Shopping Cart

Your shopping cart is currently empty

Methazolamide

Name: Methazolamide
Brand: TargetMol
SKU: T0106
Price: 29 USD
Availability: InStock
Rating: 5 (10 reviews)

😃Good

Catalog No. T0106Cas No. 554-57-4

Alias L584601, CL 8490

Methazolamide (CL 8490) is a carbonic anhydrase inhibitor that is used as a diuretic and in the treatment of glaucoma.

Methazolamide

😃Good

Purity: 99.77%

Catalog No. T0106Alias L584601, CL 8490Cas No. 554-57-4

Methazolamide (CL 8490) is a carbonic anhydrase inhibitor that is used as a diuretic and in the treatment of glaucoma.

Pack Size	Price	USA Warehouse	Global Warehouse
200 mg	$31	In Stock	In Stock
500 mg	$48	In Stock	In Stock
1 g	$73	-	In Stock
1 mL x 10 mM (in DMSO)	$29	In Stock	In Stock

Add to Cart

Add to Quotation

In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]

All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.

Questions

Batch Information

Select Batch

Purity:99.77%

Color:White

Resource Download

COA HNMR LCMS

Product Introduction

Bioactivity

Description	Methazolamide (CL 8490) is a carbonic anhydrase inhibitor that is used as a diuretic and in the treatment of glaucoma.
Targets&IC50	CA IV (bovine):36 nM(Ki), CA II (human):14 nM(Ki), CA I (human):50 nM(Ki)
In vitro	Methazolamide is a carbonic anhydrase inhibitor that inhibits hCA I (Ki: 50 nM), hCA II (Ki: 14 nM) and bCA IV (Ki: 36 nM) isoforms.
In vivo	Methazolamide is a carbonic anhydrase inhibitor that inhibits hCA I (Ki: 50 nM), hCA II (Ki: 14 nM) and bCA IV (Ki: 36 nM) isoforms.
Synonyms	L584601, CL 8490

Chemical Properties

Molecular Weight	236.27
Formula	C₅H₈N₄O₃S₂
Cas No.	554-57-4
Smiles	CC(=O)\N=c1\sc(nn1C)S(N)(=O)=O
Relative Density.	1.79g/cm3

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

H2O: < 1 mg/mL (insoluble or slightly soluble)

DMSO: 60 mg/mL (253.95 mM), Sonication is recommended.

Ethanol: 3 mg/mL (12.7 mM), Sonication is recommended.

In Vivo Formulation

10% DMSO+40% PEG300+5% Tween 80+45% Saline: 2 mg/mL (8.46 mM), Sonication is recommended.

Please add the solvents sequentially, clarifying the solution as much as possible before adding the next one. Dissolve by heating and/or sonication if necessary. Working solution is recommended to be prepared and used immediately. The formulation provided above is for reference purposes only. In vivo formulations may vary and should be modified based on specific experimental conditions.

Solution Preparation Table

Ethanol/DMSO

	1mg	5mg	10mg	50mg
1 mM	4.2324 mL	21.1622 mL	42.3245 mL	211.6223 mL
5 mM	0.8465 mL	4.2324 mL	8.4649 mL	42.3245 mL
10 mM	0.4232 mL	2.1162 mL	4.2324 mL	21.1622 mL

DMSO

	1mg	5mg	10mg	50mg
20 mM	0.2116 mL	1.0581 mL	2.1162 mL	10.5811 mL
50 mM	0.0846 mL	0.4232 mL	0.8465 mL	4.2324 mL
100 mM	0.0423 mL	0.2116 mL	0.4232 mL	2.1162 mL

Calculator

Molarity Calculator
Dilution Calculator
Reconstitution Calculator
Molecular Weight Calculator

In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:

For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, TargetMol | Animal experiments

and a total of 10 animals are to be administered, using a formulation of TargetMol | reagent

10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH₂O , the resulting working solution concentration would be 2 mg/mL.

Stock Solution Preparation:

Dissolve 2 mg of the compound in 100 μL DMSO TargetMol | reagent to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.

Preparation of the In Vivo Formulation:

1) Add 100 μL of the DMSO TargetMol | reagent stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.

2) Add 50 μL Tween 80 and mix well until fully clarified.

3) Add 450 μL Saline,PBS or ddH₂O TargetMol | reagent and mix thoroughly until a homogeneous solution is obtained.

This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.

All co-solvents required for this protocol, includingDMSO, PEG300/PEG400, Tween 80, SBE-β-CD, and Corn oil, are available for purchase on the TargetMol website.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc