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Cevipabulin fumarate

Name: Cevipabulin fumarate
Brand: TargetMol
SKU: T10772L
Rating: 4.5 (1 reviews)

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Catalog No. T10772LCas No. 849550-67-0

Alias TTI-237 fumarate

Cevipabulin (TTI-237) fumarate is a microtubule-active antitumor compound and inhibits the binding of [3H] vinblastine to tubulin (IC50: 18-40 nM in the human tumor cell line).

Cevipabulin fumarate

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Catalog No. T10772LAlias TTI-237 fumarateCas No. 849550-67-0

Cevipabulin (TTI-237) fumarate is a microtubule-active antitumor compound and inhibits the binding of [3H] vinblastine to tubulin (IC50: 18-40 nM in the human tumor cell line).

Pack Size	Price	USA Warehouse	Global Warehouse
5 mg	$125	7-10 days	7-10 days
10 mg	$214	7-10 days	7-10 days
20 mg	$450	7-10 days	7-10 days
50 mg	$720	7-10 days	7-10 days

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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]

All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.

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Product Introduction

Bioactivity

Description	Cevipabulin (TTI-237) fumarate is a microtubule-active antitumor compound and inhibits the binding of [3H] vinblastine to tubulin (IC50: 18-40 nM in the human tumor cell line).
Targets&IC50	Microtubule (human tumor cells):18-40 nM
In vitro	Cevipabulin (0-50 nM, 72 hours) exhibits potent activity (IC50s: 18-40 nM) on ovarian, breast, prostate, and cervical tumor cell lines. At low concentrations (20-40 nM), it induces sub-G1 nuclei, while concentrations above 50 nM result in a significant G2-M block [1].
In vivo	In mice, Cevipabulin ( 5, 10, 15, and 20 mg/kg, every 4 days for 4 cycles; i.v. and p.o.) is active against human tumor xenografts and showing dose-dependent effects, with good antitumor activity at 20 and 15 mg/kg [1].
Synonyms	TTI-237 fumarate

Chemical Properties

Molecular Weight	580.89
Formula	C₂₂H₂₂ClF₅N₆O₅
Cas No.	849550-67-0
Smiles	OC(=O)\C=C\C(O)=O.CNCCCOc1cc(F)c(c(F)c1)-c1c(Cl)nc2ncnn2c1N[C@@H](C)C(F)(F)F
Relative Density.	no data available

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 50 mg/mL (86.07 mM), Sonication is recommended.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	1.7215 mL	8.6075 mL	17.2150 mL	86.0748 mL
5 mM	0.3443 mL	1.7215 mL	3.4430 mL	17.2150 mL
10 mM	0.1721 mL	0.8607 mL	1.7215 mL	8.6075 mL
20 mM	0.0861 mL	0.4304 mL	0.8607 mL	4.3037 mL
50 mM	0.0344 mL	0.1721 mL	0.3443 mL	1.7215 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:

For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, TargetMol | Animal experiments

and a total of 10 animals are to be administered, using a formulation of TargetMol | reagent

10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH₂O , the resulting working solution concentration would be 2 mg/mL.

Stock Solution Preparation:

Dissolve 2 mg of the compound in 100 μL DMSO TargetMol | reagent to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.

Preparation of the In Vivo Formulation:

1) Add 100 μL of the DMSO TargetMol | reagent stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.

2) Add 50 μL Tween 80 and mix well until fully clarified.

3) Add 450 μL Saline,PBS or ddH₂O TargetMol | reagent and mix thoroughly until a homogeneous solution is obtained.

This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.

All co-solvents required for this protocol, includingDMSO, PEG300/PEG400, Tween 80, SBE-β-CD, and Corn oil, are available for purchase on the TargetMol website.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc