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dCeMM1

Catalog No. T67778 CAS 118719-16-7

dCeMM1 is a RBM39 glue degrader. dCeMM1 can re-direct the activity of the CRL4DCAF15 ligase. dCeMM1 can decrease the expression levels of RBM39 in WT KBM7 cells.

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dCeMM1, CAS 118719-16-7

Pack Size	Availability	Price/USD
1 mg	In stock	$ 32.00
5 mg	In stock	$ 74.00
10 mg	In stock	$ 97.00
25 mg	In stock	$ 178.00
50 mg	In stock	$ 297.00
100 mg	In stock	$ 478.00
500 mg	In stock	$ 1,050.00

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Purity: 99.52%

Biological Description

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Storage & Solubility Information

Description	dCeMM1 is a RBM39 glue degrader. dCeMM1 can re-direct the activity of the CRL4DCAF15 ligase. dCeMM1 can decrease the expression levels of RBM39 in WT KBM7 cells.
In vitro	dCeMM1 (0-100 µM; 3 days) inhibited cell growth with the EC50 of 3 and 8 µ M for WT and UBE2Mmut KBM7 cells, respectively. DCeMM1 (10 µ M; 12,16 h) reduced the expression level of RBM39 in WT KBM7 cells [1].

Molecular Weight	369.23
Formula	C14H13BrN2O3S
CAS No.	118719-16-7

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year

Solubility Information

DMSO: 1.8 mg/mL (4.9 mM)

References and Literature

1. Mayor-Ruiz C, et al. Rational discovery of molecular glue degraders via scalable chemical profiling. Nat Chem Biol. 2020 Nov;16(11):1199-1207.

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Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc.

Keywords

dCeMM1 118719-16-7 PROTAC Molecular Glues inhibitor inhibit

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