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PI4KIIIbeta-IN-11
(Synonyms: PI4KIIIβ-IN-11) Copy Product Info
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Synonyms: PI4KIIIβ-IN-11
Catalog No. T64106 Copy Product Info
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PI4KIIIbeta-IN-11 is a PI4KIIIβ inhibitor (mean pIC50 = 9.1) that can be used to study diseases caused by RNA viruses and Plasmodium falciparum by blocking PI4KIIIβ, which is involved in intracellular transport and viral replication.
Cas No. 2365241-79-6
| Pack Size | Price | USA Stock | Global Stock | Quantity |
|---|---|---|---|---|
| 25 mg | $1,520 | - | In Stock | |
| 50 mg | $1,980 | - | In Stock | |
| 100 mg | $2,500 | - | In Stock |
For In stock only · Estimated delivery: USA Stock (1-2 days) Global Stock (5-7 days)
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With extensive experience in compound synthesis, we can provide rapid custom synthesis services for this product according to your research needs.
For research use only—not for human use. No sales to individuals. Use as intended only.
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Product Introduction
Bioactivity
Chemical Properties
Storage & Solubility Information
| Description | PI4KIIIbeta-IN-11 is a PI4KIIIβ inhibitor (mean pIC50 = 9.1) that can be used to study diseases caused by RNA viruses and Plasmodium falciparum by blocking PI4KIIIβ, which is involved in intracellular transport and viral replication. |
| Targets & IC50 | PI4KIIIβ:9.1 (pIC50) |
| In vitro | PI4KIIIβ may be a relevant target protein for inhibition of Hedgehog signaling, and regulates trafficking from the Golgi system to the plasma membrane[1]. PI4KIIIbeta-IN-11 (compound 22) (0.5 μM; 0-45 min) shows metabolic stability in human microsomes, with the intrinsic clearance of 33.7 mL/min/g[2]. |
| In vivo | PI4KIIIbeta-IN-11 (compound 22) (1 mg/kg; i.v.; last over 1 h) displays a low spleen concentration in rats[2]. |
| Synonyms | PI4KIIIβ-IN-11 |
| Molecular Weight | 581.71 |
| Formula | C33H39N7O3 |
| Cas No. | 2365241-79-6 |
| Smiles | N(CC1=CC(=CC=C1)C=2N(C)C=CN2)C=3N4C(=C(C(C)=N4)C5=CC(C(N([C@H](CO)C)C)=O)=C(C)C=C5)N=C(C(C)(C)O)C3 |
| Storage | Keep away from direct sunlight,Keep away from moisture,Store at low temperature Powder: -20°C for 3 years | In solvent: -80°C for 1 year Shipping with blue ice/Shipping at ambient temperature. |
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In Vivo Formulation Calculator (Clear solution)
Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:
For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, and a total of 10 animals are to be administered, using a formulation of 
10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH2O , the resulting working solution concentration would be 2 mg/mL.Stock Solution Preparation:
Dissolve 2 mg of the compound in 100 μL DMSO to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.
Preparation of the In Vivo Formulation:
1) Add 100 μL of the DMSO stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.
2) Add 50 μL Tween 80 and mix well until fully clarified.
3) Add 450 μL Saline,PBS or ddH2O and mix thoroughly until a homogeneous solution is obtained.
This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.
Dose Conversion
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Related Tags: PI4KIIIbeta-IN-11 chemical structure | PI4KIIIbeta-IN-11 in vivo | PI4KIIIbeta-IN-11 in vitro | PI4KIIIbeta-IN-11 formula | PI4KIIIbeta-IN-11 molecular weight
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