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Boc-C1-PEG2-C4-Cl

Name: Boc-C1-PEG2-C4-Cl
Brand: TargetMol
SKU: T18637
Rating: 4.5 (1 reviews)

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Catalog No. T18637Cas No. 1835705-53-7

Alias PROTAC Linker 1

Boc-C1-PEG2-C4-Cl (PROTAC Linker 1) is a PEG-based compound used as a linker in the synthesis and development of PROTACs[1].

Boc-C1-PEG2-C4-Cl

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Catalog No. T18637Alias PROTAC Linker 1Cas No. 1835705-53-7

Boc-C1-PEG2-C4-Cl (PROTAC Linker 1) is a PEG-based compound used as a linker in the synthesis and development of PROTACs[1].

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Product Introduction

Bioactivity

Description	Boc-C1-PEG2-C4-Cl (PROTAC Linker 1) is a PEG-based compound used as a linker in the synthesis and development of PROTACs[1].
In vitro	PROTAC technology utilizes small molecules to facilitate the ubiquitination and subsequent proteasomal degradation of target proteins. This report details the creation of PROTAC compounds designed for the degradation of c-ABL and BCR-ABL proteins by harnessing Cereblon or Von Hippel Lindau E3 ligases. The molecule Boc-C1-PEG2-C4-Cl is identified as 6-2-2[1].
Synonyms	PROTAC Linker 1

Chemical Properties

Molecular Weight	294.82
Formula	C₁₄H₂₇ClO₄
Cas No.	1835705-53-7
Smiles	O=C(OC(C)(C)C)COCCOCCCCCCCl
Relative Density.	1.026 g/cm3 (Predicted)

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 50 mg/mL (169.6 mM), Sonication is recommended.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	3.3919 mL	16.9595 mL	33.9190 mL	169.5950 mL
5 mM	0.6784 mL	3.3919 mL	6.7838 mL	33.9190 mL
10 mM	0.3392 mL	1.6960 mL	3.3919 mL	16.9595 mL
20 mM	0.1696 mL	0.8480 mL	1.6960 mL	8.4798 mL
50 mM	0.0678 mL	0.3392 mL	0.6784 mL	3.3919 mL
100 mM	0.0339 mL	0.1696 mL	0.3392 mL	1.6960 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:

For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, TargetMol | Animal experiments

and a total of 10 animals are to be administered, using a formulation of TargetMol | reagent

10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH₂O , the resulting working solution concentration would be 2 mg/mL.

Stock Solution Preparation:

Dissolve 2 mg of the compound in 100 μL DMSO TargetMol | reagent to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.

Preparation of the In Vivo Formulation:

1) Add 100 μL of the DMSO TargetMol | reagent stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.

2) Add 50 μL Tween 80 and mix well until fully clarified.

3) Add 450 μL Saline,PBS or ddH₂O TargetMol | reagent and mix thoroughly until a homogeneous solution is obtained.

This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.

All co-solvents required for this protocol, includingDMSO, PEG300/PEG400, Tween 80, SBE-β-CD, and Corn oil, are available for purchase on the TargetMol website.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc