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Pexidartinib hydrochloride

Name: Pexidartinib hydrochloride
Brand: TargetMol
SKU: T62788
Price: 38 USD
Availability: InStock
Rating: 5 (10 reviews)

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Catalog No. T62788Cas No. 2040295-03-0

Alias PLX-3397 hydrochloride, PLX3397 hydrochloride

Pexidartinib hydrochloride (PLX-3397 HCl) is a selective, orally active, ATP-competitive CSF1R/M-CSFR inhibitor and c-Kit inhibitor with IC50 values of 20 and 10 nM, respectively, capable of inducing cancer cell apoptosis.

Pexidartinib hydrochloride

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Purity: 99.88%

Catalog No. T62788Alias PLX-3397 hydrochloride, PLX3397 hydrochlorideCas No. 2040295-03-0

Pack Size	Price	USA Warehouse	Global Warehouse
5 mg	$38	-	In Stock
10 mg	$53	-	In Stock
25 mg	$87	-	In Stock
50 mg	$123	-	In Stock
100 mg	$156	-	In Stock
500 mg	$372	-	In Stock
1 mL x 10 mM (in DMSO)	$43	-	In Stock

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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]

All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.

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Purity:99.88%

Appearance:Solid

Color:White

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COA HNMR LCMS

Product Introduction

Bioactivity

Description	Pexidartinib hydrochloride (PLX-3397 HCl) is a selective, orally active, ATP-competitive CSF1R/M-CSFR inhibitor and c-Kit inhibitor with IC50 values of 20 and 10 nM, respectively, capable of inducing cancer cell apoptosis.
Targets&IC50	FLT3:160 nM, cFMS:20 nM, KDR:350 nM, LCK:860 nM, FLT1:880 nM, c-Kit:10 nM, NTRK3:890 nM
In vitro	Pexidartinib hydrochloride is a highly potent, selective, ATP-competitive inhibitor of CSF1R (cFMS) and c-Kit. It exhibits 10–100 times greater inhibitory selectivity for c-Kit and CSF1R compared to other related kinases (such as FLT3, KDR (VEGFR2), LCK, FLT1 (VEGFR1), and NTRK3 (TRKC)), with IC50 values of 160 nM, 350 nM, 860 nM, 880 nM, and 890 nM, respectively [1].
In vivo	In the neonatal mouse model, Pexidartinib hydrochloride (0.25 and 1 mg/kg, intraperitoneal injection, twice daily for 8 days) inhibited the proliferation of microglia and BrdU-positive cells [2]. Pexidartinib hydrochloride (1 mg/kg, twice daily for 8 days) did not significantly affect the number of cleaved caspase-3-positive cells in mice [2]. Pexidartinib hydrochloride (50 mg/kg, oral administration, once every two days for 3 weeks) reduced macrophage levels in mouse tissues without interfering with Vitis vinifera glucose homeostasis [4].
Synonyms	PLX-3397 hydrochloride, PLX3397 hydrochloride

Chemical Properties

Molecular Weight	454.28
Formula	C₂₀H₁₆Cl₂F₃N₅
Cas No.	2040295-03-0
Smiles	Cl.FC(F)(F)C1=NC=C(C=C1)CNC2=NC=C(C=C2)CC3=CNC=4N=CC(Cl)=CC43

Storage & Solubility Information

Storage

keep away from direct sunlight | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

H2O: < 1 mg/mL (insoluble)

DMSO: 48 mg/mL (105.66 mM), Sonication is recommended.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	2.2013 mL	11.0064 mL	22.0129 mL	110.0643 mL
5 mM	0.4403 mL	2.2013 mL	4.4026 mL	22.0129 mL
10 mM	0.2201 mL	1.1006 mL	2.2013 mL	11.0064 mL
20 mM	0.1101 mL	0.5503 mL	1.1006 mL	5.5032 mL
50 mM	0.0440 mL	0.2201 mL	0.4403 mL	2.2013 mL
100 mM	0.0220 mL	0.1101 mL	0.2201 mL	1.1006 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:

For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, TargetMol | Animal experiments

and a total of 10 animals are to be administered, using a formulation of TargetMol | reagent

10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH₂O , the resulting working solution concentration would be 2 mg/mL.

Stock Solution Preparation:

Dissolve 2 mg of the compound in 100 μL DMSO TargetMol | reagent to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.

Preparation of the In Vivo Formulation:

1) Add 100 μL of the DMSO TargetMol | reagent stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.

2) Add 50 μL Tween 80 and mix well until fully clarified.

3) Add 450 μL Saline,PBS or ddH₂O TargetMol | reagent and mix thoroughly until a homogeneous solution is obtained.

This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.

All co-solvents required for this protocol, includingDMSO, PEG300/PEG400, Tween 80, SBE-β-CD, and Corn oil, are available for purchase on the TargetMol website.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc