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Thiocolchicoside

Name: Thiocolchicoside
Brand: TargetMol
SKU: T2S1464
Price: 39 USD
Availability: InStock
Rating: 5 (10 reviews)

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Catalog No. T2S1464Cas No. 602-41-5

Alias Thiocolchicine 2-glucoside analog, Coltramyl

Thiocolchicoside (Thiocolchicine 2-glucoside analog) (Muscoril, Myoril, Neoflax) is a muscle relaxant with anti-inflammatory and analgesic effects. It acts as a competitive GABAA receptor antagonist and also glycine receptor antagonist with similar potency and nicotinic acetylcholine receptors to a much lesser extent. It has powerful convulsant activity and should not be used in seizure-prone individuals.

Thiocolchicoside

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Purity: 99.39%

Catalog No. T2S1464Alias Thiocolchicine 2-glucoside analog, ColtramylCas No. 602-41-5

Pack Size	Price	USA Warehouse	Global Warehouse
10 mg	$39	In Stock	In Stock
25 mg	$67	In Stock	In Stock
50 mg	$98	In Stock	In Stock
100 mg	$147	In Stock	In Stock
200 mg	$218	-	In Stock

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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]

All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.

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Batch Information

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Purity:99.39%

Color:White

Resource Download

COA LCMS HNMR HPLC

Product Introduction

Thiocolchicoside AI Summary

Thiocolchicoside exhibits multiple bioactivities across various biological targets. It displaces [3H]strychnine from strychnine-sensitive glycine receptors in rat spinal cord with an IC50 of 1500.0 nM and [3H]muscimol from GABA-A receptors in both Sprague-Dawley rat spinal cord (IC50 = 1900.0 nM) and cerebral cortex (IC50 = 3400.0 nM). Additionally, it inhibits Histone Lysine Methyltransferase G9a (IC50 = 12589.3 nM), BAZ2B (IC50 = 1258.9 nM), and various other targets such as HP1-beta Chromodomain, malaria parasite plastid, and histone tails, albeit with higher IC50 values indicating lower potency. The compound shows low inhibitory activity against human BSEP in Sf9 cell membrane vesicles with IC50 > 133,000 nM. While also demonstrating limited antiviral activity against SARS-CoV-2 in multiple assays, the effectiveness remains low with IC50 values indicating limited potency. Thiocolchicoside moderately inhibits human HDAC6 activity using a commercial peptide substrate (22.0%) but has no significant inhibitory effect with a custom peptide. Overall, it exhibits weak interactions and limited effectiveness across various assays..

Note: Summary generated by AI. Data source: ChEMBL

Bioactivity

Description

Synonyms

Thiocolchicine 2-glucoside analog, Coltramyl

Chemical Properties

Molecular Weight	563.62
Formula	C₂₇H₃₃NO₁₀S
Cas No.	602-41-5
Smiles	COc1c(O[C@@H]2O[C@H](CO)[C@@H](O)[C@H](O)[C@H]2O)cc2CC[C@H](NC(C)=O)c3cc(=O)c(SC)ccc3-c2c1OC
Relative Density.	1.2222 g/cm3 (Estimated)

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

H2O: 177.4 mM, Sonication is recommended.

DMSO: 55 mg/mL (97.58 mM), Sonication is recommended.

In Vivo Formulation

10% DMSO+40% PEG300+5% Tween 80+45% Saline: 2 mg/mL (3.55 mM), Sonication is recommended.

Please add the solvents sequentially, clarifying the solution as much as possible before adding the next one. Dissolve by heating and/or sonication if necessary. Working solution is recommended to be prepared and used immediately. The formulation provided above is for reference purposes only. In vivo formulations may vary and should be modified based on specific experimental conditions.

Solution Preparation Table

DMSO/H2O

	1mg	5mg	10mg	50mg
1 mM	1.7742 mL	8.8712 mL	17.7425 mL	88.7123 mL
5 mM	0.3548 mL	1.7742 mL	3.5485 mL	17.7425 mL
10 mM	0.1774 mL	0.8871 mL	1.7742 mL	8.8712 mL
20 mM	0.0887 mL	0.4436 mL	0.8871 mL	4.4356 mL
50 mM	0.0355 mL	0.1774 mL	0.3548 mL	1.7742 mL

H2O

	1mg	5mg	10mg	50mg
100 mM	0.0177 mL	0.0887 mL	0.1774 mL	0.8871 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:

For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, TargetMol | Animal experiments

and a total of 10 animals are to be administered, using a formulation of TargetMol | reagent

10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH₂O , the resulting working solution concentration would be 2 mg/mL.

Stock Solution Preparation:

Dissolve 2 mg of the compound in 100 μL DMSO TargetMol | reagent to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.

Preparation of the In Vivo Formulation:

1) Add 100 μL of the DMSO TargetMol | reagent stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.

2) Add 50 μL Tween 80 and mix well until fully clarified.

3) Add 450 μL Saline,PBS or ddH₂O TargetMol | reagent and mix thoroughly until a homogeneous solution is obtained.

This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.

All co-solvents required for this protocol, includingDMSO, PEG300/PEG400, Tween 80, SBE-β-CD, and Corn oil, are available for purchase on the TargetMol website.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc