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Chromenone 1

Name: Chromenone 1
Brand: TargetMol
SKU: T61301
Price: 48 USD
Availability: InStock
Rating: 5 (10 reviews)

🥰Excellent

Catalog No. T61301Cas No. 1639929-29-5

Chromenone 1 is a potent potentiator of osteogenic bone morphogenetic protein (BMP). Chromenone 1 induces a pronounced, kinase-independent, negative TGFβ feedback that enhances nuclear BMP-Smad signaling outputs.

Chromenone 1

🥰Excellent

Purity: 99.93%

Catalog No. T61301Cas No. 1639929-29-5

Pack Size	Price	Availability
1 mg	$48	In Stock
5 mg	$113	In Stock
10 mg	$165	In Stock
25 mg	$248	In Stock
50 mg	$348	In Stock
100 mg	$475	In Stock
200 mg	$639	In Stock
1 mL x 10 mM (in DMSO)	$115	In Stock

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Bulk & Custom

This molecule is a custom-made product. TargetMol has an excellent synthesis team with the experience and capability to provide you with cost-effective products. However, due to objective factors, there is a small probability that the synthesis may not be successful during the R&D process. We appreciate your understanding. If you have any questions, please feel free to contact us. We are committed to serving you wholeheartedly.

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Purity:99.93%

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COA LCMS FNMR HNMR

Product Introduction

Bioactivity

Description	Chromenone 1 is a potent potentiator of osteogenic bone morphogenetic protein (BMP). Chromenone 1 induces a pronounced, kinase-independent, negative TGFβ feedback that enhances nuclear BMP-Smad signaling outputs.
In vitro	Chromenone 1 rescues DMH-1-induced cardiogenesis with an IC50 of 0.2 μM and efficiently stimulates BMP-dependent osteogenesis from C2C12 myoblasts[1].

Chemical Properties

Molecular Weight	357.29
Formula	C₁₈H₁₀F₃N₃O₂
Cas No.	1639929-29-5
Smiles	O=C1C(=C(OC=2C1=CC=CC2)N3C=NC=N3)C4=CC=C(C(F)(F)F)C=C4
Color	Yellow
Appearance	Solid

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 50 mg/mL (139.94 mM), Sonication is recommended.

In Vivo Formulation

10% DMSO+40% PEG300+5% Tween 80+45% Saline: 2 mg/mL (5.6 mM), Sonication is recommended.

Please add the solvents sequentially, clarifying the solution as much as possible before adding the next one. Dissolve by heating and/or sonication if necessary. Working solution is recommended to be prepared and used immediately. The formulation provided above is for reference purposes only. In vivo formulations may vary and should be modified based on specific experimental conditions.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	2.7988 mL	13.9942 mL	27.9885 mL	139.9423 mL
5 mM	0.5598 mL	2.7988 mL	5.5977 mL	27.9885 mL
10 mM	0.2799 mL	1.3994 mL	2.7988 mL	13.9942 mL
20 mM	0.1399 mL	0.6997 mL	1.3994 mL	6.9971 mL
50 mM	0.0560 mL	0.2799 mL	0.5598 mL	2.7988 mL
100 mM	0.0280 mL	0.1399 mL	0.2799 mL	1.3994 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:

For example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . TargetMol | Animal experiments

A total of 10 animals were administered, and the formula you used is 5% TargetMol | reagent

DMSO+30% PEG300+5% Tween 80+60% Saline/PBS/ddH₂O. So your working solution concentration is 2 mg/mL。

Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO TargetMol | reagent

(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.

Preparation method for in vivo formula: Take 50 μL DMSO TargetMol | reagent

main solution, add 300 μLPEG300 TargetMol | reagent

mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLSaline/PBS/ddH₂O TargetMol | reagent

mix well and clarify

For Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.

All types of co-solvents required for the protocol, such asDMSO, PEG300/ PEG400, Tween 80, SBE-β-CD, corn oil are available for purchase on the TargetMol website with a simple click.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Sci Citations

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc