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Delapril hydrochloride

Name: Delapril hydrochloride
Brand: TargetMol
SKU: T3281
Price: 31 USD
Availability: InStock
Rating: 5 (10 reviews)

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Catalog No. T3281Cas No. 83435-67-0

Alias indalapril, Delapril Hydrochloride, CV 3317, Alindapril Hydrochloride

Delapril hydrochloride (indalapril) is a prodrug; it is converted into two active metabolites, 5-hydroxy delapril diacid and delapril diacid. These metabolites bind completely to and inhibit angiotensin-converting enzyme (ACE), hence blocking angiotensin I to angiotensin II conversion.

Delapril hydrochloride

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Purity: 97.45%

Catalog No. T3281Alias indalapril, Delapril Hydrochloride, CV 3317, Alindapril HydrochlorideCas No. 83435-67-0

Pack Size	Price	USA Warehouse	Global Warehouse
5 mg	$31	In Stock	In Stock
10 mg	$56	In Stock	In Stock
25 mg	$113	In Stock	In Stock
50 mg	$147	In Stock	In Stock
100 mg	$197	In Stock	In Stock
1 mL x 10 mM (in DMSO)	$35	In Stock	In Stock

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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]

All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.

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Batch Information

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Purity:97.45%

Appearance:Solid

Color:White

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COA HNMR LCMS

Product Introduction

Delapril hydrochloride AI Summary

Delapril hydrochloride demonstrates bioactivity as an inhibitor in various assays, including blocking the entry of Ebola virus into cells and inhibiting human tyrosyl-DNA phosphodiesterase 1 (TDP1). It shows potency at varying concentrations in these assays, indicating potential antiviral and enzymatic inhibitory properties. However, it exhibits a low inhibition index (0.1107) in assays conducted on Vero E6 cells infected with SARS-CoV-2, showing minimal inhibition of cell viability compared to the control arbidol. Additionally, it inhibited SARS-CoV-2 induced cytotoxicity of Caco-2 cells by 26.34% at a concentration of 10 μM after 48 hours, as determined by high content imaging. Furthermore, Delapril hydrochloride has a 7.146% inhibition rate on SARS-CoV-2 3CL-Pro protease at a concentration of 20 µM, suggesting some potential bioactivity against this enzyme. However, in Vero-6 cells, it demonstrated a mere 0.03% inhibition rate at 10 μM concentration after 48 hours of exposure to the virus..

Note: Summary generated by AI. Data source: ChEMBL

Bioactivity

Description	Delapril hydrochloride (indalapril) is a prodrug; it is converted into two active metabolites, 5-hydroxy delapril diacid and delapril diacid. These metabolites bind completely to and inhibit angiotensin-converting enzyme (ACE), hence blocking angiotensin I to angiotensin II conversion.
Synonyms	indalapril, Delapril Hydrochloride, CV 3317, Alindapril Hydrochloride

Chemical Properties

Molecular Weight	489.01
Formula	C₂₆H₃₃ClN₂O₅
Cas No.	83435-67-0
Smiles	Cl.CCOC(=O)[C@H](CCc1ccccc1)N[C@@H](C)C(=O)N(CC(O)=O)C1Cc2ccccc2C1
Relative Density.	no data available

Storage & Solubility Information

Storage

store at low temperature | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 89 mg/mL (182 mM), Sonication is recommended.

In Vivo Formulation

10% DMSO+40% PEG300+5% Tween 80+45% Saline: 3.3 mg/mL (6.75 mM), Sonication is recommended.

Please add the solvents sequentially, clarifying the solution as much as possible before adding the next one. Dissolve by heating and/or sonication if necessary. Working solution is recommended to be prepared and used immediately. The formulation provided above is for reference purposes only. In vivo formulations may vary and should be modified based on specific experimental conditions.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	2.0449 mL	10.2247 mL	20.4495 mL	102.2474 mL
5 mM	0.4090 mL	2.0449 mL	4.0899 mL	20.4495 mL
10 mM	0.2045 mL	1.0225 mL	2.0449 mL	10.2247 mL
20 mM	0.1022 mL	0.5112 mL	1.0225 mL	5.1124 mL
50 mM	0.0409 mL	0.2045 mL	0.4090 mL	2.0449 mL
100 mM	0.0204 mL	0.1022 mL	0.2045 mL	1.0225 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:

For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, TargetMol | Animal experiments

and a total of 10 animals are to be administered, using a formulation of TargetMol | reagent

10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH₂O , the resulting working solution concentration would be 2 mg/mL.

Stock Solution Preparation:

Dissolve 2 mg of the compound in 100 μL DMSO TargetMol | reagent to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.

Preparation of the In Vivo Formulation:

1) Add 100 μL of the DMSO TargetMol | reagent stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.

2) Add 50 μL Tween 80 and mix well until fully clarified.

3) Add 450 μL Saline,PBS or ddH₂O TargetMol | reagent and mix thoroughly until a homogeneous solution is obtained.

This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.

All co-solvents required for this protocol, includingDMSO, PEG300/PEG400, Tween 80, SBE-β-CD, and Corn oil, are available for purchase on the TargetMol website.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc