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Boc-C1-PEG2-C4-Cl

Catalog No. T18637Cas No. 1835705-53-7
Alias PROTAC Linker 1

Boc-C1-PEG2-C4-Cl (PROTAC Linker 1) is a PEG-based compound used as a linker in the synthesis and development of PROTACs[1].

Boc-C1-PEG2-C4-Cl

Boc-C1-PEG2-C4-Cl

Catalog No. T18637Alias PROTAC Linker 1Cas No. 1835705-53-7
Boc-C1-PEG2-C4-Cl (PROTAC Linker 1) is a PEG-based compound used as a linker in the synthesis and development of PROTACs[1].
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Product Introduction

Bioactivity
Description
Boc-C1-PEG2-C4-Cl (PROTAC Linker 1) is a PEG-based compound used as a linker in the synthesis and development of PROTACs[1].
In vitro
PROTAC technology utilizes small molecules to facilitate the ubiquitination and subsequent proteasomal degradation of target proteins. This report details the creation of PROTAC compounds designed for the degradation of c-ABL and BCR-ABL proteins by harnessing Cereblon or Von Hippel Lindau E3 ligases. The molecule Boc-C1-PEG2-C4-Cl is identified as 6-2-2[1].
AliasPROTAC Linker 1
Chemical Properties
Molecular Weight294.82
FormulaC14H27ClO4
Cas No.1835705-53-7
Storage & Solubility Information
StoragePowder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice.
Solubility Information
DMSO: 50 mg/mL (169.60 mM)
Solution Preparation Table
DMSO
1mg5mg10mg50mg
1 mM3.3919 mL16.9595 mL33.9190 mL169.5950 mL
5 mM0.6784 mL3.3919 mL6.7838 mL33.9190 mL
10 mM0.3392 mL1.6960 mL3.3919 mL16.9595 mL
20 mM0.1696 mL0.8480 mL1.6960 mL8.4798 mL
50 mM0.0678 mL0.3392 mL0.6784 mL3.3919 mL
100 mM0.0339 mL0.1696 mL0.3392 mL1.6960 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:
TargetMol | Animal experimentsFor example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . TargetMol | Animal experiments A total of 10 animals were administered, and the formula you used is 5% TargetMol | reagent DMSO+30% PEG300+5% Tween 80+60% ddH2O. So your working solution concentration is 2 mg/mL。
Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSOTargetMol | reagent (mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.
Preparation method for in vivo formula: Take 50 μL DMSOTargetMol | reagent main solution, add 300 μLPEG300TargetMol | reagent mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2OTargetMol | reagent mix well and clarify
For Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.
1 Enter information below:
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2 Enter the in vivo formulation:
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Dose Conversion

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Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc

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