Shopping Cart

Remove All

Your shopping cart is currently empty

Proceed to checkout Continue shopping

DL-TBOA

Name: DL-TBOA
Brand: TargetMol
SKU: T11055
Rating: 4.5 (1 reviews)

🥰Excellent

Catalog No. T11055Cas No. 205309-81-5

Alias DLTBOA, DL TBOA

DL-TBOA is an inhibitor of excitatory amino acid transporter proteins, inhibiting excitatory amino acid transporter protein 1 (EAAT1), EAAT2, and EAAT3.

DL-TBOA

🥰Excellent

Purity: 99.60%

Catalog No. T11055Alias DLTBOA, DL TBOACas No. 205309-81-5

DL-TBOA is an inhibitor of excitatory amino acid transporter proteins, inhibiting excitatory amino acid transporter protein 1 (EAAT1), EAAT2, and EAAT3.

Product information is being updated, if you want to purchase, please click the bulk custom button.

Add to Quotation

Questions

Batch Information

Select Batch

Purity:99.60%

Resource Download

COA LCMS

Product Introduction

Bioactivity

Description	DL-TBOA is an inhibitor of excitatory amino acid transporter proteins, inhibiting excitatory amino acid transporter protein 1 (EAAT1), EAAT2, and EAAT3.
Targets&IC50	EAAT1 (human):42 μM (Ki), EAAT2 (human):5.7 μM, EAAT5:3.2 μM, EAAT1:70 μM, EAAT2:6 μM, EAAT3:6 μM, EAAT4:4.4 μM
In vitro	In HCT116 and LoVo cell lines, DL-TBOA (70 μM, 350 μM; 48 hours) enhances SN38-induced cell death and counteracts Oxaliplatin-induced cell death[4].
In vivo	In male Sprague-Dawley rats (180-250 g), DL-TBOA (1 nmol, 3 nmol, 10 nmol;i.c.v.) dose-dependently facilitated various somatic signs induced by Naloxone (0.1 mg/kg)[5].
Synonyms	DLTBOA, DL TBOA

Chemical Properties

Molecular Weight	239.22
Formula	C₁₁H₁₃NO₅
Cas No.	205309-81-5
Smiles	[C@@H]([C@@H](C(O)=O)N)(OCC1=CC=CC=C1)C(O)=O
Relative Density.	1.392 g/cm3 (Predicted)
Color	White
Appearance	Solid

Storage & Solubility Information

Storage

store at low temperature | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

H2O: 2 mg/mL (8.36 mM), Sonication is recommended.

DMSO: 100 mg/mL (418.00 mM), Sonication is recommended.

In Vivo Formulation

10% DMSO+40% PEG300+5% Tween 80+45% Saline: 5 mg/mL (20.9 mM), Sonication is recommended.

Please add the solvents sequentially, clarifying the solution as much as possible before adding the next one. Dissolve by heating and/or sonication if necessary. Working solution is recommended to be prepared and used immediately. The formulation provided above is for reference purposes only. In vivo formulations may vary and should be modified based on specific experimental conditions.

Solution Preparation Table

H2O/DMSO

	1mg	5mg	10mg	50mg
1 mM	4.1803 mL	20.9013 mL	41.8025 mL	209.0126 mL
5 mM	0.8361 mL	4.1803 mL	8.3605 mL	41.8025 mL

DMSO

	1mg	5mg	10mg	50mg
10 mM	0.4180 mL	2.0901 mL	4.1803 mL	20.9013 mL
20 mM	0.2090 mL	1.0451 mL	2.0901 mL	10.4506 mL
50 mM	0.0836 mL	0.4180 mL	0.8361 mL	4.1803 mL
100 mM	0.0418 mL	0.2090 mL	0.4180 mL	2.0901 mL

Calculator

Molarity Calculator
Dilution Calculator
Reconstitution Calculator
Molecular Weight Calculator

In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:

For example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . TargetMol | Animal experiments

A total of 10 animals were administered, and the formula you used is 5% TargetMol | reagent

DMSO+30% PEG300+5% Tween 80+60% Saline/PBS/ddH₂O. So your working solution concentration is 2 mg/mL。

Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO TargetMol | reagent

(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.

Preparation method for in vivo formula: Take 50 μL DMSO TargetMol | reagent

main solution, add 300 μLPEG300 TargetMol | reagent

mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLSaline/PBS/ddH₂O TargetMol | reagent

mix well and clarify

For Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.

All types of co-solvents required for the protocol, such asDMSO, PEG300/ PEG400, Tween 80, SBE-β-CD, corn oil are available for purchase on the TargetMol website with a simple click.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc