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Mogamulizumab

Catalog No. T76782 CAS 1159266-37-1

Synonyms: KW-0761

Mogamulizumab (KW-0761) is a monoclonal antibody against T cell CC chemokine receptor 4. Mogamulizumab has anticancer activity, eliminating tumor cells through antibody dependent cytotoxicity (ADCC), and can be used to study cancer, adult T-cell leukemia/lymphoma (ATLL), cutaneous T-cell lymphoma (CTCL).

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Mogamulizumab

Mogamulizumab, CAS 1159266-37-1

Pack Size	Availability	Price/USD
1 mg	In stock	$ 476.00
5 mg	In stock	$ 987.00
10 mg	In stock	$ 1,380.00
25 mg	In stock	$ 1,980.00
50 mg	In stock	$ 2,790.00
100 mg	In stock	$ 3,790.00

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Biological Description

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Description	Mogamulizumab (KW-0761) is a monoclonal antibody against T cell CC chemokine receptor 4. Mogamulizumab has anticancer activity, eliminating tumor cells through antibody dependent cytotoxicity (ADCC), and can be used to study cancer, adult T-cell leukemia/lymphoma (ATLL), cutaneous T-cell lymphoma (CTCL).
In vitro	In the presence of PBMCs, Mogamulizumab (10 μg/mL, 24 h) induces ADCC activity against CCR4-positive cell lines (SNT8, SNT16, SNK6, and KAI3)[2]. In PBMCs from patients with HTLV-1–associated myelopathy/tropical spastic paraparesis (HAM/TSP), Mogamulizumab (10 μg/mL, 3 days) reduces the human T-lymphotropic virus type 1 (HTLV-1) proviral load and inhibits spontaneous proliferation[3]. Cultured PBMCs from patients with HAM/TSP treated with Mogamulizumab (1 μg/mL, 5 days) eliminate CD4+CCR4+ T cells[3].
In vivo	In a murine xenograft model, Mogamulizumab (1 mg/kg, i.p., twice per week for 4 weeks) inhibits the growth of EBV-positive NK-cell lymphomas when combined with PBMC transplantation[2]. In a canine bladder cancer-engrafted mouse model, Mogamulizumab (0.1 mg/kg, i.v., every other day) combined with canine PBMCs (administered every fourth day) inhibits tumor growth[4]. Mogamulizumab (0.01-1 mg/kg, i.v.) reduces circulating CD4+CCR4+ T cells in dogs, with no observed adverse effects[4].

Synonyms	KW-0761
Molecular Weight	N/A
CAS No.	1159266-37-1

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References and Literature

1. Duvic M, et al. Mogamulizumab for the treatment of cutaneous T-cell lymphoma: recent advances and clinical potential. Ther Adv Hematol. 2016 Jun;7(3):171-4. 2. Kanazawa T, et al. Anti-CCR4 monoclonal antibody mogamulizumab for the treatment of EBV-associated T- and NK-cell lymphoproliferative diseases. Clin Cancer Res. 2014 Oct 1;20(19):5075-84. 3. Yamauchi J, et al. Mogamulizumab, an anti-CCR4 antibody, targets human T-lymphotropic virus type 1-infected CD8+ and CD4+ T cells to treat associated myelopathy. J Infect Dis. 2015 Jan 15;211(2):238-48. 4. Maeda S, et al. CCR4 Blockade Depletes Regulatory T Cells and Prolongs Survival in a Canine Model of Bladder Cancer. Cancer Immunol Res. 2019 Jul;7(7):1175-1187.

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Keywords

Mogamulizumab 1159266-37-1 Autophagy GPCR/G Protein Immunology/Inflammation CXCR KW-0761 KW 0761 KW0761 inhibitor inhibit

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