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JNJ-49095397

Name: JNJ-49095397
Brand: TargetMol
SKU: T72918
Price: 88 USD
Availability: InStock
Rating: 5 (10 reviews)

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Catalog No. T72918Cas No. 1220626-82-3

Alias RV568

JNJ-49095397 (RV568) is a selective p38 MAPK-α and p38 MAPK--γ kinase inhibitor with anti-inflammatory activity and potential antiviral activity for chronic obstructive pulmonary disease (COPD), cystic fibrosis, and respiratory syncytial virus infection.

JNJ-49095397

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Purity: 99.04%

Catalog No. T72918Alias RV568Cas No. 1220626-82-3

Pack Size	Price	USA Warehouse	Global Warehouse
1 mg	$88	In Stock	In Stock
5 mg	$213	In Stock	In Stock
10 mg	$347	In Stock	In Stock
25 mg	$695	In Stock	In Stock
50 mg	$1,090	In Stock	In Stock

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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]

This molecule is a custom-made product. TargetMol has an excellent synthesis team with the experience and capability to provide you with cost-effective products.If you have any questions, please feel free to contact us. We are committed to serving you wholeheartedly.

All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.

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Purity:99.04%

Appearance:Solid

Color:White

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COA HNMR LCMS

Product Introduction

Bioactivity

Description	JNJ-49095397 (RV568) is a selective p38 MAPK-α and p38 MAPK--γ kinase inhibitor with anti-inflammatory activity and potential antiviral activity for chronic obstructive pulmonary disease (COPD), cystic fibrosis, and respiratory syncytial virus infection.
In vitro	JNJ-49095397 (1 μg-1 g/mL; 4 h) demonstrates potent anti-inflammatory effects in monocytes and macrophages. When used in combination with corticosteroids, it exhibits synergistic anti-inflammatory effects in poly I:C-stimulated BEAS-2B cells and cigarette smoke models[1].
In vivo	In non-fasted Balb/c mice, in the LPS-induced neutrophil accumulation model, JNJ-49095397 (1, 4, and 20 μg/mouse; intratracheal administration, 2, 8, or 12 h prior to LPS inhalation) prevented the accumulation of neutrophils in the BAL fluid. Significant inhibition of neutrophil accumulation was observed when administered up to 8 h prior to LPS inhalation[1].
Synonyms	RV568

Chemical Properties

Molecular Weight	592.69
Formula	C₃₄H₃₆N₆O₄
Cas No.	1220626-82-3
Smiles	O=C(NC1=CC=C(OCC=2C=CN=C(C2)NC(=O)COC)C=3C=CC=CC13)NC4=CC(=NN4C5=CC=C(C=C5)C)C(C)(C)C

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 80 mg/mL (134.98 mM), Sonication is recommended.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	1.6872 mL	8.4361 mL	16.8722 mL	84.3611 mL
5 mM	0.3374 mL	1.6872 mL	3.3744 mL	16.8722 mL
10 mM	0.1687 mL	0.8436 mL	1.6872 mL	8.4361 mL
20 mM	0.0844 mL	0.4218 mL	0.8436 mL	4.2181 mL
50 mM	0.0337 mL	0.1687 mL	0.3374 mL	1.6872 mL
100 mM	0.0169 mL	0.0844 mL	0.1687 mL	0.8436 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:

For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, TargetMol | Animal experiments

and a total of 10 animals are to be administered, using a formulation of TargetMol | reagent

10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH₂O , the resulting working solution concentration would be 2 mg/mL.

Stock Solution Preparation:

Dissolve 2 mg of the compound in 100 μL DMSO TargetMol | reagent to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.

Preparation of the In Vivo Formulation:

1) Add 100 μL of the DMSO TargetMol | reagent stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.

2) Add 50 μL Tween 80 and mix well until fully clarified.

3) Add 450 μL Saline,PBS or ddH₂O TargetMol | reagent and mix thoroughly until a homogeneous solution is obtained.

This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.

All co-solvents required for this protocol, includingDMSO, PEG300/PEG400, Tween 80, SBE-β-CD, and Corn oil, are available for purchase on the TargetMol website.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc