Shopping Cart

Your shopping cart is currently empty

Pioglitazone

Name: Pioglitazone
Brand: TargetMol
SKU: T0214
Price: 35 USD
Availability: InStock
Rating: 5 (10 reviews)

😃Good

Catalog No. T0214Cas No. 111025-46-8

Alias U 72107

Pioglitazone (U 72107) is a PPARγ agonist with EC50 of 0.93 and 0.99 μM on human and mouse PPARγ, respectively, and has selective and oral activity. Pioglitazone can be used in diabetes research.

Pioglitazone

😃Good

Purity: 99.57%

Catalog No. T0214Alias U 72107Cas No. 111025-46-8

Pioglitazone (U 72107) is a PPARγ agonist with EC50 of 0.93 and 0.99 μM on human and mouse PPARγ, respectively, and has selective and oral activity. Pioglitazone can be used in diabetes research.

Pack Size	Price	USA Warehouse	Global Warehouse
5 mg	$35	In Stock	In Stock
10 mg	$48	In Stock	In Stock
25 mg	$63	In Stock	In Stock
50 mg	$98	In Stock	In Stock
100 mg	$143	In Stock	In Stock
500 mg	$352	-	In Stock
1 mL x 10 mM (in DMSO)	$50	In Stock	In Stock

Add to Cart

Add to Quotation

In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]

All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.

Questions

Batch Information

Select Batch

Purity:99.57%

Resource Download

COA HNMR HPLC

Product Introduction

Bioactivity

Description	Pioglitazone (U 72107) is a PPARγ agonist with EC50 of 0.93 and 0.99 μM on human and mouse PPARγ, respectively, and has selective and oral activity. Pioglitazone can be used in diabetes research.
Targets&IC50	PPARγ (mouse):0.99 μM (EC50), PPARα (human):100 μM (EC50), PPARα (mouse):100 μM (EC50), PPARγ (human):0.93 μM (EC50), PPARδ (human):43 μM (EC50)
In vitro	METHODS: HT-1080, MDA-MB-231, and PC-3 cells were treated with Pioglitazone for 3 days, and target cell toxicity was measured using MTT assay. RESULTS: Pioglitazone did not affect cell growth at 100 μM. [1]
In vivo	METHODS: To investigate the effect of Pioglitazone on insulin resistance, Pioglitazone (10 and 30 mg/kg) was orally administered to ob/ob and adipo-/-ob/ob mice once daily for 14 days. RESULTS: Pioglitazone improves insulin resistance and diabetes, which may be lipocalin-dependent in the liver but not in skeletal muscle. [2] METHODS: To investigate the effect of Pioglitazone on cardiac remodeling, diabetic nephropathy rats were treated with oral administration of Pioglitazone (10 mg/kg) once daily for 4 weeks. RESULTS: Pioglitazone significantly reduced body weight (BW), cardiac hypertrophy, elevated blood glucose levels, and related dyslipidemia. [3]
Synonyms	U 72107

Chemical Properties

Molecular Weight	356.44
Formula	C₁₉H₂₀N₂O₃S
Cas No.	111025-46-8
Smiles	C(C1C(=O)NC(=O)S1)C2=CC=C(OCCC3=CC=C(CC)C=N3)C=C2
Relative Density.	1.26 g/cm3

Storage & Solubility Information

Storage

store under nitrogen | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 28.8 mg/mL (80.8 mM), Heating is recommended.

Ethanol: < 1 mg/mL (insoluble or slightly soluble)

H2O: < 1 mg/mL (insoluble or slightly soluble)

In Vivo Formulation

10% DMSO+90% Corn Oil: 2 mg/mL (5.61 mM), Sonication is recommeded.

Please add the solvents sequentially, clarifying the solution as much as possible before adding the next one. Dissolve by heating and/or sonication if necessary. Working solution is recommended to be prepared and used immediately. The formulation provided above is for reference purposes only. In vivo formulations may vary and should be modified based on specific experimental conditions.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	2.8055 mL	14.0276 mL	28.0552 mL	140.2761 mL
5 mM	0.5611 mL	2.8055 mL	5.6110 mL	28.0552 mL
10 mM	0.2806 mL	1.4028 mL	2.8055 mL	14.0276 mL
20 mM	0.1403 mL	0.7014 mL	1.4028 mL	7.0138 mL
50 mM	0.0561 mL	0.2806 mL	0.5611 mL	2.8055 mL

Calculator

Molarity Calculator
Dilution Calculator
Reconstitution Calculator
Molecular Weight Calculator

In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:

For example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . TargetMol | Animal experiments

A total of 10 animals were administered, and the formula you used is 5% TargetMol | reagent

DMSO+30% PEG300+5% Tween 80+60% Saline/PBS/ddH₂O. So your working solution concentration is 2 mg/mL。

Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO TargetMol | reagent

(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.

Preparation method for in vivo formula: Take 50 μL DMSO TargetMol | reagent

main solution, add 300 μLPEG300 TargetMol | reagent

mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLSaline/PBS/ddH₂O TargetMol | reagent

mix well and clarify

For Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.

All types of co-solvents required for the protocol, such asDMSO, PEG300/ PEG400, Tween 80, SBE-β-CD, corn oil are available for purchase on the TargetMol website with a simple click.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc