Powder: -20°C for 3 years | In solvent: -80°C for 1 year
Pabinafusp alfa (JR-141), a transferrin receptor-targeting antibody fusing Iduronate 2-sulfatase with an anti-human transferrin receptor antibody, penetrates the blood-brain barrier and inhibits heparan sulfate (HS) accumulation within the central nervous system of mucopolysaccharidosis II (MPS II) mice. It enhances cognitive function and protects against neuronal damage in the central nervous system [1].
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Description | Pabinafusp alfa (JR-141), a transferrin receptor-targeting antibody fusing Iduronate 2-sulfatase with an anti-human transferrin receptor antibody, penetrates the blood-brain barrier and inhibits heparan sulfate (HS) accumulation within the central nervous system of mucopolysaccharidosis II (MPS II) mice. It enhances cognitive function and protects against neuronal damage in the central nervous system [1]. |
In vivo | Pabinafusp alfa, administered intravenously at doses ranging from 0.1 to 2 mg/kg once weekly for 36 weeks, dose-dependently prevented neuropathological changes and ameliorated neurological deficits in an MPS II murine model [1]. |
Synonyms | JR-141 |
Molecular Weight | N/A |
CAS No. | 2140211-48-7 |
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
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Pabinafusp alfa 2140211-48-7 JR-141 inhibitor inhibit