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Anti-CRIP2 Antibody (5S293)
😃Good
Catalog No. TMAY-02739
Alias ESP1, cysteine-rich protein 2, CRP2, CRIP
Anti-CRIP2 Antibody (5S293) is a Mouse antibody targeting CRIP2. Anti-CRIP2 Antibody (5S293) can be used in IHC-P.
Anti-CRIP2 Antibody (5S293)
Anti-CRIP2 Antibody (5S293)
😃Good
Catalog No. TMAY-02739Alias ESP1, cysteine-rich protein 2, CRP2, CRIP
Anti-CRIP2 Antibody (5S293) is a Mouse antibody targeting CRIP2. Anti-CRIP2 Antibody (5S293) can be used in IHC-P.
| Pack Size | Price | Availability | Quantity |
|---|---|---|---|
| 100 μL | $199 | 7-10 days |
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Chemical Properties
| Description | Anti-CRIP2 Antibody (5S293) is a Mouse antibody targeting CRIP2. Anti-CRIP2 Antibody (5S293) can be used in IHC-P. |
| Alias | ESP1, cysteine-rich protein 2, CRP2, CRIP |
| Ig Type | Monoclonal Mouse IgG1 |
| Clone | 5S293 |
| Reactivity | Human |
| Verified Activity | Immunochemical staining of human CRIP2 in human placenta with mouse monoclonal antibody (1:100, formalin-fixed paraffin embedded sections). |
| Application | IHC-P |
| Recommended Dose | IHC-P: 1:50-1:200 |
| Antibody Type | Monoclonal |
| Host Species | Mouse |
| Construction | This antibody was produced from a hybridoma resulting from the fusion of a mouse myeloma with B cells obtained from a mouse immunized with purified, recombinant Human CRIP2 (rh CRIP2; TMPY-03342; P52943; Met1-Pro208). The IgG fraction of the cell culture supernatant was purified by Protein A affinity chromatography. |
| Purification | Protein A |
| Appearance | Liquid |
| Formulation | 0.2 μm filtered solution in PBS |
| Research Background | CRIP2 is a putative transcription factor. It has a widespread tissue expression and is highly expressed in heart. CRIP2 contains two LIM zinc-binding domains. CRIP2 may participate in the differentiation of smooth muscle tissue. It also plays an important role in esophageal squamous cell carcinoma (ESCC) tumorigenesis. CRIP2 acts as a transcription repressor of the NF-κB-mediated proangiogenic cytokine expression and thus functionally inhibits tumor formation and angiogenesis. It interacts with the NF-κB/p65 to inhibit its DNA-binding ability to the promoter regions of the major proangiogenesis cytokines critical for tumor progression, including IL6, IL8, and VEGF. In conclusion, we provide compelling evidence that CRIP2 acts as a transcription repressor of the NF-κB-mediated proangiogenic cytokine expression and thus functionally inhibits tumor formation and angiogenesis. |
| Conjucates | Unconjugated |
| Immunogen | Recombinant Human CRIP2 protein (TMPY-03342) |
| Antigen Species | Human |
Stability & Storage
| Stability & Storage | Store at 2°C-8°C for 1 month. Store at -20°C or -80°C for 12 months. Avoid repeated freeze-thaw cycles. Preservative-Free. |
| Transport | Shipping with blue ice. |
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For example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . 
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Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc
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