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Nurr1 inverse agonist-1

Name: Nurr1 inverse agonist-1
Brand: TargetMol
SKU: T78049
Price: 149 USD
Availability: InStock
Rating: 5 (10 reviews)

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Catalog No. T78049Cas No. 2758673-07-1

Nurr1 inverse agonist-1 is a indole-based inverse agonist targeting the neuroprotective transcription factor Nurr1, which plays a pivotal role in dopaminergic neuron regulation. Nurr1 inverse agonist-1 decreases the receptor's intrinsic transcriptional activity by up to more than 90% and revealed preference for inhibiting Nurr1 monomer activity. Nurr1 inverse agonist-1 enables the mechanistic study of Nurr1-mediated gene repression and the exploration of its potential implications in neurodegenerative disorders such as Parkinson’s disease.

Nurr1 inverse agonist-1

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Catalog No. T78049Cas No. 2758673-07-1

Pack Size	Price	USA Warehouse	Global Warehouse	Quantity
2 mg	$149	-	In Stock

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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]

This molecule is a custom-made product. TargetMol has an excellent synthesis team with the experience and capability to provide you with cost-effective products.If you have any questions, please feel free to contact us. We are committed to serving you wholeheartedly.

All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.

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Batch Information

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Appearance:Solid

Color:White

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COA

Product Introduction

Bioactivity

Description

Chemical Properties

Molecular Weight	266.29
Formula	C₁₆H₁₄N₂O₂
Cas No.	2758673-07-1
Smiles	O=C(OC)C1=CN(C2=CC=C(C=C12)C=3C=NC=CC3)C

Storage & Solubility Information

Storage

store at low temperature | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 80 mg/mL (300.42 mM), Sonication is recommended.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	3.7553 mL	18.7765 mL	37.5530 mL	187.7652 mL
5 mM	0.7511 mL	3.7553 mL	7.5106 mL	37.5530 mL
10 mM	0.3755 mL	1.8777 mL	3.7553 mL	18.7765 mL
20 mM	0.1878 mL	0.9388 mL	1.8777 mL	9.3883 mL
50 mM	0.0751 mL	0.3755 mL	0.7511 mL	3.7553 mL
100 mM	0.0376 mL	0.1878 mL	0.3755 mL	1.8777 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:

For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, TargetMol | Animal experiments

and a total of 10 animals are to be administered, using a formulation of TargetMol | reagent

10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH₂O , the resulting working solution concentration would be 2 mg/mL.

Stock Solution Preparation:

Dissolve 2 mg of the compound in 100 μL DMSO TargetMol | reagent to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.

Preparation of the In Vivo Formulation:

1) Add 100 μL of the DMSO TargetMol | reagent stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.

2) Add 50 μL Tween 80 and mix well until fully clarified.

3) Add 450 μL Saline,PBS or ddH₂O TargetMol | reagent and mix thoroughly until a homogeneous solution is obtained.

This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.

All co-solvents required for this protocol, includingDMSO, PEG300/PEG400, Tween 80, SBE-β-CD, and Corn oil, are available for purchase on the TargetMol website.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc