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PPY A

🥰Excellent
Catalog No. T23182Cas No. 875634-01-8

PPY A is a potent inhibitor of T315l mutant and wild-type Abl kinase (IC50 of 9 and 20 nM, respectively).PPY A also inhibits the growth of Bcr-Abl T315l mutant or wild-type Bcr-Abl genetically transformed cells.

PPY A

PPY A

🥰Excellent
Purity: 98.77%
Catalog No. T23182Cas No. 875634-01-8
PPY A is a potent inhibitor of T315l mutant and wild-type Abl kinase (IC50 of 9 and 20 nM, respectively).PPY A also inhibits the growth of Bcr-Abl T315l mutant or wild-type Bcr-Abl genetically transformed cells.
Pack SizePriceAvailabilityQuantity
1 mg$95In Stock
5 mg$237In Stock
10 mg$388In Stock
25 mg$588In Stock
50 mg$798In Stock
100 mg$1,070In Stock
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Purity:98.77%
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Product Introduction

Bioactivity
Description
PPY A is a potent inhibitor of T315l mutant and wild-type Abl kinase (IC50 of 9 and 20 nM, respectively).PPY A also inhibits the growth of Bcr-Abl T315l mutant or wild-type Bcr-Abl genetically transformed cells.
Chemical Properties
Molecular Weight372.42
FormulaC22H20N4O2
Cas No.875634-01-8
SmilesO=C(C1=CN=CC(=C1)C2=CN=C3NC=C(C=4C=CC=CC4OC)C3=C2)N(C)C
Relative Density.1.248 g/cm3 (Predicted)
Storage & Solubility Information
Storagestore at low temperature,keep away from direct sunlight | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.
Solubility Information
DMSO: 10 mg/mL (26.85 mM), Sonication is recommended.
Solution Preparation Table
DMSO
1mg5mg10mg50mg
1 mM2.6851 mL13.4257 mL26.8514 mL134.2570 mL
5 mM0.5370 mL2.6851 mL5.3703 mL26.8514 mL
10 mM0.2685 mL1.3426 mL2.6851 mL13.4257 mL
20 mM0.1343 mL0.6713 mL1.3426 mL6.7129 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:
TargetMol | Animal experimentsFor example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . TargetMol | Animal experiments A total of 10 animals were administered, and the formula you used is 5% TargetMol | reagent DMSO+30% PEG300+5% Tween 80+60% Saline/PBS/ddH2O. So your working solution concentration is 2 mg/mL。
Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSOTargetMol | reagent (mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.
Preparation method for in vivo formula: Take 50 μL DMSOTargetMol | reagent main solution, add 300 μLPEG300TargetMol | reagent mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLSaline/PBS/ddH2OTargetMol | reagent mix well and clarify
For Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.
All types of co-solvents required for the protocol, such asDMSO, PEG300/ PEG400, Tween 80, SBE-β-CD, corn oil are available for purchase on the TargetMol website with a simple click.
1 Enter information below:
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2 Enter the in vivo formulation:
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Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc

Keywords

PPY ABcr-Abl1BcrAbl
Related Tags: buy PPY A | purchase PPY A | PPY A cost | order PPY A | PPY A chemical structure | PPY A formula | PPY A molecular weight
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