T9590 |
T-1095 |
T-1095 is an inhibitor of renal glucose reabsorption and the expression of Na+-glucose cotransporters (SGLTs) and facilitative glucose transporter 2 (GLUT2).
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TN1911 |
Marein |
Marein shows neuroprotective effect on PC12 cell damage induced by methylglyoxal, which is due to a reduction of damage to mitochondria function and activation o...
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T6797 |
CB839 |
CB-839(IC50 of 24 nM), an effective, specific, and oral inhibitor, which is bioavailable glutaminase, for recombinant human GAC.
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T3713 |
BAY876 |
BAY-876 is a potent and selective GLUT1 inhibitor.
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T6791 |
BPTES |
BPTES(IC50 of 0.16 μM) is an effective and specific GlutamiN/Ase GLS1 (KGA) inhibitor.
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T3782 |
Jujuboside A |
Jujuboside A is a glycoside extracted from Semen Ziziphi Spinosae, having neurophysiological inhibitory effects, used as a potential therapeutic agent for the tr...
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T2363 |
STF31 |
STF-31 is an inhibitor of glucose transporter 1 (GLUT1) with IC50 of 1 μM.
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T4138 |
UCPH101 |
UCPH-101 is an inhibitor of excitatory amino acid transporter subtype 1 (EAAT1) with an IC50 of 0.66 μM.
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TN1033 |
Sennidin A |
Sennidin A, has two hydroxyanthraquinone-like moieties, exerts inhibition on NS3 helicase with IC50 values of 0.8 μM.
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TN1034 |
Sennidin B |
Sennidin B stimulates glucose incorporation in rat adipocytes.
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TN1100 |
Nepodin |
Nepodin has antimalarial, and anti-inflammatory activities, it shows significant cyclooxygenase (COX) inhibitory activity. Nepodin has an antidiabetic effect, wh...
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TN1132 |
Procyanidin A2 |
Procyanidin A2 is a potential precursor of 5-(3',4'-dihydroxyphenyl)-γ-valerolactone, exhibits antioxidant, anti-inflammary, anti-hyperglycemia, and anti-type 2...
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TN1681 |
Gentianine |
Gentianine has anti-diabetic, antipsychotic, anti-inflammatory, hypotensive, and diuretic actions, it could be developed as a safe antihypertensive drug.
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TN1740 |
Homoeriodictyol |
Homoeriodictyol, a naturally occurring, bitter-masking flavanone, as a promising agent to increase appetite and food intake. The flavanone homoeriodictyol can in...
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T11055 |
DL-TBOA |
DL-TBOA inhibited [14C] glutamate uptake in COS-1 cells expressing human EAAT1 and EAAT2, with Ki values of 42 μM and 5.7 μM, respectively. DL-TBOA blocks EAAT...
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T9558 |
KL-11743 |
KL-11743 specifically blocks glucose metabolism, triggering an acute collapse in NADH pools and a striking accumulation of aspartate, indicating a dramatic shift...
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T13330 |
WAY-213613 hydrochloride |
WAY-213613 hydrochloride is a selective nonsubstrate reuptake GLT-1/EAAT2 inhibitor (IC50: 85 nM, EAAT2). WAY-213613 hydrochloride displays 59- and 44-fold selec...
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T15728 |
LDN-212320 |
LDN-212320 is a glutamate transporter EAAT2 activator. It also enhances EAAT2 levels by > 6 fold at concentrations < 5 μM after 24 h.
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T13330L |
WAY-213613 |
WAY-213613 is a potent and selective nonsubstrate reuptake inhibitor of GLT-1/EAAT2 (IC50: 85 nM EAAT2). It displays 59- and 44-fold selectivity over EAAT1 and E...
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T8616 |
Fasentin |
Fasentin is an inhibitor of GluT1.
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TN2535 |
1-Hydroxy-2-oxopomolic acid |
1β-Hydroxy-2-oxopomolic acid inhibits adipocyte differentiation through downregulation of various adipocytokines by blocking PPARγ and C/EBPα expression.
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TN3882 |
Dodoviscin A |
Dodoviscin A may be a new promising pigmentation-altering agent for cosmetic and therapeutic applications, it can inhibit melanin biosynthesis induced by 3-isobu...
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TN3883 |
Dodoviscin H |
Dodoviscin H can promote adipocyte differentiation as characterized by increased triglyceride levels in 3T3L1 cells.
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TN3884 |
Dodoviscin I |
Dodoviscin I can promote adipocyte differentiation as characterized by increased triglyceride levels in 3T3L1 cells.
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TN3885 |
Dodoviscin J |
Dodoviscin J can promote adipocyte differentiation as characterized by increased triglyceride levels in 3T3L1 cells.
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TMA0127 |
Ficusin A |
Ficusin has antioxidant, antilipidemic and antidiabetic effects, it can lower the levels of fasting blood glucose, plasma insulin, body weight gain in HFD-STZ in...
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TN4288 |
Isoferulic acid |
Isoferulic acid is an effective natural antioxidant in both lipid and aqueous media, it may be a new promising anti-glycation agent for the prevention of diabeti...
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TN5137 |
Tetramethylkaempferol |
Tetramethylkaempferol is a PPARγ agonist, it can improve insulin sensitivity by increasing the levels of adiponectin, an important adipocytokine associated with...
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T9347 |
F2005-0304 |
F2005-0304 is a thiopyridazine derivative that has been found to increase EAAT2 protein levels in astrocytes.
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T7018 |
WZB117 |
WZB117 is a Glucose Transporter 1 (GLUT1) inhibitor. when IC50 of WZB117 approximate 10 μM, it inhibits lung cancer A549 cells and breast cancer MCF7 cells prol...
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