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Anti-GPX4 Antibody (8O208)
😃Good
Catalog No. TMAH-00510
Alias snPHGPx, snGPx, PHGPx, NEDSGA, MCSP, GSHPx-4, GPx-4, GLURD, GLUR4C, GLUR4, GluA4
Anti-GPX4 Antibody (8O208) is an antibody targeting GPX4. Anti-GPX4 Antibody (8O208) can be used in ELISA, IHC.
Anti-GPX4 Antibody (8O208)
Anti-GPX4 Antibody (8O208)
😃Good
Catalog No. TMAH-00510Alias snPHGPx, snGPx, PHGPx, NEDSGA, MCSP, GSHPx-4, GPx-4, GLURD, GLUR4C, GLUR4, GluA4
Anti-GPX4 Antibody (8O208) is an antibody targeting GPX4. Anti-GPX4 Antibody (8O208) can be used in ELISA, IHC.
| Pack Size | Price | Availability | Quantity |
|---|---|---|---|
| 50 μL | $208 | 7-10 days | |
| 100 μL | $349 | 7-10 days |
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Product Introduction
Bioactivity
Related Conjugates and Formulations
Antigen Details
Chemical Properties
| Description | Antibody Type: Recombinant Monoclonal Application: ELISA, IHC Reactivity: Human |
| Alias | snPHGPx, snGPx, PHGPx, NEDSGA, MCSP, GSHPx-4, GPx-4, GLURD, GLUR4C, GLUR4, GluA4 |
| Ig Type | Rabbit IgG |
| Clone | 8O208 |
| Reactivity | Human |
| Verified Activity | IHC image of TMAH-00510 diluted at 1:100 and staining in paraffin-embedded human kidney tissue performed on a Leica BondTM system. After dewaxing and hydration, antigen retrieval was mediated by high pressure in a citrate buffer (pH 6.0). Section was blocked with 10% normal goat serum 30min at RT. Then primary antibody (1% BSA) was incubated at 4°C overnight. The primary is detected by a Goat anti-rabbit IgG polymer labeled by HRP and visualized using 0.05% DAB. |
| Application | ELISA, IHC |
| Recommended Dose | IHC:1:50-1:200. |
| Antibody Type | Monoclonal |
| Subcellular Localization | [Isoform Mitochondrial]: Mitochondrion.; [Isoform Cytoplasmic]: Cytoplasm. |
| Construction | Recombinant Antibody |
| Purification | Affinity-chromatography |
| Appearance | Liquid |
| Formulation | Phosphate buffered saline, pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol. |
| Research Background | Essential antioxidant peroxidase that directly reduces phospholipid hydroperoxide even if they are incorporated in membranes and lipoproteins. Can also reduce fatty acid hydroperoxide, cholesterol hydroperoxide and thymine hydroperoxide. Plays a key role in protecting cells from oxidative damage by preventing membrane lipid peroxidation. Required to prevent cells from ferroptosis, a non-apoptotic cell death resulting from an iron-dependent accumulation of lipid reactive oxygen species. The presence of selenocysteine (Sec) versus Cys at the active site is essential for life: it provides resistance to overoxidation and prevents cells against ferroptosis. The presence of Sec at the active site is also essential for the survival of a specific type of parvalbumin-positive interneurons, thereby preventing against fatal epileptic seizures. May be required to protect cells from the toxicity of ingested lipid hydroperoxides. Required for normal sperm development and male fertility. Essential for maturation and survival of photoreceptor cells. Plays a role in a primary T-cell response to viral and parasitic infection by protecting T-cells from ferroptosis and by supporting T-cell expansion. Plays a role of glutathione peroxidase in platelets in the arachidonic acid metabolism. Reduces hydroperoxy ester lipids formed by a 15-lipoxygenase that may play a role as down-regulator of the cellular 15-lipoxygenase pathway. |
| Conjucates | Unconjugated |
| Immunogen | A synthetic peptide: Human GPX4 |
| Antigen Species | Human |
| Gene ID | 2879 |
| Uniprot ID | |
| Biology Area | Cancer, Metabolism, Signal transduction |
Stability & Storage
| Stability & Storage | Store at -20°C or -80°C for 12 months. Avoid repeated freeze-thaw cycles. |
| Transport | Shipping with blue ice. |
Sci Citations
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Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc
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