Anti-CDKN1B Polyclonal Antibody

Name: Anti-CDKN1B Polyclonal Antibody
Brand: TargetMol
SKU: TMAB-00410
Rating: 4.5 (1 reviews)

(Synonyms: p27Kip1, KIP1, Cyclin-Dependent Kinase Inhibitor p27, Cyclin-Dependent Kinase Inhibitor 1B, CDKN1B) Copy Product Info

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Synonyms: p27Kip1, KIP1, Cyclin-Dependent Kinase Inhibitor p27, Cyclin-Dependent Kinase Inhibitor 1B, CDKN1B

Catalog No. TMAB-00410 Copy Product Info

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Anti-CDKN1B Polyclonal Antibody is a Rabbit antibody targeting CDKN1B. Anti-CDKN1B Polyclonal Antibody can be used in FCM,IF,IHC-Fr,WB.

Anti-CDKN1B Polyclonal Antibody

Pack Size	Price	USA Stock	Global Stock
50 μL	$220	7-10 days	7-10 days
100 μL	$372	7-10 days	7-10 days
200 μL	$528	7-10 days	7-10 days

For In stock only · Estimated delivery: USA Stock (1-2 days) Global Stock (5-7 days)

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For research use only—not for human use. No sales to individuals. Use as intended only.

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Instruction Manual of Detection Antibody

Product Introduction

Bioactivity

Description	Anti-CDKN1B Polyclonal Antibody is a Rabbit antibody targeting CDKN1B. Anti-CDKN1B Polyclonal Antibody can be used in FCM,IF,IHC-Fr,WB.
Synonyms	p27Kip1, KIP1, Cyclin-Dependent Kinase Inhibitor p27, Cyclin-Dependent Kinase Inhibitor 1B, CDKN1B
Ig Type	IgG
Reactivity	Human,Mouse,Rat (predicted:Chicken,Dog,Pig,Sheep)

Application	FCM IF IHC-Fr WB
Recommended Dose	WB: 1:500-2000; IHC-Fr: 1:100-500; IF: 1:200-800; FCM: 1μg/Test
Antibody Type	Polyclonal
Host Species	Rabbit
Subcellular Localization	Nucleus. Cytoplasm. Endosome. Note=Nuclear and cytoplasmic in quiescent cells. AKT-or RSK-mediated phosphorylation on Thr-198, binds 14-3-3, translocates to the cytoplasm and promotes cell cycle progression. Mitogen-activated UHMK1 phosphorylation on Ser-10 also results in translocation to the cytoplasm and cell cycle progression. Phosphorylation on Ser-10 facilitates nuclear export. Translocates to the nucleus on phosphorylation of Tyr-88 and Tyr-89. Colocalizes at the endosome with SNX6; this leads to lysosomal degradation.
Tissue Specificity	Expressed in all tissues tested. Highest levels in skeletal muscle, lowest in liver and kidney.
Construction	Polyclonal Antibody
Purification	Protein A purified
Appearance	Liquid
Formulation	0.01M TBS (pH7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol.
Concentration	1 mg/mL
Research Background	Cell cycle progression is regulated by cyclins and their cognate Cdks. p27 KIP 1 is a cell cycle regulatory mitotic inhibitor of cdk activity. p27 KIP 1 is a candidate tumor suppressor gene, and has been proposed to function as a possible mediator of TGF beta induced G1 arrest. p27 KIP 1 is up regulated in response to antimitogenic stimuli. The increased protein expression of p27 results in cellular arrest by binding to cyclin/Cdk complexes such as cyclin D1/Cdk4. p27 Kip1 is regulated by phosphorylation on serine 10 (S10) and threonine 187 (T187). Phosphorylation by CDK2 on T187 results in ubiquitylation and degradation of p27 Kip 1; while phosphorylation by hKIS on S10 signals the nuclear export to the cytoplasm.

Antigen Details

Immunogen	KLH conjugated synthetic peptide: human P27 kip1
Antigen Species	Human
Gene Name	CDKN1B
Gene ID	1027
Protein Name	Cyclin-dependent kinase inhibitor 1B
Uniprot ID	P46527
Biology Area	Cip/Kip,Cip / Kip,Cip/kip
Function	Important regulator of cell cycle progression. Involved in G1 arrest. Potent inhibitor of cyclin E- and cyclin A-CDK2 complexes. Forms a complex with cyclin type D-CDK4 complexes and is involved in the assembly, stability, and modulation of CCND1-CDK4 complex activation. Acts either as an inhibitor or an activator of cyclin type D-CDK4 complexes depending on its phosphorylation state and/or stoichometry.