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Boc-C1-PEG2-C4-Cl (PROTAC Linker 1) is a PEG-based compound used as a linker in the synthesis and development of PROTACs[1].
Description | Boc-C1-PEG2-C4-Cl (PROTAC Linker 1) is a PEG-based compound used as a linker in the synthesis and development of PROTACs[1]. |
In vitro | PROTAC technology utilizes small molecules to facilitate the ubiquitination and subsequent proteasomal degradation of target proteins. This report details the creation of PROTAC compounds designed for the degradation of c-ABL and BCR-ABL proteins by harnessing Cereblon or Von Hippel Lindau E3 ligases. The molecule Boc-C1-PEG2-C4-Cl is identified as 6-2-2[1]. |
Alias | PROTAC Linker 1 |
Molecular Weight | 294.82 |
Formula | C14H27ClO4 |
Cas No. | 1835705-53-7 |
Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice. | |||||||||||||||||||||||||||||||||||
Solubility Information | DMSO: 50 mg/mL (169.60 mM) | |||||||||||||||||||||||||||||||||||
Solution Preparation Table | ||||||||||||||||||||||||||||||||||||
DMSO
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