Contact UsQuotation
Shopping Cart
Remove All
  • TargetMol
    Your shopping cart is currently empty
Proceed to checkoutContinue shopping
TOPBioactivityChemical infoStorage&SolubilityCalculator

Nurr1 inverse agonist-1

🥰Excellent
Catalog No. T78049Cas No. 2758673-07-1

Nurr1 inverse agonist-1 is a indole-based inverse agonist targeting the neuroprotective transcription factor Nurr1, which plays a pivotal role in dopaminergic neuron regulation. Nurr1 inverse agonist-1 decreases the receptor's intrinsic transcriptional activity by up to more than 90% and revealed preference for inhibiting Nurr1 monomer activity. Nurr1 inverse agonist-1 enables the mechanistic study of Nurr1-mediated gene repression and the exploration of its potential implications in neurodegenerative disorders such as Parkinson’s disease.

Nurr1 inverse agonist-1

Nurr1 inverse agonist-1

🥰Excellent
Catalog No. T78049Cas No. 2758673-07-1
Nurr1 inverse agonist-1 is a indole-based inverse agonist targeting the neuroprotective transcription factor Nurr1, which plays a pivotal role in dopaminergic neuron regulation. Nurr1 inverse agonist-1 decreases the receptor's intrinsic transcriptional activity by up to more than 90% and revealed preference for inhibiting Nurr1 monomer activity. Nurr1 inverse agonist-1 enables the mechanistic study of Nurr1-mediated gene repression and the exploration of its potential implications in neurodegenerative disorders such as Parkinson’s disease.
Pack SizePriceUSA WarehouseGlobal WarehouseQuantity
2 mg$142-In Stock
Add to Cart
Add to Quotation
In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]
This molecule is a custom-made product. TargetMol has an excellent synthesis team with the experience and capability to provide you with cost-effective products. However, due to objective factors, there is a small probability that the synthesis may not be successful during the R&D process. We appreciate your understanding. If you have any questions, please feel free to contact us. We are committed to serving you wholeheartedly.
Questions
TargetMol
View More

Batch Information

Select Batch
Contact us for more batch information

Resource Download

COA

Product Introduction

Bioactivity
Description
Nurr1 inverse agonist-1 is a indole-based inverse agonist targeting the neuroprotective transcription factor Nurr1, which plays a pivotal role in dopaminergic neuron regulation. Nurr1 inverse agonist-1 decreases the receptor's intrinsic transcriptional activity by up to more than 90% and revealed preference for inhibiting Nurr1 monomer activity. Nurr1 inverse agonist-1 enables the mechanistic study of Nurr1-mediated gene repression and the exploration of its potential implications in neurodegenerative disorders such as Parkinson’s disease.
Chemical Properties
Molecular Weight266.29
FormulaC16H14N2O2
Cas No.2758673-07-1
SmilesO=C(OC)C1=CN(C2=CC=C(C=C12)C=3C=NC=CC3)C
ColorWhite
AppearanceSolid
Storage & Solubility Information
Storagestore at low temperature | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.
Solubility Information
DMSO: 80 mg/mL (300.42 mM), Sonication is recommended.
Solution Preparation Table
DMSO
1mg5mg10mg50mg
1 mM3.7553 mL18.7765 mL37.5530 mL187.7652 mL
5 mM0.7511 mL3.7553 mL7.5106 mL37.5530 mL
10 mM0.3755 mL1.8777 mL3.7553 mL18.7765 mL
20 mM0.1878 mL0.9388 mL1.8777 mL9.3883 mL
50 mM0.0751 mL0.3755 mL0.7511 mL3.7553 mL
100 mM0.0376 mL0.1878 mL0.3755 mL1.8777 mL

Calculator

  • Molarity Calculator
  • Dilution Calculator
  • Reconstitution Calculator
  • Molecular Weight Calculator

In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:
TargetMol | Animal experimentsFor example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . TargetMol | Animal experiments A total of 10 animals were administered, and the formula you used is 5% TargetMol | reagent DMSO+30% PEG300+5% Tween 80+60% Saline/PBS/ddH2O. So your working solution concentration is 2 mg/mL。
Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSOTargetMol | reagent (mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.
Preparation method for in vivo formula: Take 50 μL DMSOTargetMol | reagent main solution, add 300 μLPEG300TargetMol | reagent mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLSaline/PBS/ddH2OTargetMol | reagent mix well and clarify
For Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.
All types of co-solvents required for the protocol, such asDMSO, PEG300/ PEG400, Tween 80, SBE-β-CD, corn oil are available for purchase on the TargetMol website with a simple click.
1 Enter information below:
mg/kg
g
μL
2 Enter the in vivo formulation:
% DMSO
%
% Tween 80
% Saline/PBS/ddH2O

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc
Related Tags: buy Nurr1 inverse agonist-1 | purchase Nurr1 inverse agonist-1 | Nurr1 inverse agonist-1 cost | order Nurr1 inverse agonist-1 | Nurr1 inverse agonist-1 chemical structure | Nurr1 inverse agonist-1 formula | Nurr1 inverse agonist-1 molecular weight
TargetMol | Logo

Copyright © 2015-2025 TargetMol Chemicals Inc. All Rights Reserved.