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Pumafentrine

Name: Pumafentrine
Brand: TargetMol
SKU: T71691
Price: 195 USD
Availability: InStock
Rating: 5 (10 reviews)

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Catalog No. T71691Cas No. 207993-12-2

Alias BY 343

Pumafentrine(BY 343) is a dual PDE3/PDE4 inhibitor that reduces clinical scores and TNF expression in experimental colitis in mice.

Pumafentrine

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Purity: 99.85%

Catalog No. T71691Alias BY 343Cas No. 207993-12-2

Pumafentrine(BY 343) is a dual PDE3/PDE4 inhibitor that reduces clinical scores and TNF expression in experimental colitis in mice.

Pack Size	Price	USA Warehouse	Global Warehouse
1 mg	$195	In Stock	In Stock
5 mg	$465	In Stock	In Stock
10 mg	$679	-	In Stock
25 mg	$1,070	-	In Stock
50 mg	$1,430	-	In Stock

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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]

This molecule is a custom-made product. TargetMol has an excellent synthesis team with the experience and capability to provide you with cost-effective products. If you have any questions, please feel free to contact us. We are committed to serving you wholeheartedly.

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Batch Information

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Purity:99.85%

ee:99.77%

Appearance:Solid

Color:White

Resource Download

COA LCMS CSFC HNMR

Product Introduction

Bioactivity

Description	Pumafentrine(BY 343) is a dual PDE3/PDE4 inhibitor that reduces clinical scores and TNF expression in experimental colitis in mice.
Synonyms	BY 343

Chemical Properties

Molecular Weight	477.64
Formula	C₂₉H₃₉N₃O₃
Cas No.	207993-12-2
Smiles	O(C)C=1C=C2C([C@]3([C@@](N=C2C4=CC=C(C(N(C(C)C)C(C)C)=O)C=C4)(CCN(C)C3)[H])[H])=CC1OCC

Storage & Solubility Information

Storage

store at low temperature | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 50 mg/mL (104.68 mM), Sonication is recommended.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	2.0936 mL	10.4681 mL	20.9363 mL	104.6813 mL
5 mM	0.4187 mL	2.0936 mL	4.1873 mL	20.9363 mL
10 mM	0.2094 mL	1.0468 mL	2.0936 mL	10.4681 mL
20 mM	0.1047 mL	0.5234 mL	1.0468 mL	5.2341 mL
50 mM	0.0419 mL	0.2094 mL	0.4187 mL	2.0936 mL
100 mM	0.0209 mL	0.1047 mL	0.2094 mL	1.0468 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:

For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, TargetMol | Animal experiments

and a total of 10 animals are to be administered, using a formulation of TargetMol | reagent

10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH₂O , the resulting working solution concentration would be 2 mg/mL.

Stock Solution Preparation:

Dissolve 2 mg of the compound in 100 μL DMSO TargetMol | reagent to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.

Preparation of the In Vivo Formulation:

1) Add 100 μL of the DMSO TargetMol | reagent stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.

2) Add 50 μL Tween 80 and mix well until fully clarified.

3) Add 450 μL Saline,PBS or ddH₂O TargetMol | reagent and mix thoroughly until a homogeneous solution is obtained.

This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.

All co-solvents required for this protocol, includingDMSO, PEG300/PEG400, Tween 80, SBE-β-CD, and Corn oil, are available for purchase on the TargetMol website.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc