Powder: -20°C for 3 years | In solvent: -80°C for 1 year
Maresin conjugates in tissue regeneration 1 (MCTR1) is a specialized pro-resolving mediator (SPM) synthesized from docosahexaenoic acid in macrophages at the site of inflammation. DHA is oxidized to maresin 1 , which is then converted to MCTR1 by glutathione S-transferase Mu 4 or leukotriene C4 synthase. MCTR1 accelerates tissue regeneration in planaria (1 and 100 nM). Pretreatment with MCTR1 (50 ng/mouse, i.p.) prior to E. coli administration reduces neutrophil infiltration, shortens the inflammatory resolution period, and increases phagocytosis of E. coli by macrophages. When administered at a dose of 100 ng 12h post E. coli infection in a mouse model of peritonitis, MCTR1 reduces the amount of eicosanoids in the exudate.
Pack Size | Availability | Price/USD | Quantity |
---|---|---|---|
10 μg | 35 days | $ 390.00 | |
25 μg | 35 days | $ 923.00 | |
50 μg | 35 days | $ 1,740.00 | |
100 μg | 35 days | $ 2,900.00 |
Description | Maresin conjugates in tissue regeneration 1 (MCTR1) is a specialized pro-resolving mediator (SPM) synthesized from docosahexaenoic acid in macrophages at the site of inflammation. DHA is oxidized to maresin 1 , which is then converted to MCTR1 by glutathione S-transferase Mu 4 or leukotriene C4 synthase. MCTR1 accelerates tissue regeneration in planaria (1 and 100 nM). Pretreatment with MCTR1 (50 ng/mouse, i.p.) prior to E. coli administration reduces neutrophil infiltration, shortens the inflammatory resolution period, and increases phagocytosis of E. coli by macrophages. When administered at a dose of 100 ng 12h post E. coli infection in a mouse model of peritonitis, MCTR1 reduces the amount of eicosanoids in the exudate. |
Synonyms | MCTR1 |
Molecular Weight | 649.8 |
Formula | C32H47N3O9S |
CAS No. | 1784701-61-6 |
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
PBS (pH 7.2): 100 μg/mL
Ethanol: 1 mg/mL
DMF: 50 mg/mL
DMSO: 50 mg/mL
You can also refer to dose conversion for different animals. More
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MCTR1 1784701-61-6 MCTR-1 MCTR 1 inhibitor inhibit