 9A1P9 enhances electrostatic interactions with nucleic acids, promotes endosomal escape, and improves intracellular mRNA delivery efficiency. 9A1P9 is commonly used in the construction of lipid nanoparticle (LNP) systems and in delivery mechanism studies.
In vitro	Compared to neutral pH, 9A1P9 exhibits higher membrane-lysing activity in acidic intracellular compartments [2].
In vivo	9A1P9 enables efficient mRNA delivery in mice, with iPLNP formulations prepared at a molar ratio of 9A1P9 to Fluc mRNA of 11,622:1, and a weight ratio of 9A1P9 to RNA of 18:1 [2].
Synonyms	9A1P9

Chemical Properties

Molecular Weight	491.73
Formula	C₂₇H₅₈NO₄P
Cas No.	2760467-57-8
Smiles	O=P(O)(OCCN(CCCCCCCC)CCCCCCCC)OCCCCCCCCC

Storage & Solubility Information

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Powder: -20°C for 3 years | In solvent: -80°C for 1 year Shipping with blue ice/Shipping at ambient temperature.

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:

For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, TargetMol | Animal experiments

and a total of 10 animals are to be administered, using a formulation of TargetMol | reagent

10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH₂O , the resulting working solution concentration would be 2 mg/mL.

Stock Solution Preparation:

Dissolve 2 mg of the compound in 100 μL DMSO TargetMol | reagent to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.

Preparation of the In Vivo Formulation:

1) Add 100 μL of the DMSO TargetMol | reagent stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.

2) Add 50 μL Tween 80 and mix well until fully clarified.

3) Add 450 μL Saline,PBS or ddH₂O TargetMol | reagent and mix thoroughly until a homogeneous solution is obtained.

This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.

All co-solvents required for this protocol, includingDMSO, PEG300/PEG400, Tween 80, SBE-β-CD, and Corn oil, are available for purchase on the TargetMol website.